User:Mr. Ibrahem/Mupirocin
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 Pseudomonic acid A (PA-A), the principal component of mupirocin | |
| Clinical data | |
|---|---|
| Trade names | Bactroban, others |
| Other names | Muciprocin[1] |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a688004 |
| License data | |
| Pregnancy category |
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| Routes of administration | Topical |
| Drug class | Carboxylic acid |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Protein binding | 97% |
| Elimination half-life | 20 to 40 minutes |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C26H44O9 |
| Molar mass | 500.629 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 77 to 78 °C (171 to 172 °F) |
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  (what is this?) (verify) | |
Mupirocin, sold under the brand name Bactroban among others, is a topical antibiotic useful against superficial skin infections such as impetigo or folliculitis.[3][5] It may also be used to get rid of methicillin-resistant S. aureus (MRSA) when present in the nose without symptoms.[3] Due to concerns of developing resistance, use for greater than ten days is not recommended.[5] It is used as a cream or ointment applied to the skin.[3]
Common side effects include itchiness and rash at the site of application, headache, and nausea.[3] Long term use may result in increased growth of fungi.[3] Use during pregnancy and breastfeeding appears to be safe.[3] Mupirocin is in the carboxylic acid class of medications.[6] It works by blocking a bacteria's ability to make protein, which usually results in bacterial death.[3]
Mupirocin was initially isolated in 1971 from Pseudomonas fluorescens.[7] It is on the World Health Organization's List of Essential Medicines.[8] The wholesale cost in the developing world is about US$2.10 for a 15 g tube.[9] In the United States, a course of treatment costs $25 to $50.[10] In 2017, it was the 186th most commonly prescribed medication in the United States, with more than three million prescriptions.[11][12]
References[edit]
- ^ Fleischer, Alan B. (2002). Emergency Dermatology: A Rapid Treatment Guide. McGraw Hill Professional. p. 173. ISBN 9780071379953. Archived from the original on 2017-09-10.
- ^ "Drug Product Database Online Query". health-products.canada.ca. Archived from the original on 30 July 2019. Retrieved 30 July 2019.
- ^ a b c d e f g h i "Mupirocin". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
- ^ "Single Drug Information – International Medical Products Price Guide". mshpriceguide. Archived from the original on 6 March 2021. Retrieved 16 August 2020.
- ^ a b World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 298. hdl:10665/44053. ISBN 9789241547659.
- ^ Khanna, Ramesh; Krediet, Raymond T. (2009). Nolph and Gokal's Textbook of Peritoneal Dialysis (3 ed.). Springer Science & Business Media. p. 421. ISBN 9780387789408. Archived from the original on 2017-09-10.
- ^ Heggers, John P.; Robson, Martin C.; Phillips, Linda G. (1990). Quantitative Bacteriology: Its Role in the Armamentarium of the Surgeon. CRC Press. p. 118. ISBN 9780849351297. Archived from the original on 2017-09-10.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ "Mupirocin". International Drug Price Indicator Guide. Archived from the original on 22 January 2018. Retrieved 8 December 2016.
- ^ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 178. ISBN 9781284057560.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
- ^ "Mupirocin - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.