User:Mr. Ibrahem/Probenecid
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| Clinical data | |
|---|---|
| Trade names | Probalan |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682395 |
| Routes of administration | By mouth |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Protein binding | 75-95% |
| Elimination half-life | 2-6 hours (dose: 0.5-1 g) |
| Excretion | kidney (77-88%) |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C13H19NO4S |
| Molar mass | 285.36 g·mol−1 |
| 3D model (JSmol) | |
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| (verify) | |
Probenecid, also sold under the brand name Probalan, is a medication primarily used to treat hyperuricemia including in gout.[1] It is also used to decrease the clearance of β-lactam antibiotics and cidofovir.[1] It is taken by mouth.[1]
Common side effects include headache, vomiting, and nausea.[1] Other side effects may include allergic reactions, kidney stones, and a worsened gout attack if started during the attack.[1] Use in pregnancy appears to be safe, though such use has not been well studied.[2] It works by blocking the ability of the kidney to reabsorb urate.[1]
Probenecid was initially developed during World War II to extend penicillin supplies.[3] It was approved for medical use in the United States in 1951 and is available as a generic medication.[1] In the United States 100 tablets of 500 mg costs about 78 USD as of 2021.[4]
References[edit]
- ^ a b c d e f g h i "Probenecid Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 29 October 2021.
- ^ "Probenecid (Benemid) Use During Pregnancy". Drugs.com. Archived from the original on 29 November 2020. Retrieved 29 October 2021.
- ^ Butler D (2005). "Wartime tactic doubles power of scarce bird-flu drug". Nature. 438 (7064): 6. doi:10.1038/438006a. PMID 16267514.
- ^ "Probenecid Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 28 January 2021. Retrieved 29 October 2021.