Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 09:34, 7 November 2007 (UTC)[edit]
Proteins without matches (18)[edit]
Proteins with a High Potential Match (7)[edit]
Created (7)[edit]
Manual Inspection (Page not found) (18)[edit]
Protein Status Grid - Date: 09:34, 7 November 2007 (UTC)[edit]
Vebose Log - Date: 09:34, 7 November 2007 (UTC)[edit]
- INFO: Beginning work on ALDH2... {November 7, 2007 1:09:34 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ALDH2 image.jpg {November 7, 2007 1:10:05 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:10:21 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ALDH2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a4z.
| PDB = {{PDB2|1a4z}}, {{PDB2|1ag8}}, {{PDB2|1cw3}}, {{PDB2|1nzw}}, {{PDB2|1nzx}}, {{PDB2|1nzz}}, {{PDB2|1o00}}, {{PDB2|1o01}}, {{PDB2|1o02}}, {{PDB2|1o04}}, {{PDB2|1o05}}, {{PDB2|1of7}}, {{PDB2|1zum}}, {{PDB2|2onm}}, {{PDB2|2onn}}, {{PDB2|2ono}}, {{PDB2|2onp}}
| Name = Aldehyde dehydrogenase 2 family (mitochondrial)
| HGNCid = 404
| Symbol = ALDH2
| AltSymbols =; ALDH-E2; ALDHI; ALDM; MGC1806
| OMIM = 100650
| ECnumber =
| Homologene = 55480
| MGIid = 99600
| GeneAtlas_image1 = PBB_GE_ALDH2_201425_at_tn.png
| Function = {{GNF_GO|id=GO:0004029 |text = aldehyde dehydrogenase (NAD) activity}} {{GNF_GO|id=GO:0004030 |text = aldehyde dehydrogenase [NAD(P)+] activity}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006066 |text = alcohol metabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 217
| Hs_Ensembl = ENSG00000111275
| Hs_RefseqProtein = NP_000681
| Hs_RefseqmRNA = NM_000690
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 110688729
| Hs_GenLoc_end = 110732165
| Hs_Uniprot = P05091
| Mm_EntrezGene = 11669
| Mm_Ensembl = ENSMUSG00000029455
| Mm_RefseqmRNA = NM_009656
| Mm_RefseqProtein = NP_033786
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 121828319
| Mm_GenLoc_end = 121854203
| Mm_Uniprot = Q3TVM2
}}
}}
'''Aldehyde dehydrogenase 2 family (mitochondrial)''', also known as '''ALDH2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.<ref>{{cite web | title = Entrez Gene: ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=217| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Yoshida A |title=Molecular genetics of human aldehyde dehydrogenase. |journal=Pharmacogenetics |volume=2 |issue= 4 |pages= 139-47 |year= 1993 |pmid= 1306115 |doi= }}
*{{cite journal | author=Chao YC, Liou SR, Tsai SF, Yin SJ |title=Dominance of the mutant ALDH2(2) allele in the expression of human stomach aldehyde dehydrogenase-2 activity. |journal=Proc. Natl. Sci. Counc. Repub. China B |volume=17 |issue= 3 |pages= 98-102 |year= 1994 |pmid= 8290656 |doi= }}
*{{cite journal | author=Seitz HK, Meier P |title=The role of acetaldehyde in upper digestive tract cancer in alcoholics. |journal=Translational research : the journal of laboratory and clinical medicine |volume=149 |issue= 6 |pages= 293-7 |year= 2007 |pmid= 17543846 |doi= 10.1016/j.trsl.2006.12.002 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on APAF1... {November 7, 2007 1:10:21 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein APAF1 image.jpg {November 7, 2007 1:11:29 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:11:41 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_APAF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1c15.
| PDB = {{PDB2|1c15}}, {{PDB2|1cww}}, {{PDB2|1cy5}}, {{PDB2|1z6t}}, {{PDB2|2p1h}}, {{PDB2|2ygs}}, {{PDB2|3ygs}}
| Name = Apoptotic peptidase activating factor 1
| HGNCid = 576
| Symbol = APAF1
| AltSymbols =; CED4
| OMIM = 602233
| ECnumber =
| Homologene = 7626
| MGIid = 1306796
| GeneAtlas_image1 = PBB_GE_APAF1_204859_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_APAF1_211553_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_APAF1_211554_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008656 |text = caspase activator activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0001843 |text = neural tube closure}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0008635 |text = caspase activation via cytochrome c}} {{GNF_GO|id=GO:0030900 |text = forebrain development}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 317
| Hs_Ensembl = ENSG00000120868
| Hs_RefseqProtein = NP_001151
| Hs_RefseqmRNA = NM_001160
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 97563209
| Hs_GenLoc_end = 97653335
| Hs_Uniprot = O14727
| Mm_EntrezGene = 11783
| Mm_Ensembl = ENSMUSG00000019979
| Mm_RefseqmRNA = NM_001042558
| Mm_RefseqProtein = NP_001036023
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 90419117
| Mm_GenLoc_end = 90512538
| Mm_Uniprot = Q4VZG8
}}
}}
'''Apoptotic peptidase activating factor 1''', also known as '''APAF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.<ref>{{cite web | title = Entrez Gene: APAF1 apoptotic peptidase activating factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=317| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Smith TF, Gaitatzes C, Saxena K, Neer EJ |title=The WD repeat: a common architecture for diverse functions. |journal=Trends Biochem. Sci. |volume=24 |issue= 5 |pages= 181-5 |year= 1999 |pmid= 10322433 |doi= }}
*{{cite journal | author=van Oirschot JT |title=Diva vaccines that reduce virus transmission. |journal=J. Biotechnol. |volume=73 |issue= 2-3 |pages= 195-205 |year= 1999 |pmid= 10486928 |doi= }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
*{{cite journal | author=Campioni M, Santini D, Tonini G, ''et al.'' |title=Role of Apaf-1, a key regulator of apoptosis, in melanoma progression and chemoresistance. |journal=Exp. Dermatol. |volume=14 |issue= 11 |pages= 811-8 |year= 2006 |pmid= 16232302 |doi= 10.1111/j.1600-0625.2005.00360.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on APOA5... {November 7, 2007 1:31:28 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:31:51 AM PST}
- CREATED: Created new protein page: APOA5 {November 7, 2007 1:31:58 AM PST}
- INFO: Beginning work on ATF2... {November 7, 2007 1:18:30 AM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:19:21 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:19:39 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ATF2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bhi.
| PDB = {{PDB2|1bhi}}, {{PDB2|1t2k}}
| Name = Activating transcription factor 2
| HGNCid = 784
| Symbol = ATF2
| AltSymbols =; CREB2; CRE-BP1; HB16; MGC111558; TREB7
| OMIM = 123811
| ECnumber =
| Homologene = 31061
| MGIid = 109349
| GeneAtlas_image1 = PBB_GE_ATF2_205446_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ATF2_212984_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1386
| Hs_Ensembl = ENSG00000115966
| Hs_RefseqProtein = NP_001871
| Hs_RefseqmRNA = NM_001880
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 175645228
| Hs_GenLoc_end = 175741161
| Hs_Uniprot = P15336
| Mm_EntrezGene = 11909
| Mm_Ensembl = ENSMUSG00000027104
| Mm_RefseqmRNA = NM_001025093
| Mm_RefseqProtein = NP_001020264
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 73617360
| Mm_GenLoc_end = 73664083
| Mm_Uniprot = P70299
}}
}}
'''Activating transcription factor 2''', also known as '''ATF2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined.<ref>{{cite web | title = Entrez Gene: ATF2 activating transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1386| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AVP... {November 7, 2007 1:11:41 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein AVP image.jpg {November 7, 2007 1:12:10 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:12:29 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_AVP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jk4.
| PDB = {{PDB2|1jk4}}, {{PDB2|1jk6}}, {{PDB2|1npo}}, {{PDB2|2bn2}}
| Name = Arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal)
| HGNCid = 894
| Symbol = AVP
| AltSymbols =; ADH; ARVP; AVP-NPII; AVRP; VP
| OMIM = 192340
| ECnumber =
| Homologene = 417
| MGIid = 88121
| GeneAtlas_image1 = PBB_GE_AVP_207848_at_tn.png
| Function = {{GNF_GO|id=GO:0005185 |text = neurohypophyseal hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0006833 |text = water transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0030146 |text = diuresis}} {{GNF_GO|id=GO:0030819 |text = positive regulation of cAMP biosynthetic process}} {{GNF_GO|id=GO:0042310 |text = vasoconstriction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 551
| Hs_Ensembl = ENSG00000101200
| Hs_RefseqProtein = NP_000481
| Hs_RefseqmRNA = NM_000490
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 3011203
| Hs_GenLoc_end = 3014058
| Hs_Uniprot = P01185
| Mm_EntrezGene = 11998
| Mm_Ensembl = ENSMUSG00000037727
| Mm_RefseqmRNA = NM_009732
| Mm_RefseqProtein = NP_033862
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 130272062
| Mm_GenLoc_end = 130273995
| Mm_Uniprot = Q3UUQ5
}}
}}
'''Arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal)''', also known as '''AVP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin II and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin II, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI).<ref>{{cite web | title = Entrez Gene: AVP arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=551| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Riphagen CL, Pittman QJ |title=Arginine vasopressin as a central neurotransmitter. |journal=Fed. Proc. |volume=45 |issue= 9 |pages= 2318-22 |year= 1986 |pmid= 2874053 |doi= }}
*{{cite journal | author=Ishikawa SE |title=[Nephrogenic diabetes insipidus associated with mutations of vasopressin V2 receptors and aquaporin-2] |journal=Nippon Rinsho |volume=60 |issue= 2 |pages= 350-5 |year= 2002 |pmid= 11857925 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCND3... {November 7, 2007 1:14:10 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:14:39 AM PST}
- CREATED: Created new protein page: CCND3 {November 7, 2007 1:14:45 AM PST}
- INFO: Beginning work on CCR3... {November 7, 2007 1:15:48 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:16:27 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chemokine (C-C motif) receptor 3
| HGNCid = 1604
| Symbol = CCR3
| AltSymbols =; CC-CKR-3; CD193; CKR3; CMKBR3; MGC102841
| OMIM = 601268
| ECnumber =
| Homologene = 20436
| MGIid = 104616
| GeneAtlas_image1 = PBB_GE_CCR3_208304_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016493 |text = C-C chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007188 |text = G-protein signaling, coupled to cAMP nucleotide second messenger}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1232
| Hs_Ensembl = ENSG00000183625
| Hs_RefseqProtein = NP_001828
| Hs_RefseqmRNA = NM_001837
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 46227186
| Hs_GenLoc_end = 46283103
| Hs_Uniprot = P51677
| Mm_EntrezGene = 12771
| Mm_Ensembl = ENSMUSG00000035448
| Mm_RefseqmRNA = NM_009914
| Mm_RefseqProtein = NP_034044
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 123870898
| Mm_GenLoc_end = 123879738
| Mm_Uniprot = Q3U5L7
}}
}}
'''Chemokine (C-C motif) receptor 3''', also known as '''CCR3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.<ref>{{cite web | title = Entrez Gene: CCR3 chemokine (C-C motif) receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1232| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Marone G, Florio G, Petraroli A, de Paulis A |title=Dysregulation of the IgE/Fc epsilon RI network in HIV-1 infection. |journal=J. Allergy Clin. Immunol. |volume=107 |issue= 1 |pages= 22-30 |year= 2001 |pmid= 11149986 |doi= }}
*{{cite journal | author=Marone G, Florio G, Triggiani M, ''et al.'' |title=Mechanisms of IgE elevation in HIV-1 infection. |journal=Crit. Rev. Immunol. |volume=20 |issue= 6 |pages= 477-96 |year= 2001 |pmid= 11396683 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CDK7... {November 7, 2007 1:14:45 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CDK7 image.jpg {November 7, 2007 1:15:25 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:15:41 AM PST}
- CREATED: Created new protein page: CDK7 {November 7, 2007 1:15:48 AM PST}
- INFO: Beginning work on CEACAM1... {November 7, 2007 1:12:29 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CEACAM1 image.jpg {November 7, 2007 1:13:56 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:14:10 AM PST}
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{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CEACAM1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2gk2.
| PDB = {{PDB2|2gk2}}
| Name = Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
| HGNCid = 1814
| Symbol = CEACAM1
| AltSymbols =; BGP; BGP1; BGPI
| OMIM = 109770
| ECnumber =
| Homologene = 86044
| MGIid = 1347245
| GeneAtlas_image1 = PBB_GE_CEACAM1_206576_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CEACAM1_209498_at_tn.png
| GeneAtlas_image3 = PBB_GE_CEACAM1_211883_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0016477 |text = cell migration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 634
| Hs_Ensembl = ENSG00000079385
| Hs_RefseqProtein = NP_001020083
| Hs_RefseqmRNA = NM_001024912
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 47703298
| Hs_GenLoc_end = 47724479
| Hs_Uniprot = P13688
| Mm_EntrezGene = 26365
| Mm_Ensembl = ENSMUSG00000074272
| Mm_RefseqmRNA = XM_989614
| Mm_RefseqProtein = XP_994708
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 24990200
| Mm_GenLoc_end = 25186385
| Mm_Uniprot = Q3LFS7
}}
}}
'''Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)''', also known as '''CEACAM1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.<ref>{{cite web | title = Entrez Gene: CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=634| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gray-Owen SD, Blumberg RS |title=CEACAM1: contact-dependent control of immunity. |journal=Nat. Rev. Immunol. |volume=6 |issue= 6 |pages= 433-46 |year= 2006 |pmid= 16724098 |doi= 10.1038/nri1864 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CNR1... {November 7, 2007 1:16:27 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:17:44 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cannabinoid receptor 1 (brain)
| HGNCid = 2159
| Symbol = CNR1
| AltSymbols =; CANN6; CB-R; CB1; CB1A; CB1K5; CNR
| OMIM = 114610
| ECnumber =
| Homologene = 7273
| MGIid = 104615
| GeneAtlas_image1 = PBB_GE_CNR1_208243_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CNR1_213436_at_tn.png
| GeneAtlas_image3 = PBB_GE_CNR1_207940_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004949 |text = cannabinoid receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007610 |text = behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1268
| Hs_Ensembl = ENSG00000118432
| Hs_RefseqProtein = NP_057167
| Hs_RefseqmRNA = NM_016083
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 88906302
| Hs_GenLoc_end = 88932385
| Hs_Uniprot = P21554
| Mm_EntrezGene = 12801
| Mm_Ensembl = ENSMUSG00000044288
| Mm_RefseqmRNA = NM_007726
| Mm_RefseqProtein = NP_031752
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 34253206
| Mm_GenLoc_end = 34277444
| Mm_Uniprot = Q99NU3
}}
}}
'''Cannabinoid receptor 1 (brain)''', also known as '''CNR1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that is one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the family of guanine-nucleotide-binding protein (G-protein) coupled receptors which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Two transcript variants encoding different isoforms have been described for this gene.<ref>{{cite web | title = Entrez Gene: CNR1 cannabinoid receptor 1 (brain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1268| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Oddi S, Spagnuolo P, Bari M, ''et al.'' |title=Differential modulation of type 1 and type 2 cannabinoid receptors along the neuroimmune axis. |journal=Int. Rev. Neurobiol. |volume=82 |issue= |pages= 327-37 |year= 2007 |pmid= 17678969 |doi= 10.1016/S0074-7742(07)82017-4 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CP... {November 7, 2007 1:17:44 AM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:18:20 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:18:30 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kcw.
| PDB = {{PDB2|1kcw}}, {{PDB2|2j5w}}
| Name = Ceruloplasmin (ferroxidase)
| HGNCid = 2295
| Symbol = CP
| AltSymbols =; CP-2
| OMIM = 117700
| ECnumber =
| Homologene = 75
| MGIid = 88476
| GeneAtlas_image1 = PBB_GE_CP_204846_at_tn.png
| Function = {{GNF_GO|id=GO:0004322 |text = ferroxidase activity}} {{GNF_GO|id=GO:0005375 |text = copper ion transmembrane transporter activity}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006825 |text = copper ion transport}} {{GNF_GO|id=GO:0006878 |text = cellular copper ion homeostasis}} {{GNF_GO|id=GO:0006879 |text = cellular iron ion homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1356
| Hs_Ensembl = ENSG00000047457
| Hs_RefseqProtein = NP_000087
| Hs_RefseqmRNA = NM_000096
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 150374067
| Hs_GenLoc_end = 150422269
| Hs_Uniprot = P00450
| Mm_EntrezGene = 12870
| Mm_Ensembl = ENSMUSG00000003617
| Mm_RefseqmRNA = NM_001042611
| Mm_RefseqProtein = NP_001036076
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 20149205
| Mm_GenLoc_end = 20200943
| Mm_Uniprot = Q2F3J4
}}
}}
'''Ceruloplasmin (ferroxidase)''', also known as '''CP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin. The deficiency of this metalloprotein, termed aceruloplasminemia, leads to iron accumulation and tissue damage, and is associated diabetes and neurologic diseases.<ref>{{cite web | title = Entrez Gene: CP ceruloplasmin (ferroxidase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1356| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gitlin JD |title=Aceruloplasminemia. |journal=Pediatr. Res. |volume=44 |issue= 3 |pages= 271-6 |year= 1998 |pmid= 9727700 |doi= }}
*{{cite journal | author=Hellman NE, Gitlin JD |title=Ceruloplasmin metabolism and function. |journal=Annu. Rev. Nutr. |volume=22 |issue= |pages= 439-58 |year= 2002 |pmid= 12055353 |doi= 10.1146/annurev.nutr.22.012502.114457 }}
*{{cite journal | author=Mazumder B, Seshadri V, Fox PL |title=Translational control by the 3'-UTR: the ends specify the means. |journal=Trends Biochem. Sci. |volume=28 |issue= 2 |pages= 91-8 |year= 2003 |pmid= 12575997 |doi= }}
*{{cite journal | author=Giurgea N, Constantinescu MI, Stanciu R, ''et al.'' |title=Ceruloplasmin - acute-phase reactant or endogenous antioxidant? The case of cardiovascular disease. |journal=Med. Sci. Monit. |volume=11 |issue= 2 |pages= RA48-51 |year= 2005 |pmid= 15668644 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CTNND1... {November 7, 2007 1:19:39 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:20:01 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Catenin (cadherin-associated protein), delta 1
| HGNCid = 2515
| Symbol = CTNND1
| AltSymbols =; CAS; CTNND; KIAA0384; P120CAS; P120CTN; p120
| OMIM = 601045
| ECnumber =
| Homologene = 1017
| MGIid = 105100
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0016337 |text = cell-cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1500
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001126721
| Hs_RefseqmRNA = XM_001126721
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 12388
| Mm_Ensembl = ENSMUSG00000034101
| Mm_RefseqmRNA = NM_007615
| Mm_RefseqProtein = NP_031641
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 84401622
| Mm_GenLoc_end = 84451514
| Mm_Uniprot = Q3TSU9
}}
}}
'''Catenin (cadherin-associated protein), delta 1''', also known as '''CTNND1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and althernative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.<ref>{{cite web | title = Entrez Gene: CTNND1 catenin (cadherin-associated protein), delta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1500| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wijnhoven BP, Dinjens WN, Pignatelli M |title=E-cadherin-catenin cell-cell adhesion complex and human cancer. |journal=The British Journal of Surgery |volume=87 |issue= 8 |pages= 992-1005 |year= 2000 |pmid= 10931041 |doi= 10.1046/j.1365-2168.2000.01513.x }}
*{{cite journal | author=Thoreson MA, Reynolds AB |title=Altered expression of the catenin p120 in human cancer: implications for tumor progression. |journal=Differentiation |volume=70 |issue= 9-10 |pages= 583-9 |year= 2003 |pmid= 12492499 |doi= }}
*{{cite journal | author=Reynolds AB, Carnahan RH |title=Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer. |journal=Semin. Cell Dev. Biol. |volume=15 |issue= 6 |pages= 657-63 |year= 2005 |pmid= 15561585 |doi= 10.1016/j.semcdb.2004.09.003 }}
*{{cite journal | author=Keil R, Wolf A, Hüttelmaier S, Hatzfeld M |title=Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin. |journal=Cell Cycle |volume=6 |issue= 2 |pages= 122-7 |year= 2007 |pmid= 17264675 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CX3CL1... {November 7, 2007 1:28:21 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CX3CL1 image.jpg {November 7, 2007 1:29:09 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:29:32 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CX3CL1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b2t.
| PDB = {{PDB2|1b2t}}, {{PDB2|1f2l}}
| Name = Chemokine (C-X3-C motif) ligand 1
| HGNCid = 10647
| Symbol = CX3CL1
| AltSymbols =; NTN; ABCD-3; C3Xkine; CXC3; CXC3C; NTT; SCYD1; fractalkine; neurotactin
| OMIM = 601880
| ECnumber =
| Homologene = 2251
| MGIid = 1097153
| GeneAtlas_image1 = PBB_GE_CX3CL1_823_at_tn.png
| GeneAtlas_image2 = PBB_GE_CX3CL1_203687_at_tn.png
| Function = {{GNF_GO|id=GO:0008009 |text = chemokine activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}} {{GNF_GO|id=GO:0030595 |text = leukocyte chemotaxis}} {{GNF_GO|id=GO:0050729 |text = positive regulation of inflammatory response}} {{GNF_GO|id=GO:0050902 |text = leukocyte adhesive activation}} {{GNF_GO|id=GO:0051041 |text = positive regulation of calcium-independent cell-cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6376
| Hs_Ensembl = ENSG00000006210
| Hs_RefseqProtein = NP_002987
| Hs_RefseqmRNA = NM_002996
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 55963900
| Hs_GenLoc_end = 55976455
| Hs_Uniprot = P78423
| Mm_EntrezGene = 20312
| Mm_Ensembl = ENSMUSG00000031778
| Mm_RefseqmRNA = NM_009142
| Mm_RefseqProtein = NP_033168
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 97661333
| Mm_GenLoc_end = 97671552
| Mm_Uniprot = Q8C9Y1
}}
}}
'''Chemokine (C-X3-C motif) ligand 1''', also known as '''CX3CL1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Umehara H, Bloom ET, Okazaki T, ''et al.'' |title=Fractalkine in vascular biology: from basic research to clinical disease. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 1 |pages= 34-40 |year= 2004 |pmid= 12969992 |doi= 10.1161/01.ATV.0000095360.62479.1F }}
*{{cite journal | author=Umehara H, Tanaka M, Sawaki T, ''et al.'' |title=Fractalkine in rheumatoid arthritis and allied conditions. |journal=Mod Rheumatol |volume=16 |issue= 3 |pages= 124-30 |year= 2006 |pmid= 16767549 |doi= 10.1007/s10165-006-0471-9 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CYP1B1... {November 7, 2007 1:20:01 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:21:31 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cytochrome P450, family 1, subfamily B, polypeptide 1
| HGNCid = 2597
| Symbol = CYP1B1
| AltSymbols =; CP1B; GLC3A
| OMIM = 601771
| ECnumber =
| Homologene = 68035
| MGIid = 88590
| GeneAtlas_image1 = PBB_GE_CYP1B1_202437_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CYP1B1_202434_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CYP1B1_202435_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050381 |text = unspecific monooxygenase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0007601 |text = visual perception}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1545
| Hs_Ensembl = ENSG00000138061
| Hs_RefseqProtein = NP_000095
| Hs_RefseqmRNA = NM_000104
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 38148154
| Hs_GenLoc_end = 38156796
| Hs_Uniprot = Q16678
| Mm_EntrezGene = 13078
| Mm_Ensembl = ENSMUSG00000024087
| Mm_RefseqmRNA = NM_009994
| Mm_RefseqProtein = NP_034124
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 79615279
| Mm_GenLoc_end = 79623367
| Mm_Uniprot = Q3UTK2
}}
}}
'''Cytochrome P450, family 1, subfamily B, polypeptide 1''', also known as '''CYP1B1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.<ref>{{cite web | title = Entrez Gene: CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1545| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=Sasaki M, Kaneuchi M, Fujimoto S, ''et al.'' |title=CYP1B1 gene in endometrial cancer. |journal=Mol. Cell. Endocrinol. |volume=202 |issue= 1-2 |pages= 171-6 |year= 2004 |pmid= 12770747 |doi= }}
*{{cite journal | author=Nelson DR, Zeldin DC, Hoffman SM, ''et al.'' |title=Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. |journal=Pharmacogenetics |volume=14 |issue= 1 |pages= 1-18 |year= 2004 |pmid= 15128046 |doi= }}
*{{cite journal | author=Paracchini V, Raimondi S, Gram IT, ''et al.'' |title=Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review. |journal=Am. J. Epidemiol. |volume=165 |issue= 2 |pages= 115-25 |year= 2007 |pmid= 17053044 |doi= 10.1093/aje/kwj365 }}
*{{cite journal | author=Coca-Prados M, Escribano J |title=New perspectives in aqueous humor secretion and in glaucoma: the ciliary body as a multifunctional neuroendocrine gland. |journal=Progress in retinal and eye research |volume=26 |issue= 3 |pages= 239-62 |year= 2007 |pmid= 17321191 |doi= 10.1016/j.preteyeres.2007.01.002 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CYP3A5... {November 7, 2007 1:21:31 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:22:24 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cytochrome P450, family 3, subfamily A, polypeptide 5
| HGNCid = 2638
| Symbol = CYP3A5
| AltSymbols =; CP35; P450PCN3; PCN3
| OMIM = 605325
| ECnumber =
| Homologene = 88340
| MGIid = 88609
| GeneAtlas_image1 = PBB_GE_CYP3A5_205765_at_tn.png
| GeneAtlas_image2 = PBB_GE_CYP3A5_214234_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050381 |text = unspecific monooxygenase activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006805 |text = xenobiotic metabolic process}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1577
| Hs_Ensembl = ENSG00000106258
| Hs_RefseqProtein = NP_000768
| Hs_RefseqmRNA = NM_000777
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 99083759
| Hs_GenLoc_end = 99115557
| Hs_Uniprot = P20815
| Mm_EntrezGene = 13112
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_984479
| Mm_RefseqProtein = XP_989573
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Cytochrome P450, family 3, subfamily A, polypeptide 5''', also known as '''CYP3A5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene.<ref>{{cite web | title = Entrez Gene: CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1577| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=Lee SJ, Goldstein JA |title=Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests. |journal=Pharmacogenomics |volume=6 |issue= 4 |pages= 357-71 |year= 2006 |pmid= 16004554 |doi= 10.1517/14622416.6.4.357 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ERCC3... {November 7, 2007 1:22:24 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:23:02 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)
| HGNCid = 3435
| Symbol = ERCC3
| AltSymbols =; BTF2; GTF2H; RAD25; TFIIH; XPB
| OMIM = 133510
| ECnumber =
| Homologene = 96
| MGIid = 95414
| GeneAtlas_image1 = PBB_GE_ERCC3_202176_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0004003 |text = ATP-dependent DNA helicase activity}} {{GNF_GO|id=GO:0004386 |text = helicase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0043138 |text = 3' to 5' DNA helicase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005675 |text = holo TFIIH complex}}
| Process = {{GNF_GO|id=GO:0006265 |text = DNA topological change}} {{GNF_GO|id=GO:0006283 |text = transcription-coupled nucleotide-excision repair}} {{GNF_GO|id=GO:0006289 |text = nucleotide-excision repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2071
| Hs_Ensembl = ENSG00000163161
| Hs_RefseqProtein = NP_000113
| Hs_RefseqmRNA = NM_000122
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 127731336
| Hs_GenLoc_end = 127768222
| Hs_Uniprot = P19447
| Mm_EntrezGene = 13872
| Mm_Ensembl = ENSMUSG00000024382
| Mm_RefseqmRNA = NM_133658
| Mm_RefseqProtein = NP_598419
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 32383341
| Mm_GenLoc_end = 32413157
| Mm_Uniprot = Q3TVD8
}}
}}
'''Excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)''', also known as '''ERCC3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription.<ref>{{cite web | title = Entrez Gene: ERCC3 excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2071| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Jeang KT |title=Tat, Tat-associated kinase, and transcription. |journal=J. Biomed. Sci. |volume=5 |issue= 1 |pages= 24-7 |year= 1998 |pmid= 9570510 |doi= }}
*{{cite journal | author=Yankulov K, Bentley D |title=Transcriptional control: Tat cofactors and transcriptional elongation. |journal=Curr. Biol. |volume=8 |issue= 13 |pages= R447-9 |year= 1998 |pmid= 9651670 |doi= }}
*{{cite journal | author=Cleaver JE, Thompson LH, Richardson AS, States JC |title=A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. |journal=Hum. Mutat. |volume=14 |issue= 1 |pages= 9-22 |year= 1999 |pmid= 10447254 |doi= 10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GLRA1... {November 7, 2007 1:23:02 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:23:39 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome)
| HGNCid = 4326
| Symbol = GLRA1
| AltSymbols =; MGC138878; MGC138879; STHE
| OMIM = 138491
| ECnumber =
| Homologene = 20083
| MGIid = 95747
| GeneAtlas_image1 = PBB_GE_GLRA1_207972_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004890 |text = GABA-A receptor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005230 |text = extracellular ligand-gated ion channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016594 |text = glycine binding}} {{GNF_GO|id=GO:0016934 |text = extracellular-glycine-gated chloride channel activity}} {{GNF_GO|id=GO:0030594 |text = neurotransmitter receptor activity}} {{GNF_GO|id=GO:0030977 |text = taurine binding}} {{GNF_GO|id=GO:0031404 |text = chloride ion binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0043231 |text = intracellular membrane-bound organelle}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0001964 |text = startle response}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006821 |text = chloride transport}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0042391 |text = regulation of membrane potential}} {{GNF_GO|id=GO:0051970 |text = negative regulation of transmission of nerve impulse}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2741
| Hs_Ensembl = ENSG00000145888
| Hs_RefseqProtein = NP_000162
| Hs_RefseqmRNA = NM_000171
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 151182361
| Hs_GenLoc_end = 151284596
| Hs_Uniprot = P23415
| Mm_EntrezGene = 14654
| Mm_Ensembl = ENSMUSG00000000263
| Mm_RefseqmRNA = XM_990138
| Mm_RefseqProtein = XP_995232
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 55357661
| Mm_GenLoc_end = 55451621
| Mm_Uniprot = Q5NCT8
}}
}}
'''Glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome)''', also known as '''GLRA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha and beta subunits. The GLRB gene (MIM 138492) encodes the beta subunit of the receptor.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: GLRA1 glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2741| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on JAG1... {November 7, 2007 1:07:56 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:09:34 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Jagged 1 (Alagille syndrome)
| HGNCid = 6188
| Symbol = JAG1
| AltSymbols =; AGS; AHD; AWS; CD339; HJ1; JAGL1; MGC104644
| OMIM = 601920
| ECnumber =
| Homologene = 180
| MGIid = 1095416
| GeneAtlas_image1 = PBB_GE_JAG1_216268_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_JAG1_209097_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_JAG1_209098_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005112 |text = Notch binding}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0001709 |text = cell fate determination}} {{GNF_GO|id=GO:0002011 |text = morphogenesis of an epithelial sheet}} {{GNF_GO|id=GO:0007154 |text = cell communication}} {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0030097 |text = hemopoiesis}} {{GNF_GO|id=GO:0030216 |text = keratinocyte differentiation}} {{GNF_GO|id=GO:0030334 |text = regulation of cell migration}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}} {{GNF_GO|id=GO:0042491 |text = auditory receptor cell differentiation}} {{GNF_GO|id=GO:0045445 |text = myoblast differentiation}} {{GNF_GO|id=GO:0045446 |text = endothelial cell differentiation}} {{GNF_GO|id=GO:0045596 |text = negative regulation of cell differentiation}} {{GNF_GO|id=GO:0045639 |text = positive regulation of myeloid cell differentiation}} {{GNF_GO|id=GO:0045747 |text = positive regulation of Notch signaling pathway}} {{GNF_GO|id=GO:0048839 |text = inner ear development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 182
| Hs_Ensembl = ENSG00000101384
| Hs_RefseqProtein = NP_000205
| Hs_RefseqmRNA = NM_000214
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 10566334
| Hs_GenLoc_end = 10602636
| Hs_Uniprot = P78504
| Mm_EntrezGene = 16449
| Mm_Ensembl = ENSMUSG00000027276
| Mm_RefseqmRNA = XM_990538
| Mm_RefseqProtein = XP_995632
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 136772899
| Mm_GenLoc_end = 136807772
| Mm_Uniprot = Q3TS72
}}
}}
'''Jagged 1 (Alagille syndrome)''', also known as '''JAG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.<ref>{{cite web | title = Entrez Gene: JAG1 jagged 1 (Alagille syndrome)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=182| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Piccoli DA, Spinner NB |title=Alagille syndrome and the Jagged1 gene. |journal=Semin. Liver Dis. |volume=21 |issue= 4 |pages= 525-34 |year= 2002 |pmid= 11745040 |doi= 10.1055/s-2001-19036 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NFATC2... {November 7, 2007 1:23:39 AM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:23:56 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:24:09 AM PST}
- CREATED: Created new protein page: NFATC2 {November 7, 2007 1:24:16 AM PST}
- INFO: Beginning work on P2RX7... {November 7, 2007 1:24:16 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:24:52 AM PST}
- CREATED: Created new protein page: P2RX7 {November 7, 2007 1:25:00 AM PST}
- INFO: Beginning work on POLR2F... {November 7, 2007 1:25:00 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein POLR2F image.jpg {November 7, 2007 1:25:34 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:25:53 AM PST}
- CREATED: Created new protein page: POLR2F {November 7, 2007 1:26:00 AM PST}
- INFO: Beginning work on POLR2L... {November 7, 2007 1:26:00 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:27:05 AM PST}
- CREATED: Created new protein page: POLR2L {November 7, 2007 1:27:13 AM PST}
- INFO: Beginning work on S100A9... {November 7, 2007 1:27:13 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein S100A9 image.jpg {November 7, 2007 1:27:50 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:28:21 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_S100A9_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1irj.
| PDB = {{PDB2|1irj}}, {{PDB2|1xk4}}
| Name = S100 calcium binding protein A9
| HGNCid = 10499
| Symbol = S100A9
| AltSymbols =; MIF; 60B8AG; CFAG; NIF; CAGB; CGLB; L1AG; LIAG; MAC387; MRP14; P14
| OMIM = 123886
| ECnumber =
| Homologene = 2227
| MGIid = 1338947
| GeneAtlas_image1 = PBB_GE_S100A9_203535_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6280
| Hs_Ensembl = ENSG00000163220
| Hs_RefseqProtein = NP_002956
| Hs_RefseqmRNA = NM_002965
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 151596954
| Hs_GenLoc_end = 151600127
| Hs_Uniprot = P06702
| Mm_EntrezGene = 20202
| Mm_Ensembl = ENSMUSG00000056071
| Mm_RefseqmRNA = NM_009114
| Mm_RefseqProtein = NP_033140
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 90778560
| Mm_GenLoc_end = 90781618
| Mm_Uniprot = Q3UP42
}}
}}
'''S100 calcium binding protein A9''', also known as '''S100A9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis.<ref>{{cite web | title = Entrez Gene: S100A9 S100 calcium binding protein A9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6280| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134-40 |year= 1996 |pmid= 8701470 |doi= }}
*{{cite journal | author=Kerkhoff C, Klempt M, Sorg C |title=Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). |journal=Biochim. Biophys. Acta |volume=1448 |issue= 2 |pages= 200-11 |year= 1999 |pmid= 9920411 |doi= }}
*{{cite journal | author=Nacken W, Roth J, Sorg C, Kerkhoff C |title=S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity. |journal=Microsc. Res. Tech. |volume=60 |issue= 6 |pages= 569-80 |year= 2003 |pmid= 12645005 |doi= 10.1002/jemt.10299 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SPI1... {November 7, 2007 1:29:32 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SPI1 image.jpg {November 7, 2007 1:30:02 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:30:21 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SPI1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1pue.
| PDB = {{PDB2|1pue}}
| Name = Spleen focus forming virus (SFFV) proviral integration oncogene spi1
| HGNCid = 11241
| Symbol = SPI1
| AltSymbols =; OF; PU.1; SFPI1; SPI-1; SPI-A
| OMIM = 165170
| ECnumber =
| Homologene = 2346
| MGIid = 98282
| GeneAtlas_image1 = PBB_GE_SPI1_205312_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0030098 |text = lymphocyte differentiation}} {{GNF_GO|id=GO:0030225 |text = macrophage differentiation}} {{GNF_GO|id=GO:0030851 |text = granulocyte differentiation}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6688
| Hs_Ensembl = ENSG00000066336
| Hs_RefseqProtein = NP_001074016
| Hs_RefseqmRNA = NM_001080547
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 47332988
| Hs_GenLoc_end = 47356674
| Hs_Uniprot = P17947
| Mm_EntrezGene = 20375
| Mm_Ensembl = ENSMUSG00000002111
| Mm_RefseqmRNA = XM_001003437
| Mm_RefseqProtein = XP_001003437
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 90897636
| Mm_GenLoc_end = 90916595
| Mm_Uniprot = Q3U5L4
}}
}}
'''Spleen focus forming virus (SFFV) proviral integration oncogene spi1''', also known as '''SPI1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6688| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on YY1... {November 7, 2007 1:30:21 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein YY1 image.jpg {November 7, 2007 1:31:12 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:31:28 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_YY1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ubd.
| PDB = {{PDB2|1ubd}}
| Name = YY1 transcription factor
| HGNCid = 12856
| Symbol = YY1
| AltSymbols =; DELTA; NF-E1; UCRBP; YIN-YANG-1
| OMIM = 600013
| ECnumber =
| Homologene = 2556
| MGIid = 99150
| GeneAtlas_image1 = PBB_GE_YY1_201901_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_YY1_201902_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}} {{GNF_GO|id=GO:0031519 |text = PcG protein complex}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0009952 |text = anterior/posterior pattern formation}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7528
| Hs_Ensembl = ENSG00000100811
| Hs_RefseqProtein = NP_003394
| Hs_RefseqmRNA = NM_003403
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 99774855
| Hs_GenLoc_end = 99814557
| Hs_Uniprot = P25490
| Mm_EntrezGene = 22632
| Mm_Ensembl = ENSMUSG00000021264
| Mm_RefseqmRNA = NM_009537
| Mm_RefseqProtein = NP_033563
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 109241118
| Mm_GenLoc_end = 109264439
| Mm_Uniprot = Q3TLF0
}}
}}
'''YY1 transcription factor''', also known as '''YY1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.<ref>{{cite web | title = Entrez Gene: YY1 YY1 transcription factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7528| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Thomas MJ, Seto E |title=Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key? |journal=Gene |volume=236 |issue= 2 |pages= 197-208 |year= 1999 |pmid= 10452940 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
