User:Mr. Ibrahem/Lifitegrast

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Mr. Ibrahem/Lifitegrast
Clinical data
PronunciationXiidra /ˈzaɪdrə/[1]
Trade namesXiidra
Other namesSAR-1118
AHFS/Drugs.comMonograph
MedlinePlusa616039
Pregnancy
category
  • AU: B1
Routes of
administration		Eye drops
Legal status
Legal status
Identifiers
  • N-{[2-(1-Benzofuran-6-ylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl}-3-(methylsulfonyl)-L-phenylalanine
Chemical and physical data
FormulaC29H24Cl2N2O7S
Molar mass615.48 g·mol−1
3D model (JSmol)
  • CS(=O)(=O)c1cccc(c1)C[C@@H](C(=O)O)NC(=O)c2c(cc3c(c2Cl)CCN(C3)C(=O)c4ccc5ccoc5c4)Cl
  • InChI=1S/C29H24Cl2N2O7S/c1-41(38,39)20-4-2-3-16(11-20)12-23(29(36)37)32-27(34)25-22(30)13-19-15-33(9-7-21(19)26(25)31)28(35)18-6-5-17-8-10-40-24(17)14-18/h2-6,8,10-11,13-14,23H,7,9,12,15H2,1H3,(H,32,34)(H,36,37)/t23-/m0/s1
  • Key:JFOZKMSJYSPYLN-QHCPKHFHSA-N

Lifitegrast, sold under the brand name Xiidra, is a medication used to treat dry eyes.[2] It is unclear if its benefits are greater than its harms.[3][4] It is used as eye drops.[2]

Common side effects include blurry vision, red eyes, headache, change in taste, and itchiness.[2] Safety in pregnancy is not clear.[5] It reduces inflammation by inhibiting T cells.[3]

Lifitegrast was approved for medical use in the United States in 2016.[2] It is not approved in either the United Kingdom or Europe.[3][4] In the United States it costs about 580 USD per month as of 2021.[6]

References[edit]

  1. ^ "Patient information: Xiidra® (ZYE-druh) (lifitegrast ophthalmic solution) 5% for topical ophthalmic use" (PDF). Novartis. June 2020. Archived (PDF) from the original on 2021-02-13. Retrieved 2021-02-05.
  2. ^ a b c d e f "Lifitegrast Monograph for Professionals". Drugs.com. Archived from the original on 5 March 2021. Retrieved 22 November 2021.
  3. ^ a b c "Lifitegrast". SPS - Specialist Pharmacy Service. 8 February 2016. Archived from the original on 11 December 2021. Retrieved 23 November 2021.
  4. ^ a b "Xiidra: Withdrawal of the marketing authorisation application". Archived from the original on 14 November 2021. Retrieved 23 November 2021.
  5. ^ "Lifitegrast ophthalmic (Xiidra) Use During Pregnancy". Drugs.com. Archived from the original on 28 November 2020. Retrieved 23 November 2021.
  6. ^ "Lifitegrast Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 28 October 2016. Retrieved 23 November 2021.
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