User:Mr. Ibrahem/Nizatidine

Mr. Ibrahem/Nizatidine
Clinical data
Trade names	Axid, Tazac, others
AHFS/Drugs.com	Monograph
MedlinePlus	a694030
License data	US DailyMed: Nizatidine; US FDA: Nizatidine;
Pregnancy; category	AU: B3; ;
Routes of; administration	By mouth
Drug class	H2 antagonist
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: OTC / Rx-only;
Pharmacokinetic data
Bioavailability	>70%
Protein binding	35%
Metabolism	Liver
Elimination half-life	1–2 hours
Excretion	Kidney
Identifiers
	IUPAC name (E)-1-N'-[2-[[2-[(dimethylamino)methyl]-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;
Chemical and physical data
Formula	C12H21N5O2S2
Molar mass	331.45 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [O-][N+](=O)\C=C(/NC)NCCSCc1nc(sc1)CN(C)C;
	InChI InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3/b11-6+ ; Key:SGXXNSQHWDMGGP-IZZDOVSWSA-N ;
	(what is this?) (verify)

Nizatidine, sold under the brand name Axid, is a medication used to treat stomach ulcers and gastroesophageal reflux disease.^[1] It may be take for 4 to 12 weeks.^[2] It is taken by mouth.^[1]

Common side effects include headache and dizziness.^[1] Other side effects may include pneumonia.^[1] No harm has been found in pregnancy, but such use has not been well studied.^[3] Use when breastfeeding appears safe.^[2] It is a histamine H₂ receptor antagonist that inhibits stomach acid production.^[1]

Nizatidine was patented in 1980 and approved for medical use in 1987.^[4] It was approved in the United States in 1988.^[1] It is available as a generic medication and over the counter.^[2] In the United Kingdom a month of medication costs the NHS about £18 as of 2021.^[2] In the United States this costs about 20 USD.^[5]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Nizatidine Monograph for Professionals". Drugs.com. Archived from the original on 7 August 2020. Retrieved 13 November 2021.
^ ^a ^b ^c ^d BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 81. ISBN 978-0857114105.
^ "Nizatidine Use During Pregnancy". Drugs.com. Archived from the original on 26 October 2020. Retrieved 13 November 2021.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 44. ISBN 9783527607495. Archived from the original on 2020-07-29. Retrieved 2021-02-13.
^ "Nizatidine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 13 November 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Nizatidine Monograph for Professionals". Drugs.com. Archived from the original on 7 August 2020. Retrieved 13 November 2021.

[BNF81-2] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 81. ISBN 978-0857114105.

[3] "Nizatidine Use During Pregnancy". Drugs.com. Archived from the original on 26 October 2020. Retrieved 13 November 2021.

[4] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 44. ISBN 9783527607495. Archived from the original on 2020-07-29. Retrieved 2021-02-13.

[5] "Nizatidine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 13 November 2021.

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