User:Mr. Ibrahem/Piroxicam

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Mr. Ibrahem/Piroxicam
Skeletal formula of piroxicam
Space-filling model of the piroxicam molecule
Clinical data
Pronunciation/paɪˈrɒksɪˌkæm/
Trade namesFeldene, others[1]
Other namesPiroksikam, piroxikam
AHFS/Drugs.comMonograph
MedlinePlusa684045
Pregnancy
category
  • AU: C
Routes of
administration		By mouth
Drug classNonsteroidal anti-inflammatory drug (NSAID)
Legal status
Legal status
Pharmacokinetic data
Protein binding99%[3]
MetabolismLiver-mediated hydroxylation and glucuronidation[3]
Elimination half-life50 hours[3]
ExcretionUrine, faeces
Identifiers
  • 4-Hydroxy-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
Chemical and physical data
FormulaC15H13N3O4S
Molar mass331.35 g·mol−1
3D model (JSmol)
  • OC=2c1ccccc1S(=O)(=O)N(C)C=2C(=O)Nc3ccccn3
  • InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20) checkY
  • Key:QYSPLQLAKJAUJT-UHFFFAOYSA-N checkY
  (verify)

Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation.[4] This includes in condition like arthritis and painful periods.[4] It is taken by mouth or applied to the skin.[4][5]

Common side effects include heartburn, nausea, diarrhea, rash, headache, swelling, and ringing in the ears.[4] Other side effects may include anaphylaxis, kidney problems, gastrointestinal bleeding, heart disease, heart failure, and high blood pressure.[4] Use in the later part of pregnancy may harm the baby.[4] It is in the oxicam family of medications and works by blocking COX-1 and COX-2.[4]

Piroxicam was patented in 1968 and approved for medical use in 1979.[6] It is available as a generic medication.[5] In the United Kingdom a month of medication costs the NHS about £5 as of 2021.[5] In the United States this amount costs about 30 USD.[7] It is marketed under many brand names.[1]

References[edit]

  1. ^ a b "Piroxicam Uses, Side Effects & Warnings". Drugs.com. Archived from the original on 28 August 2021. Retrieved 28 October 2021.
  2. ^ "Archive copy" (PDF). Archived (PDF) from the original on 2021-08-28. Retrieved 2021-01-28.{{cite web}}: CS1 maint: archived copy as title (link)
  3. ^ a b c Brayfield, A, ed. (14 January 2014). "Piroxicam". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Archived from the original on 28 August 2021. Retrieved 24 June 2014.
  4. ^ a b c d e f g h i "Piroxicam Monograph for Professionals". Drugs.com. Archived from the original on 21 October 2021. Retrieved 28 October 2021.
  5. ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1196. ISBN 978-0857114105.
  6. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 519. ISBN 9783527607495. Archived from the original on 2020-07-10. Retrieved 2020-09-06.
  7. ^ "Piroxicam Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 24 January 2021. Retrieved 28 October 2021.
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