User:Mr. Ibrahem/Indometacin

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Mr. Ibrahem/Indometacin
Clinical data
Pronunciation/ɪndoʊˈmɛtəsɪn/
Trade namesIndocid, Indocin, others
Other namesIndomethacin (USAN US)
AHFS/Drugs.comMonograph
License data
Pregnancy
category
Routes of
administration		By mouth, rectal, IV, topical
Drug classNSAID[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability~100% (oral), 80–90% (rectal)
Protein binding99%[2]
MetabolismLiver
Elimination half-life2.6-11.2 hours (adults), 12-28 hours (babies)[2]
ExcretionKidney (60%), fecal (33%)
Identifiers
  • 2-{1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid
Chemical and physical data
FormulaC19H16ClNO4
Molar mass357.79 g·mol−1
3D model (JSmol)
  • Cc1c(c2cc(ccc2n1C(=O)c3ccc(cc3)Cl)OC)CC(=O)O
  • InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23) checkY
  • Key:CGIGDMFJXJATDK-UHFFFAOYSA-N checkY
  (verify)

Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) primarily used for pain and inflammation.[3] This may include painful periods, gout, arthritis, and pericarditis.[3][1] Other uses include to close a patent ductus arteriosus is a premature baby.[1] It may be used by mouth, in the rectum, or by injection.[1]

Common side effects include, nausea, heart burn, and dizziness.[1] Severe side effects may include cardiovascular disease, gastrointestinal bleeding, hair failure, kidney injury, and allergic reactions.[1] Use is not recommended during the last third of pregnancy.[3] Indometacin works by decreasing the production of prostaglandin by the enzyme cyclooxygenase.[1]

Indometacin was patented in 1961 and approved for medical use in 1963.[4][5] It is available as a generic medication and marketed under a number of trade names.[6][3] As of 2015 the cost for a typical month of medication in the United States is less than 25 USD.[7] In the United Kingdom this amount costs the NHS less than 5 pounds as of 2020.[3] In 2017, it was the 291st most commonly prescribed medication in the United States, with more than one million prescriptions.[8][9]

References[edit]

  1. ^ a b c d e f g "Indomethacin Monograph for Professionals". Drugs.com. Retrieved 8 October 2020.
  2. ^ a b Brayfield A, ed. (14 January 2014). "Indometacin". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Retrieved 22 June 2014.
  3. ^ a b c d e BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 1180. ISBN 9780857113658.
  4. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 517. ISBN 9783527607495. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  5. ^ Hart FD, Boardman PL (October 1963). "Indomethacin: A New Non-steroid Anti-inflammatory Agent". British Medical Journal. 2 (5363): 965–70. doi:10.1136/bmj.2.5363.965. PMC 1873102. PMID 14056924.
  6. ^ "Indomethacin". go.drugbank.com. Retrieved 8 October 2020.
  7. ^ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 8. ISBN 9781284057560. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  8. ^ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
  9. ^ "Indomethacin - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.
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