User:Mr. Ibrahem/Pegaptanib

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Pegaptanib sodium
Clinical data
Trade namesMacugen
AHFS/Drugs.comMonograph
MedlinePlusa607057
Routes of
administration		Intravitreal injection
Drug classVascular endothelial growth factor (VEGF) inhibitor[1]
Legal status
Legal status
Pharmacokinetic data
Elimination half-life10 days
Identifiers
  • RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2'-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'→3')-dT), 5'-ester with α,α'-[4,12-dioxo-6[[[5-(phosphoonoxy)pentyl]amino]carbonyl]-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl]bis[ω-methoxypoly(oxy-1,2-ethanediyl)], sodium salt[2]
Chemical and physical data
FormulaC294H342F13N107Na28O188P28[C2H4O](m+n) (m+n≈900)
Molar mass~50 kg/mol
  (verify)

Pegaptanib, sold under the brand name Macugen, is a medication that was used to treat wet age-related macular degeneration (AMD).[3] It was used by injection into the eye.[3]

Common side effects include blurry vision, cataracts, conjunctival bleeding, eye pain, and increased intraocular pressure.[1] Other side effects may include anaphylaxis and endophthalmitis.[1] It works by blocking vascular endothelial growth factor (VEGF).[1]

Pegaptanib was approved for medical use in the United States in 2004.[4] While it was approved in Europe in 2006, this approval was subsequently withdrawn.[5] In the United States a vial of 0.3 mg costs about 780 USD.[6] As of 2016 it is no longer available in the USA.[7]

References[edit]

  1. ^ a b c d e f "Pegaptanib Monograph for Professionals". Drugs.com. Archived from the original on 3 June 2021. Retrieved 26 October 2021.
  2. ^ Drug Information: Pegaptanib Sodium Injection Archived 2013-12-14 at the Wayback Machine
  3. ^ a b c "Macugen (pegaptanib)" (PDF). European Medicines Agency: 1–3. 2010. Archived (PDF) from the original on 2013-12-13. Retrieved 2013-12-08.
  4. ^ "MACUGEN- pegaptanib sodium injection, solution". dailymed.nlm.nih.gov. Archived from the original on 26 October 2021. Retrieved 26 October 2021.
  5. ^ "Macugen". Archived from the original on 6 May 2021. Retrieved 26 October 2021.
  6. ^ "Macugen Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 30 September 2020. Retrieved 26 October 2021.
  7. ^ Wong, Randall (2016). "Ocular drug delivery systems" (PDF). Retina Today. Archived (PDF) from the original on 26 October 2021. Retrieved 26 October 2021.
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