User:Mr. Ibrahem/Olodaterol

Mr. Ibrahem/Olodaterol
Clinical data
Pronunciation	Striverdi Respimat /ˈstrɪvərdi ˈrɛspɪmæt/ STRIV-ər-dee RES-pim-at
Trade names	Striverdi Respimat
AHFS/Drugs.com	Monograph
Pregnancy; category	AU: B3; ;
Routes of; administration	Inhalation (MDI)
Drug class	LABA
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	~30% (inhalation)
Protein binding	~60%
Metabolism	Liver
Elimination half-life	7.5 hours
Excretion	Feces (53%), urine (38%) — following IV administration
Identifiers
	IUPAC name 6-hydroxy-8-{(1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl}-4H-1,4-benzoxazin-3-one;
Chemical and physical data
Formula	C21H26N2O5
Molar mass	386.448 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)(CC1=CC=C(C=C1)OC)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O;
	InChI InChI=1S/C21H26N2O5/c1-21(2,10-13-4-6-15(27-3)7-5-13)22-11-18(25)16-8-14(24)9-17-20(16)28-12-19(26)23-17/h4-9,18,22,24-25H,10-12H2,1-3H3,(H,23,26)/t18-/m0/s1; Key:COUYJEVMBVSIHV-SFHVURJKSA-N;

Olodaterol, sold under the brand name Striverdi, is a long-acting β adrenoreceptor agonist (LABA) used to treat chronic obstructive pulmonary disease (COPD).^[1] Use is not recommended in asthma.^[1] It is breathed into the lungs.^[1]

Common side effects include cough, diarrhea, joint pain, rash, and runny nose.^[1] Other side effects may include QT prolongation and bronchospasm.^[1] In asthma there are concerns regarding an increased risk of death.^[1] While there is no evidence of harm in pregnancy, such use has not been well studied.^[3]

Olodaterol was approved for medical use in the United States in 2014.^[1] It is also available in combination with tiotropium as a single inhaler.^[1] In the United Kingdom a month of medication costs the NHS about £26 as of 2021.^[4] In the United States this amount costs about 230 USD.^[5]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l "Olodaterol Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 7 November 2021.
^ "Striverdi Respimat (olodaterol) Inhalation Spray For Oral Inhalation. U.S. Full Prescribing Information" (PDF). Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877 USA. Archived (PDF) from the original on 5 March 2016. Retrieved 23 February 2016.
^ "Olodaterol (Striverdi Respimat) Use During Pregnancy". Drugs.com. Archived from the original on 5 December 2020. Retrieved 7 November 2021.
^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 268. ISBN 978-0857114105.
^ "Striverdi Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 15 July 2016. Retrieved 7 November 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l "Olodaterol Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 7 November 2021.

[PI-2] "Striverdi Respimat (olodaterol) Inhalation Spray For Oral Inhalation. U.S. Full Prescribing Information" (PDF). Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877 USA. Archived (PDF) from the original on 5 March 2016. Retrieved 23 February 2016.

[3] "Olodaterol (Striverdi Respimat) Use During Pregnancy". Drugs.com. Archived from the original on 5 December 2020. Retrieved 7 November 2021.

[BNF81-4] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 268. ISBN 978-0857114105.

[5] "Striverdi Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 15 July 2016. Retrieved 7 November 2021.

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