User:Mr. Ibrahem/Pimecrolimus

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Mr. Ibrahem/Pimecrolimus
Clinical data
Trade namesElidel
AHFS/Drugs.comMonograph
Pregnancy
category
  • AU: B3
Routes of
administration		topical
Drug classCalcineurin inhibitor[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailabilitylow systemic absorption
Protein binding74%–87%
MetabolismHepatic CYP3A
Identifiers
  • (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-{(E)-2-[(1R,3R,4S)-4-chloro-3 -methoxycyclohexyl]-1-methylvinyl}-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosin-1,7,20,21(4H,23H)-tetrone
Chemical and physical data
FormulaC43H68ClNO11
Molar mass810.46 g·mol−1
3D model (JSmol)
  • Cl[C@@H]1CC[C@H](C[C@H]1OC)\C=C(/C)[C@H]2OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@]3(O)O[C@H]([C@H](C[C@@H](C)CC(\C)=C\[C@@H](CC)C(=O)C[C@H](O)[C@H]2C)OC)[C@@H](OC)C[C@H]3C
  • InChI=1S/C43H68ClNO11/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)45-16-12-11-13-32(45)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-31(44)35(22-29)52-7/h18,20,25,27-33,35-39,46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31+,32-,33-,35+,36-,37-,38+,39+,43+/m0/s1 checkY
  • Key:KASDHRXLYQOAKZ-ZPSXYTITSA-N checkY
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Pimecrolimus, sold under the brand name Elidel, is a medication used to treat atopic dermatitis (eczema) and psoriasis.[1][2] It is a second line treatment after topical corticosteroids.[1] It is applied to the skin as a cream.[1]

Common side effects include skin reaction, headache, and cough.[1] Other concerns may include cancer and infections.[1] Use is not recommended in pregnancy.[2] It is a calcineurin inhibitor.[1]

was approved for medical use in the United States in 2001.[1] In the United Kingdom a 30 gram tube costs the NHS about £20 as of 2021.[2] This amount in the United States is about 70 USD.[3]

References[edit]

  1. ^ a b c d e f g h i j k "Pimecrolimus Monograph for Professionals". Drugs.com. Archived from the original on 8 October 2021. Retrieved 28 October 2021.
  2. ^ a b c d BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1299. ISBN 978-0857114105.
  3. ^ "Pimecrolimus Prices and Pimecrolimus Coupons - GoodRx". GoodRx. Archived from the original on 8 May 2016. Retrieved 28 October 2021.
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