User:Mr. Ibrahem/Secnidazole

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Mr. Ibrahem/Secnidazole
Clinical data
Trade namesSolosec, Flagentyl, Sindil, others[1]
Other namesPM 185184, RP 14539
AHFS/Drugs.comMonograph
Routes of
administration
By mouth
Drug classNitroimidazole[2]
Legal status
Legal status
Identifiers
  • 1-(2-Methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
Chemical and physical data
FormulaC7H11N3O3
Molar mass185.183 g·mol−1
3D model (JSmol)
  • [O-][N+](=O)c1cnc(n1CC(O)C)C
  • InChI=1S/C7H11N3O3/c1-5(11)4-9-6(2)8-3-7(9)10(12)13/h3,5,11H,4H2,1-2H3 checkY
  • Key:KPQZUUQMTUIKBP-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Secnidazole, sold under the brand name Solosec among others, is an antimicrobial used to treat bacterial vaginosis and trichomonas vaginitis.[2][3] It is taken by mouth.[2]

Common side effects include vaginal yeast infection, headache, nausea, diarrhea, and abdominal pain.[2] Other side effects may include Safety in pregnancy and breastfeeding is unclear.[2] It is a nitroimidazole whose mechanism of action is not entirely clear.[2]

Secnidazole was approved for medical use in the United States in 2017.[2] In the United States a single dose costs about 280 USD as of 2021.[4] It has; however, been available in other parts of the world for decades.[5]

References[edit]

  1. ^ Society, Swiss Pharmaceutical (2000). Index Nominum 2000: International Drug Directory. Taylor & Francis. p. 938. ISBN 978-3-88763-075-1. Archived from the original on 2021-10-12. Retrieved 2021-10-11.
  2. ^ a b c d e f g h i j "Secnidazole Monograph for Professionals". Drugs.com. Retrieved 11 October 2021.
  3. ^ kumar, Sunesh; Padubidri, V. G.; Daftary, Shirish N. (24 July 2018). Howkins & Bourne, Shaw's Textbook of Gynecology, 17edition-EBOOK. Elsevier Health Sciences. p. 365. ISBN 978-81-312-5412-7. Archived from the original on 12 October 2021. Retrieved 11 October 2021.
  4. ^ "Secnidazole Prices and Secnidazole Coupons - GoodRx". GoodRx. Retrieved 11 October 2021.
  5. ^ Nyirjesy, P; Schwebke, JR (April 2018). "Secnidazole: next-generation antimicrobial agent for bacterial vaginosis treatment". Future microbiology. 13: 507–524. doi:10.2217/fmb-2017-0270. PMID 29327947.