User:Mr. Ibrahem/Netilmicin

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Mr. Ibrahem/Netilmicin
Clinical data
Trade namesNetromycin, others
Other names1-N-ethylsisomicin
Routes of
administration		Eye drop, by injection
Drug classAminoglycoside[1]
Legal status
Legal status
  • UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability~0%
Elimination half-life2.5 hours
Identifiers
  • (2R,3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4-Amino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-6-(ethylamino)-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol
Chemical and physical data
FormulaC21H41N5O7
Molar mass475.587 g·mol−1
3D model (JSmol)
  • O[C@]3(C)[C@H](NC)[C@@H](O)[C@@H](O[C@H]2[C@H](NCC)C[C@H](N)[C@@H](OC1O\C(=C/CC1N)CN)[C@@H]2O)OC3
  • InChI=1S/C21H41N5O7/c1-4-26-13-7-12(24)16(32-19-11(23)6-5-10(8-22)31-19)14(27)17(13)33-20-15(28)18(25-3)21(2,29)9-30-20/h5,11-20,25-29H,4,6-9,22-24H2,1-3H3/t11?,12-,13+,14-,15+,16+,17-,18+,19?,20+,21-/m0/s1 checkY
  • Key:CIDUJQMULVCIBT-KALHTFJLSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Netilmicin, sold under the brand name Netromycin among others, is an antibiotic used to treat conjunctivitis and urinary tract infections among other bacterial infections.[2][3][5] It is available as an eye drop, and has been given by injection.[4][5]

Side effects may include eye redness or discomfort.[4] Other concerns include hearing problems and kidney problems.[4][5] Use is not recommended when breastfeeding.[5] It is an aminoglycoside and works by interfering with protein production by bacteria.[5][1]

Netilmicin was patented in 1973 and approved for medical use in 1981.[6] It was approved for external eye infections in the UK in 2019.[1] The eye drop is on the World Health Organization's List of Essential Medicines as an alternative to gentamicin.[7] In the United Kingdom a course of treatment costs the [[NHS about £10.[8] It is made by altering sisomicin.[5]

References[edit]

  1. ^ a b c "Netilmicin". SPS - Specialist Pharmacy Service. 2 June 2020. Archived from the original on 24 October 2021. Retrieved 21 August 2020.
  2. ^ a b "eEML - Electronic Essential Medicines List". list.essentialmeds.org. Archived from the original on 9 June 2023. Retrieved 9 September 2023.
  3. ^ a b "Netilmicin - brand name list from Drugs.com". Drugs.com. Archived from the original on 6 June 2023. Retrieved 9 September 2023.
  4. ^ a b c d e "Netilmicin". NICE. BNF. Archived from the original on 10 September 2023. Retrieved 9 September 2023.
  5. ^ a b c d e f g Campoli-Richards, DM; Chaplin, S; Sayce, RH; Goa, KL (November 1989). "Netilmicin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use". Drugs. 38 (5): 703–56. doi:10.2165/00003495-198938050-00003. PMID 2689137.
  6. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 508. ISBN 9783527607495. Archived from the original on 2023-08-26. Retrieved 2023-03-08.
  7. ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  8. ^ "Netilmicin Medicinal forms". NICE. BNF. Archived from the original on 10 September 2023. Retrieved 9 September 2023.
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