User:Mr. Ibrahem/Selegiline

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Mr. Ibrahem/Selegiline
Clinical data
Pronunciation/səˈlɛdʒɪliːn/ sə-LEJ-i-leen
Trade namesEldepryl, Jumex, Zelapar, Emsam, others[1]
Other namesL-Deprenyl; (R)-(–)-N,α-Dimethyl-N-2-propynylphenethylamine; (R)-(–)-N-Methyl-N-2-propynylamphetamine; (R)-(–)-N-2-propynylmethamphetamine
AHFS/Drugs.comMonograph
MedlinePlusa697046
License data
Pregnancy
category
  • AU: B2
Routes of
administration		By mouth, skin (patch)
Drug classMonoamine oxidase inhibitor[2]
Legal status
Legal status
Pharmacokinetic data
Bioavailability10% (by mouth), 73% (patch)
Protein binding94%
MetabolismIntestines and liver
MetabolitesN-Desmethylselegiline, levoamphetamine, levomethamphetamine
Elimination half-life1.5–3.5 hours (oral),[3] 18–25 hours (transdermal)[4]
ExcretionUrine
Identifiers
  • (R)-N-methyl-N-(1-pheny lpropan-2-yl)prop-3-yn-1-amine
Chemical and physical data
FormulaC13H17N
Molar mass187.281 g·mol−1
3D model (JSmol)
  • C#CCN([C@@H](Cc1ccccc1)C)C
  • InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/m1/s1 checkY
  • Key:MEZLKOACVSPNER-GFCCVEGCSA-N checkY
  (verify)

Selegiline, sold under the brand names Eldepryl among others, is a medication used to treat parkinsonism including in Parkinson's disease and major depressive disorder.[5][2][6] It is used by mouth or as a patch applied to skin.[2][6]

When taken by mouth, common side effects include nausea, lightheadedness, dry mouth, headache, and hallucinations.[5] When applied as a patch, common side effects include trouble sleeping, rash, and a stuffy nose.[6] Other side effects may include serotonin syndrome, low blood pressure, urge to gamble, neuroleptic malignant syndrome, and sudden onset of sleep.[5] It is a monoamine oxidase B inhibitor at lower doses, while at higher doses it is also a monoamine oxidase A inhibitor.[2][5] It works by increasing brain levels of dopamine and serotonin.[6][5]

Selegilinewas approved for medical use in the United States in 1989.[5] In the United Kingdom 100 tablets of 10 mg costs the NHS about £32 as of 2021.[2] This amount in the United States costs about 130 USD.[7] In the United States a month of patches costs about 1,800 USD.[8]

References[edit]

  1. ^ "Selegiline". Drugs.com. Archived from the original on December 29, 2019. Retrieved February 7, 2016.
  2. ^ a b c d e f BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 447. ISBN 978-0-85711-369-6.
  3. ^ "Archive copy". Archived from the original on April 16, 2015. Retrieved July 10, 2021.{{cite web}}: CS1 maint: archived copy as title (link)
  4. ^ "Archive copy" (PDF). Archived (PDF) from the original on April 3, 2021. Retrieved July 10, 2021.{{cite web}}: CS1 maint: archived copy as title (link)
  5. ^ a b c d e f g h "Selegiline Monograph for Professionals". Drugs.com. Archived from the original on August 13, 2020. Retrieved October 11, 2021.
  6. ^ a b c d e "EMSAM® (selegiline transdermal system)" (PDF). Archived (PDF) from the original on August 10, 2021. Retrieved October 11, 2021.
  7. ^ "Selegiline Prices and Selegiline Coupons - GoodRx". GoodRx. Retrieved October 11, 2021.
  8. ^ "Emsam Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on November 15, 2016. Retrieved October 11, 2021.
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