User:Mr. Ibrahem/Mitoxantrone

Mr. Ibrahem/Mitoxantrone
Clinical data
Trade names	Novantrone, Onkotrone, others
Other names	Mitozantrone
AHFS/Drugs.com	Monograph
MedlinePlus	a608019
Routes of; administration	Mainly intravenous
Drug class	Antineoplastic (anthracenedione)
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	n/a
Protein binding	78%
Metabolism	Liver (CYP2E1)
Elimination half-life	75 hours
Excretion	Kidney
Identifiers
	IUPAC name 1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino); ethylamino]-anthracene-9,10-dione;
Chemical and physical data
Formula	C22H28N4O6
Molar mass	444.488 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2c1c(c(NCCNCCO)ccc1NCCNCCO)C(=O)c3c2c(O)ccc3O;
	InChI InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2 ; Key:KKZJGLLVHKMTCM-UHFFFAOYSA-N ;
	(verify)

Mitoxantrone, also known as mitozantrone, is a medication used to treat cancer and multiple sclerosis.^[1]^[2] Types of cancer it is used for include acute myeloid leukemia, prostate cancer, breast cancer, and non-Hodgkin's lymphoma.^[1]^[2] It is given by gradual injection into a vein.^[1]

Common side effects include nausea, diarrhea, hair loss, infection, fever, swelling, and shortness of breath.^[1] Other side effects may include tumor lysis syndrome, neuropathy, bone marrow suppression, and heart damage.^[1] Use in pregnancy may harm the baby.^[1] It is an anthracenedione antineoplastic agent.^[1]

Mitoxantrone was approved for medical use in the United States in 1987.^[1] It is available as a generic medication.^[2] In the United Kingdom it costs the NHS about £51 per 20 mg vial as of 2021.^[2] This amount in the United States costs about 180 USD.^[3]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "MitoXANTRONE Monograph for Professionals". Drugs.com. Archived from the original on 7 May 2021. Retrieved 18 November 2021.
^ ^a ^b ^c ^d BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 948. ISBN 978-0857114105.
^ "Mitoxantrone Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 19 April 2021. Retrieved 18 November 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "MitoXANTRONE Monograph for Professionals". Drugs.com. Archived from the original on 7 May 2021. Retrieved 18 November 2021.

[BNF81-2] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 948. ISBN 978-0857114105.

[3] "Mitoxantrone Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 19 April 2021. Retrieved 18 November 2021.

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