User:Mr. Ibrahem/Pitavastatin

Mr. Ibrahem/Pitavastatin
Clinical data
Trade names	Livalo, Livazo, Zypitamag, others
AHFS/Drugs.com	Monograph
MedlinePlus	a610018
License data	US FDA: Pitavastatin;
Pregnancy; category	AU: D; ;
Routes of; administration	By mouth (tablets)
Drug class	Statin
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	60%
Protein binding	96%
Metabolism	Liver (CYP2C9, minimally)
Elimination half-life	11 hours
Excretion	Faeces
Identifiers
	IUPAC name (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid;
Chemical and physical data
Formula	C25H24FNO4
Molar mass	421.461 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)C[C@H](O)C[C@H](O)/C=C/c1c(c3ccccc3nc1C2CC2)c4ccc(F)cc4;
	InChI InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/b12-11+/t18-,19-/m1/s1 ; Key:VGYFMXBACGZSIL-MCBHFWOFSA-N ;
	(what is this?) (verify)

Pitavastatin, sold under the brand name Livalo among others is a medication used to treat abnormal lipid levels and reduce the risk of heart disease.^[1] It is taken by mouth.^[1]

Common side effects include muscle pain and diarrhea.^[1] Other side effects may include muscle breakdown with kidney problems, liver problems, diabetes, allergic reactions, and memory problems.^[1] Use in pregnancy may harm the baby.^[1] It is a statin and works by blocking HMG-CoA reductase.^[1]

Pitavastatin was patented in 1987 and approved for medical use in 2003.^[2] It was approved in the United States in 2009.^[1] It is available in a number of countries in Europe.^[3] In the United States 3 month of medication costs about 1,000 USD as of 2021.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Pitavastatin Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 28 October 2021.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 473. ISBN 9783527607495. Archived from the original on 16 May 2021. Retrieved 18 October 2021.
^ "List of nationally authorised medicinal products" (PDF). Archived (PDF) from the original on 28 October 2021. Retrieved 28 October 2021.
^ "Livalo Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 10 May 2016. Retrieved 28 October 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Pitavastatin Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 28 October 2021.

[Fis2006-2] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 473. ISBN 9783527607495. Archived from the original on 16 May 2021. Retrieved 18 October 2021.

[3] "List of nationally authorised medicinal products" (PDF). Archived (PDF) from the original on 28 October 2021. Retrieved 28 October 2021.

[4] "Livalo Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 10 May 2016. Retrieved 28 October 2021.

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