User talk:Toddjfield/sandbox

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ToddjField: Stellate cells are GABAergic inhibitory interneurons that are found in the molecular layer of the cerebellum. Any neuron that has a star like shape formed by dendritic processes is classified as a stellate cell. Stellate cells are derived from dividing progenitors in the white matter of postnatal cerebellum. Dendritic trees can vary between neurons. There are two types of dendritic trees in the cerebral cortex. Pyramidal cells, which are pyramid shaped and stellate cells which are star shaped. Cells dendrites can also help is the neuron classification. Dendrites with spines are classified as spiny, those without spines are classified as aspinous. Stellate cells can be spiny or aspinous, while pyramidal cells are always spiny. The three most common stellate cells are inhibitory interneurons, excitatory spiny stellate cells, and inhibitory aspinous stellate inter neurons.

@Glofland:

Todd, can we use your sandbox as the group's sandbox? Damid001 (talk) 15:58, 9 November 2018 (UTC)Dalton[reply]

There are suggestions on the talk page of the Stellate Cells to start linking to other, more specific stellate cell articles such as cortical spiny, cerebellar, and [cortical] aspinous. I have some issues with that given that we'd have to make new pages for many of these and I don't have much information for more specific pages, also I don't know all of the different kinds and places, but we could make a list and publish that? Damid001 (talk) 15:40, 16 November 2018 (UTC)Dalton[reply]


Wren's Peer Review[edit]

I think this is a great start, there is a lot of information here that helps to make the page more comprehensive.

One suggestion that I have is to include more hyperlinks, this allows you to be more concise while also providing the reader with places to find more information. One specific place I think this could be helpful is when defining what stellate cells and pyramidal cells are, maybe hyperlink a source to each the further explains. I think another thing that could be helpful in this instance is to include a schematic or a drawing to help illustrate what the cells look like and the differences in dendritic patterns.

I also think that you might be able to split up the main section under "Satelite Cells" on the page. There is a great background there but toward the end of the paragraph, it talks about firing patterns and how stellate cells are chromophobes. I think that this information, especially the part about firing patterns, could almost be its own section or at least in a new paragraph.

The development section is very informative. The only question I had was about the sentence starting with "After mitosis, these cells..." Which cells are you talking about? Make sure you are specific.

There was a good use of unbias information and data/facts drawn from different sources. I think this will be a great page when it is finished!

Elwak001 (talk)elwak001 —Preceding undated comment added 02:42, 13 November 2018 (UTC)[reply]

Esai's Peer Review[edit]

I think your off to a good start. Reading the article I had the same suggestion as Wren when it came to linking the pages for pyramidal cells. It just makes it so much more easier for people to understand the topic because they can simply click it and read up on it if they have confusion.

Maybe you can make various subsections on the most common stellate cells: inhibitory interneurons, excitatory spiny stellate cells, and inhibitory aspinous stellate inter neurons. Perhaps look into their functions and relationships between each other. I think it benefit the article and give you more to add to the article as well.

Keep up the good work. Esher001 (talk) 17:19, 14 November 2018 (UTC)Esai Hernandez[reply]

Article Draft To Work With[edit]

This page is about Stellate cells in the central nervous system. For other uses, see Stellate cell.
Stellate cell
Golgi stained cortical neurons A) Layer II/IIIpyramidal cell B) layer IV spiny stellate cell
Microcircuitry of the cerebellum. Excitatory synapses are denoted by (+) and inhibitory synapses by (-).
MF: Mossy fiber.
DCN: Deep cerebellar nuclei.
IO: Inferior olive.
CF: Climbing fiber.
GC: Granule cell.
PF: Parallel fiber.
PC: Purkinje cell.
GgC: Golgi cell.
SC: Stellate cell.
BC: Basket cell.
Anatomical terms of neuroanatomy

Stellate cells are any neuron in the central nervous system that have a star-like shape formed by dendritic processes radiating from the cell body. Many Stellate cells are GABAergic and are located in the molecular layer of the cerebellum.[1] Stellate cells are derived from dividing progenitors in the white matter of postnatal cerebellum. Dendritic trees can vary between neurons. There are two types of dendritic trees in the cerebral cortex, which include pyramidal cells, which are pyramid shaped and stellate cells which are star shaped. Dendrites can also aid neuron classification. Dendrites with spines are classified as spiny, those without spines are classified as aspinous.[2] Stellate cells can be spiny or aspinous, while pyramidal cells are always spiny. Most common stellate cells are the inhibitory interneurons found within the upper half of the molecular layer in the cerebellum.[3] Cerebellar stellate cells synapse onto the dendritic arbors of Purkinje cells and send inhibitory signals.[4] Stellate neurons are sometimes found in other locations in the central nervous system; cortical spiny stellate cells are found in layer IVC of the V1 region in the visual cortex.[2] In the somatosensory barrel cortex of mice and rats, glutamatergic (excitatory) spiny stellate cells are organized in the barrels of layer 4.[5] They receive excitatory synaptic fibres from the thalamus and process feed forward excitation to 2/3 layer of V1 visual cortex to pyramidal cells. Cortical spiny stellate cells have a 'regular' firing pattern. Stellate cells are chromophobes, that is cells that does not stain readily, and thus appears relatively pale under the microscope.


Cerebellar Stellate Cells are inhibitory and GABAergic[6]. Stellate and basket cells originate from the cerebellar ventricular zone (CVZ) along with Purkinje cells and Bergmann glia[7][8] Due to their similarity, basket and stellate cells are grouped together when examined during migration, especially given they follow the same pathway. After mitosis, these cells start in the deep layer of the white matter and migrate up through the internal granular layer (IGL) and purkinje cell layer (PCL)[9] until they reach the molecular layer. During their time in the molecular layer, they change orientation and positioning until they eventually end up in the middle portion of this layer, facing the rostrocaudal direction.[10] Once in this layer, the stellate cells are guided to their correct placement by Bergman glial cells.[11]

Aspinous stellate cells are GABAergic cells are found in somatosensory cortex. Apart from visual classification of the aspinous dendrites, they can be immunohistochemically labelled with glutamic acid decarboxylase(GAD) because of their GABAergic activity, and occasionally colocalize with neuropeptides[12].

Damid001 (talk) 16:15, 30 November 2018 (UTC)Dalton[reply]

Stellate Ganglion[edit]

See Stellate ganglion — Preceding unsigned comment added by Damid001 (talk • contribs) 02:08, 7 December 2018 (UTC)[reply]

References[edit]

  1. ^ Patterning and Cell Type Specification in the Developing CNS and PNS : Comprehensive Developmental Neuroscience. Elsevier Science. 2013. p. 215. ISBN 978-0-12-397265-1.
  2. ^ a b Costa, Nuno Maçarico da; Martin, Kevan A. C. (2011-02-23). "How Thalamus Connects to Spiny Stellate Cells in the Cat's Visual Cortex". Journal of Neuroscience. 31 (8): 2925–2937. doi:10.1523/JNEUROSCI.5961-10.2011. ISSN 0270-6474. PMID 21414914.
  3. ^ Patterning and Cell Type Specification in the Developing CNS and PNS : Comprehensive Developmental Neuroscience (1 ed.). Elsevier Science. 2013. ISBN 978-0-12-397265-1.
  4. ^ Chan-Palay, Victoria; Palay, Sanford L. (1972-01-01). "The stellate cells of the rat's cerebellar cortex". Zeitschrift für Anatomie und Entwicklungsgeschichte. 136 (2): 224–248. doi:10.1007/BF00519180. ISSN 0044-2232.
  5. ^ Petersen, Carl C.H. (October 2007). "The Functional Organization of the Barrel Cortex". Neuron. 56 (2): 339–355. doi:10.1016/j.neuron.2007.09.017. ISSN 0896-6273.
  6. ^ Rubenstein, John; Rakic, Pasko; Rubenstein, John (2013-05-06). Patterning and cell type specification in the developing CNS and PNS : comprehensive developmental neuroscience (1st ed.). Academic Press. ISBN 9780123973481.
  7. ^ Comprehensive developmental neuroscience. Cellular migration and formation of neuronal connections (First ed.). Elsevier Science & Technology. 2013. p. 283. ISBN 978-0-12-397266-8.
  8. ^ "Cerebellar Ventricular Zone - Cellular Development, Function & Anatomy - LifeMap Discovery". discovery.lifemapsc.com. LifeMap Sciences.
  9. ^ Comprehensive developmental neuroscience. Cellular migration and formation of neuronal connections (First ed.). Elsevier Science and Technology. 2013. p. 284. ISBN 978-0-12-397266-8.
  10. ^ Rubenstein, John (2013-05-06). Patterning and Cell Type Specification in the Developing CNS and PNS : Comprehensive Developmental Neuroscience. Elsevier Science & Technology. ISBN 9780123973481.
  11. ^ Rubenstein, John (2013-05-06). Neural Circuit Development and Function in the Brain : Comprehensive Developmental Neuroscience. Elsevier Science & Technology. ISBN 9780123973467.
  12. ^ Conn, P. Michael (2008). Neuroscience in medicine (3rd ed.). Beaverton, OR: Humana Press. ISBN 9781603274548.

https://ebookcentral.proquest.com/lib/goucher-ebooks/reader.action?docID=372379&query=stellate+neurons


Glofland (talk) 16:22, 16 November 2018 (UTC)glofland[reply]

External links[edit]

Category:Cerebellum Category:Human cells

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