User:Mr. Ibrahem/Varenicline

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Mr. Ibrahem/Varenicline
Clinical data
Trade namesChampix, Chantix, others
AHFS/Drugs.comMonograph
MedlinePlusa606024
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth
Legal status
Legal status
Pharmacokinetic data
Protein binding<20%
MetabolismLimited (<10%)
Elimination half-life24 hours
ExcretionKidney (81–92%)
Identifiers
  • 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h] [3]benzazepine
Chemical and physical data
FormulaC13H13N3
Molar mass211.267 g·mol−1
3D model (JSmol)
  • n1c2cc3c(cc2ncc1)[C@@H]4CNC[C@H]3C4
  • InChI=1S/C13H13N3/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1/h1-2,4-5,8-9,14H,3,6-7H2/t8-,9+ checkY
  • Key:JQSHBVHOMNKWFT-DTORHVGOSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Varenicline, sold under the trade name Champix among others, is a medication used help people stop smoking.[1] It is the recommended initial treatment together with behavioral support.[2][3] It helps one of every 11 people who smoke, stop for at least six months.[4] Varenicline is taken by mouth.[1]

Common side effects include unusual dreams, nausea, and constipation.[1] Serious side effects may include depression, anxiety, seeing or hearing things that others do not, allergic reactions, thoughts of suicide, and seizures.[1] There is no clear harm from use in human pregnancy but such use has not been well studied and there may be harm in pregnancy in other animals.[5] It works by binding to a type of nicotinic acetylcholine receptors in the brain, decreasing the ability of nicotine to attach, and thus reducing the desire to smoke.[1]

Varenicline was approved for medical use in the United States and Europe in 2006.[1][6] As of 2020 it costs about 440 USD in the United States for the first month (7.60 USD per tablet).[7][8] In the United Kingdom this amount is about 55 pounds.[3] It may become avaliable as a generic medication in the US in 2020.[7]

References[edit]

  1. ^ a b c d e f "Varenicline tartrate Monograph for Professionals". Drugs.com. Archived from the original on 12 August 2020. Retrieved 19 August 2020.
  2. ^ Leone, Frank T.; Zhang, Yuqing; Evers-Casey, Sarah; Evins, A. Eden; Eakin, Michelle N.; Fathi, Joelle; Fennig, Kathleen; Folan, Patricia; Galiatsatos, Panagis; Gogineni, Hyma; Kantrow, Stephen; Kathuria, Hasmeena; Lamphere, Thomas; Neptune, Enid; Pacheco, Manuel C.; Pakhale, Smita; Prezant, David; Sachs, David P. L.; Toll, Benjamin; Upson, Dona; Xiao, Dan; Cruz-Lopes, Luciane; Fulone, Izabela; Murray, Rachael L.; O’Brien, Kelly K.; Pavalagantharajah, Sureka; Ross, Stephanie; Zhang, Yuan; Zhu, Meng; Farber, Harold J. (15 July 2020). "Initiating Pharmacologic Treatment in Tobacco-Dependent Adults. An Official American Thoracic Society Clinical Practice Guideline". American Journal of Respiratory and Critical Care Medicine. 202 (2): e5–e31. doi:10.1164/rccm.202005-1982ST.
  3. ^ a b BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 515. ISBN 9780857113658.
  4. ^ Crawford, P; Cieslak, D (September 2017). "Varenicline for Smoking Cessation". American Family Physician. 96 (5): Online. PMID 28925657. Archived from the original on 2019-05-26. Retrieved 2019-05-26.
  5. ^ "Varenicline Use During Pregnancy". Drugs.com. Archived from the original on 27 January 2021. Retrieved 19 August 2020.
  6. ^ European Medicines Agency (2011-01-28). "EPAR summary for the public. Champix varenicline". London. Archived from the original on 2011-07-20. Retrieved 2011-02-14.
  7. ^ a b "Varenicline Prices, Coupons & Savings Tips". GoodRx. Retrieved 19 August 2020.
  8. ^ "NADAC as of 2020-08-19 | Data.Medicaid.gov". Centers for Medicare and Medicaid Services. Retrieved 19 August 2020.{{cite web}}: CS1 maint: url-status (link)
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