User:Mr. Ibrahem/Maprotiline

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Mr. Ibrahem/Maprotiline
Clinical data
Trade namesLudiomil, Maprolu, others
Other namesMaprotiline hydrochloride; maprotiline methanesulfonate; Ba 34276[1][2][3]
AHFS/Drugs.comMonograph
MedlinePlusa682158
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth, intramuscular, intravenous
Drug classTetracyclic antidepressant (TeCA)[4]
Legal status
Legal status
Pharmacokinetic data
Bioavailability66–70%
Protein binding88%
MetabolismLiver
Onset of action6 hours
Elimination half-life27–58 hours
ExcretionUrine (57%) and bile (30%) as glucuronides, 3–4% as unchanged drug
Identifiers
  • N-Methyl-9,10-ethanoanthracene-9(10H)-propanamine
Chemical and physical data
FormulaC20H23N
Molar mass277.411 g·mol−1
3D model (JSmol)
  • CNCCC[C@@]12C3=CC=CC=C3[C@@H](C4=CC=CC=C14)CC2
  • InChI=1S/C20H23N/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20/h2-5,7-10,15,21H,6,11-14H2,1H3/t15-,20+ ☒N
  • Key:QSLMDECMDJKHMQ-GSXCWMCISA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Maprotiline, sold under the brand name Ludiomil among others, is a medication used to treat depression, anxiety, and bipolar disorder.[4] It is taken by mouth.[4]

Common side effects include dry mouth, constipation, sleepiness, dizziness, and anxiety.[4] Other side effects may include suicide, rash, seizures, bipolar, and arrhythmias.[4] While there is no clear harm from us in pregnancy, such use has not been well studied.[5] It is a tetracyclic antidepressant (TeCA).[4]

Maprotiline was approved for medical use in the United States in 1980.[4] In the United States 100 tablets of 75 mg costs about 175 USD as of 2021.[6] It is available is various countries globally.[2]

References[edit]

  1. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 752–. ISBN 978-1-4757-2085-3.
  2. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 630–. ISBN 978-3-88763-075-1.
  3. ^ "Maprotiline - Drugs.com". drugs.com. Archived from the original on 16 August 2017. Retrieved 28 March 2018.
  4. ^ a b c d e f g h i j "Maprotiline Monograph for Professionals". Drugs.com. Archived from the original on 19 January 2021. Retrieved 14 November 2021.
  5. ^ "Maprotiline (Ludiomil) Use During Pregnancy". Drugs.com. Archived from the original on 5 December 2020. Retrieved 14 November 2021.
  6. ^ "Maprotiline Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 10 August 2020. Retrieved 14 November 2021.
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