User:Mr. Ibrahem/Levorphanol

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Mr. Ibrahem/Levorphanol
Structural formula
Ball-and-stick model
Clinical data
Trade namesLevo-Dromoran
Other namesRo 1-5431[1]
AHFS/Drugs.comMonograph
MedlinePlusa682020
Routes of
administration		By mouth
Drug classOpioid
Legal status
Legal status
Pharmacokinetic data
Bioavailability70% (by mouth); 100% (IV)
Protein binding40%
MetabolismLiver
Onset of actionWith 1 hr[2]
Elimination half-life11–16 hours
Duration of actionUp to 8 hrs[3]
Identifiers
  • (1R,9R,10R)-17-Methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol
Chemical and physical data
FormulaC17H23NO
Molar mass257.377 g·mol−1
3D model (JSmol)
  • CN1CC[C@]23CCCC[C@H]2[C@H]1Cc4c3cc(O)cc4
  • InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1 checkY
  • Key:JAQUASYNZVUNQP-USXIJHARSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Levorphanol, sold under the brand name Levo-Dromoran, is an opioid medication used to treat moderate to severe pain.[3] It is taken by mouth.[3] Maximum effects occur within an hour and last up to 8 hours.[2][3]

Common side effects include nausea, flushing, urinary retention, itchiness, and constipation.[3] Other side effects may include insufficient breathing (respiratory depression), abuse, serotonin syndrome, and low blood pressure.[3] Safety in pregnancy is unclear.[4]

Levorphanol was first described in Germany in 1946.[5] It has been in medical use in the United States since 1953.[6] In the United States 90 tablets of 2 mg cost about 1,100 USD as of 2021.[7] In the United States it is a Schedule II controlled substance.[3]

References[edit]

  1. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 656–. ISBN 978-1-4757-2085-3.
  2. ^ a b Hogans, Beth B.; Barreveld, Antje M. (7 November 2019). Pain Care Essentials. Oxford University Press. p. PT164. ISBN 978-0-19-009142-2. Archived from the original on 11 December 2021. Retrieved 22 November 2021.
  3. ^ a b c d e f g h i j "Levorphanol Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 22 November 2021.
  4. ^ "Levorphanol (Levo-Dromoran) Use During Pregnancy". Drugs.com. Archived from the original on 28 November 2020. Retrieved 22 November 2021.
  5. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 527. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2021-10-21.
  6. ^ Gudin J, Fudin J, Nalamachu S (January 2016). "Levorphanol Use: Past, Present and Future". Postgraduate Medicine. 128 (1): 46–53. doi:10.1080/00325481.2016.1128308. PMID 26635068. S2CID 3912175.
  7. ^ "Levorphanol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 22 November 2021.
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