User:Mr. Ibrahem/Liothyronine
Clinical data | |
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Trade names | Cytomel, Tertroxin, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682462 |
License data |
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Routes of administration | By mouth, intravenous |
Legal status | |
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Pharmacokinetic data | |
Protein binding | 99.7% |
Elimination half-life | 2.5 days |
Identifiers | |
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Chemical and physical data | |
Formula | C15H11I3NNaO4 |
Molar mass | 672.959 g·mol−1 |
3D model (JSmol) | |
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Liothyronine is a manufactured form of the thyroid hormone triiodothyronine (T3).[1] It is most commonly used to treat hypothyroidism and myxedema coma.[1] It is generally less preferred than levothyroxine.[1] It can be taken by mouth or by injection into a vein.[1]
Side effects may occur from excessive doses.[1] This may include weight loss, fever, headache, anxiety, trouble sleeping, arrythmias, and heart failure.[1] Use in pregnancy and breastfeeding is generally safe.[3][1] Regular blood tests are recommended to verify the appropriateness of the dose being taken.[1]
Liothyronine was approved for medical use in 1956.[1] It is available as a generic medication.[3] A month's supply in the United Kingdom costs the NHS about £247 as of 2019.[3] In the United States the wholesale cost of this amount is about US$22.40.[4] In 2017, it was the 252nd most commonly prescribed medication in the United States, with more than one million prescriptions.[5][6]
References[edit]
- ^ a b c d e f g h i j k "Liothyronine Sodium Monograph for Professionals". Drugs.com. Archived from the original on 27 February 2019. Retrieved 27 February 2019.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 24 September 2020. Retrieved 8 September 2020.
- ^ a b c British National Formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 757. ISBN 9780857113382.
- ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
- ^ "Liothyronine Sodium - Drug Usage Statistics". ClinCalc. Archived from the original on 29 November 2020. Retrieved 11 April 2020.