User:Mr. Ibrahem/Perampanel

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Mr. Ibrahem/Perampanel
Skeletal formula of perampanel
Ball-and-stick model of the perampanel molecule
Clinical data
Trade namesFycompa
Other namesE2007
AHFS/Drugs.comMonograph
MedlinePlusa614006
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth
Drug classAnticonvulsant (AMPA receptor blocker)[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability116%[6]
Protein binding95–96%
MetabolismHepatic, mostly via CYP3A4 and/or CYP3A5
Elimination half-life105 hours, 295 hours (moderate hepatic impairment)
Excretion70% faeces, 30% urine
Identifiers
  • 5'-(2-cyanophenyl)-1'-phenyl-2,3'-bipyridinyl-6'(1H)-one
Chemical and physical data
FormulaC23H15N3O
Molar mass349.393 g·mol−1
3D model (JSmol)
  • N#Cc2ccccc2-c1cc(-c4ncccc4)cn(c1=O)-c3ccccc3
  • InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22) 16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H ☒N
  • Key:PRMWGUBFXWROHD-UHFFFAOYSA-N ☒N

  • as hydrate: InChI=1S/4C23H15N3O.3H2O/c4*24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19;;;/h4*1-14,16H;3*1H2
  • Key:PDWMJDKMSASBNE-UHFFFAOYSA-N
 ☒NcheckY (what is this?)  (verify)

Perampanel, sold under the brand name Fycompa, is a medication used to treat partial seizures and generalized tonic-clonic seizures.[5] It maybe used in addition to other medications or by itself.[8][7] It is taken by mouth.[7]

Common side effects include sleepiness, irritability, nausea, weight gain, and poor coordination.[7] Other side effects may include homicidal or suicidal thoughts, drug reaction with eosinophilia and systemic symptoms (DRESS), and abuse.[5] It also reduced the effectiveness of birth control containing levonorgestrel.[5] Use during pregnancy may harm the baby.[9] It works by blocking the AMPA receptor.[1]

Perampanel was approved for medical use in the United States and Europe in 2012.[8][5] In the United Kingdom 4 weeks of medication costs the NHS about £140 as of 2021.[10] This amount in the United States costs about 1,000 USD.[11] It is a Schedule III controlled substance by the Drug Enforcement Administration.[5]

References[edit]

  1. ^ a b Chong DJ, Lerman AM (April 2016). "Practice Update: Review of Anticonvulsant Therapy". Current Neurology and Neuroscience Reports. 16 (4): 39. doi:10.1007/s11910-016-0640-y. PMID 26984292. S2CID 9090302.
  2. ^ "AusPAR: Perampanel hemisesquihydrate". Therapeutic Goods Administration (TGA). 10 May 2021. Archived from the original on 13 June 2021. Retrieved 12 June 2021.
  3. ^ https://www.ebs.tga.gov.au/servlet/xmlmillr6?dbid=ebs/PublicHTML/pdfStore.nsf&docid=52B9101BC60D00B2CA25867E003CC743&agid=(PrintDetailsPublic)&actionid=1[permanent dead link]
  4. ^ "TGA eBS - Product and Consumer Medicine Information Licence". Archived from the original on 2021-06-13. Retrieved 2021-09-13.
  5. ^ a b c d e f g h "Fycompa- perampanel tablet Fycompa- perampanel suspension". DailyMed. Archived from the original on 13 June 2021. Retrieved 12 June 2021.
  6. ^ Yang X, Wu TC, Yuxin MA, Lee JY, Bhattaram VA, Mehta MU. "U.S. FDA Clinical Pharmacology Review. Fycompa (perampanel)" (PDF): 25. Archived (PDF) from the original on 2017-05-06. Retrieved 2021-09-13. {{cite journal}}: Cite journal requires |journal= (help)
  7. ^ a b c d "Perampanel Monograph for Professionals". Drugs.com. Archived from the original on 13 June 2021. Retrieved 27 October 2021.
  8. ^ a b "Fycompa". Archived from the original on 19 October 2021. Retrieved 27 October 2021.
  9. ^ "Perampanel (Fycompa) Use During Pregnancy". Drugs.com. Archived from the original on 29 October 2020. Retrieved 27 October 2021.
  10. ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 340. ISBN 978-0857114105.
  11. ^ "Fycompa Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 17 January 2021. Retrieved 27 October 2021.
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