User:Mr. Ibrahem/Nafcillin
Clinical data | |
---|---|
Other names | Nafcillin sodium |
AHFS/Drugs.com | Monograph |
MedlinePlus | a685019 |
Routes of administration | IM, IV |
Drug class | Antibiotic (penicillin)[1] |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Protein binding | 90% |
Metabolism | <30% liver |
Elimination half-life | 0.5 hours |
Excretion | Biliary and kidney |
Identifiers | |
| |
Chemical and physical data | |
Formula | C21H22N2O5S |
Molar mass | 414.48 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Nafcillin, sold under the brand name Unipen among others, is an antibiotic used to treat and prevent straphylococcal infections.[1] This includes includes of the skin, respiratory tract, urine, and blood.[1] It is not effective against MRSA.[1] It is given by injection into a vein or muscle.[1]
Common side effects include pain and inflammation at the site of injection.[1] Other side effects may include anaphylaxis and Clostridioides difficile infection.[1] There is no evidence of harm with use in pregnancy, though such use has not been well studied.[2] It is a beta-lactam antibiotic of the penicillin type.[1] It is penicillinase resistant.[1]
Nafcillin was approved for medical use in the United States in 1965.[1] In the United States 10 doses of 2 grams costs about 90 USD as of 2021.[3] In 2012, out of 38 countries it was only available in one.[4]
References[edit]
- ^ a b c d e f g h i j k l "Nafcillin Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 11 November 2021.
- ^ "Nafcillin Use During Pregnancy". Drugs.com. Archived from the original on 4 December 2020. Retrieved 11 November 2021.
- ^ "Nafcillin Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 27 September 2017. Retrieved 11 November 2021.
- ^ Pulcini, Céline; Bush, Karen; Craig, William A.; Frimodt-Møller, Niels; Grayson, M. Lindsay; Mouton, Johan W.; Turnidge, John; Harbarth, Stephan; Gyssens, Inge C. (15 January 2012). "Forgotten Antibiotics: An Inventory in Europe, the United States, Canada, and Australia". Clinical Infectious Diseases. 54 (2): 268–274. doi:10.1093/cid/cir838.