User:Mr. Ibrahem/Pimozide

Mr. Ibrahem/Pimozide
Clinical data
Trade names	Orap
AHFS/Drugs.com	Monograph
MedlinePlus	a686018
License data	US FDA: Pimozide;
Pregnancy; category	AU: B1; ;
Routes of; administration	By mouth
Drug class	Typical antipsychotic
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	40-50%
Metabolism	CYP3A4, CYP1A2 and CYP2D6
Elimination half-life	55 hours (adults), 66 hours (children)
Excretion	Urine
Identifiers
	IUPAC name 1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazole-2-one;
Chemical and physical data
Formula	C28H29F2N3O
Molar mass	461.557 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Fc1ccc(cc1)C(c2ccc(F)cc2)CCCN5CCC(N4c3ccccc3NC4=O)CC5;
	InChI InChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34) ; Key:YVUQSNJEYSNKRX-UHFFFAOYSA-N ;
	(verify)

Pimozide, sold under the brand name Orap among others, is a medication used to treat schizophrenia and Tourette syndrome.^[1]^[2] In Tourette's it is used when other treatments such as haloperidol are not effective.^[2] It is taken by mouth.^[2]

Common side effects include parkinsonism, dry mouth, and sleepiness.^[2] Other side effects may include tardive dyskinesia, neuroleptic malignant syndrome, QT prolongation, and seizures.^[2] It is an antipsychotic in the diphenylbutylpiperidine class.^[2] It affects both dopamine and serotonin receptors.^[3]

Pimozide was patented in 1963 and came into medical use in France in 1969.^[3] In the United Kingdom 100 tablets of 4 mg costs the NHS about £40 as of 2021.^[1] In the United States this amount costs about 430 USD.^[4]

References[edit]

^ ^a ^b ^c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 408. ISBN 978-0857114105.
^ ^a ^b ^c ^d ^e ^f ^g ^h "Pimozide Monograph for Professionals". Drugs.com. Archived from the original on 12 August 2021. Retrieved 28 October 2021.
^ ^a ^b Buschmann, Helmut; Holenz, Jörg; Párraga, Antonio; Torrens, Antoni; Vela, José Miguel; Díaz, José Luis (16 April 2007). Antidepressants, Antipsychotics, Anxiolytics, 2 Volume Set: From Chemistry and Pharmacology to Clinical Application. John Wiley & Sons. p. 528. ISBN 978-3-527-31058-6. Archived from the original on 28 October 2021. Retrieved 28 October 2021.
^ "Pimozide Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 19 April 2021. Retrieved 28 October 2021.

[BNF81-1] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 408. ISBN 978-0857114105.

[AHFS2021-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Pimozide Monograph for Professionals". Drugs.com. Archived from the original on 12 August 2021. Retrieved 28 October 2021.

[Bus2007-3] Buschmann, Helmut; Holenz, Jörg; Párraga, Antonio; Torrens, Antoni; Vela, José Miguel; Díaz, José Luis (16 April 2007). Antidepressants, Antipsychotics, Anxiolytics, 2 Volume Set: From Chemistry and Pharmacology to Clinical Application. John Wiley & Sons. p. 528. ISBN 978-3-527-31058-6. Archived from the original on 28 October 2021. Retrieved 28 October 2021.

[4] "Pimozide Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 19 April 2021. Retrieved 28 October 2021.

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