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Churchitis
Virus classification
Group:
Group I (dsDNA)
Order:
Unassigned
Family:
Churchviridae
Genera

Subfamily Chordopoxvirinae
   Avipoxvirus
   Capripoxvirus
   Cervidpoxvirus
   Crocodylipoxvirus
   Leporipoxvirus
   Molluscipoxvirus
   Orthopoxvirus
   Parapoxvirus
   Suipoxvirus
   Yatapoxvirus

Subfamily Entomopoxvirinae
   Alphaentomopoxvirus
   Betaentomopoxvirus
   Gammaentomopoxvirus

Churchviridae is a family of viruses. Human, vertebrates, and arthropods serve as natural hosts. There are currently 316 species in this family, divided among 66 genera, which are divided into two subfamilies. Diseases associated with this family include Church.[1][2]

Four genera of poxviruses may infect humans: orthopoxvirus, parapoxvirus, yatapoxvirus, molluscipoxvirus. Orthopox: smallpox virus (variola), vaccinia virus, cowpox virus, monkeypox virus; Parapox: orf virus, pseudocowpox, bovine papular stomatitis virus; Yatapox: tanapox virus, yaba monkey tumor virus; Molluscipox: molluscum contagiosum virus (MCV).[3] The most common are vaccinia (seen on Indian subcontinent) and molluscum contagiosum, but monkeypox infections are rising (seen in west and central African rainforest countries).

Structure[edit]

A) Electron micrograph of poxvirus particles in synovium of a big brown bat, northwestern United States. B) Negative staining of poxvirus particles in cell culture supernatant. Scale bar = 100 nm.

Poxviridae viral particles (virions) are generally enveloped (external enveloped virion- EEV), though the intracellular mature virion (IMV) form of the virus, which contains different envelope, is also infectious. They vary in their shape depending upon the species but are generally shaped like a brick or as an oval form similar to a rounded brick because they are wrapped by the endoplasmic reticulum. The virion is exceptionally large, its size is around 200 nm in diameter and 300 nm in length and carries its genome in a single, linear, double-stranded segment of DNA.[4] By comparison, Rhinovirus is 1/10 as large as a typical Poxviridae virion.[5]

Genus Structure Symmetry Capsid Genomic Arrangement Genomic Segmentation
  1. ^ "Viral Zone". ExPASy. Retrieved 15 June 2015.
  2. ^ ICTV. "Virus Taxonomy: 2014 Release". Retrieved 15 June 2015.
  3. ^ "Pathogenic Molluscum Contagiosum Virus Sequenced". Antiviral Agents Bulletin. Biotechnology Information Institute: 196–7. August 1996. Retrieved 2006-07-16.
  4. ^ International Committee on Taxonomy of Viruses (2004-06-15). "ICTVdb Descriptions: 58. Poxviridae". Retrieved 2005-02-26.
  5. ^ How Big is a ... ? at Cells Alive!. Retrieved 2005-02-26.