User:Mr. Ibrahem/Indinavir

Mr. Ibrahem/Indinavir
Clinical data
Trade names	Crixivan
Other names	Indinavir sulfate
AHFS/Drugs.com	Monograph
MedlinePlus	a696028
License data	EU EMA: by INN; US FDA: Indinavir;
Routes of; administration	By mouth
Drug class	Protease inhibitor
Pharmacokinetic data
Bioavailability	~65%
Protein binding	60%
Metabolism	Liver via CYP3A4
Elimination half-life	1.8 ± 0.4 hours
Identifiers
	IUPAC name (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}butyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide;
Chemical and physical data
Formula	C36H47N5O4
Molar mass	613.803 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)(C)NC(=O)[C@@H]1CN(CCN1C[C@H](C[C@@H](Cc2ccccc2)C(=O)N[C@H]3c4ccccc4C[C@H]3O)O)Cc5cccnc5;
	InChI InChI=1S/C36H47N5O4/c1-36(2,3)39-35(45)31-24-40(22-26-12-9-15-37-21-26)16-17-41(31)23-29(42)19-28(18-25-10-5-4-6-11-25)34(44)38-33-30-14-8-7-13-27(30)20-32(33)43/h4-15,21,28-29,31-33,42-43H,16-20,22-24H2,1-3H3,(H,38,44)(H,39,45)/t28-,29+,31+,32-,33+/m1/s1 ; Key:CBVCZFGXHXORBI-PXQQMZJSSA-N ;
	(what is this?) (verify)

Indinavir (IDV), sold under the brand name Crixivan, is a medication used to treat HIV/AIDS together with other medications.^[1] It is not a first line treatment.^[1] It is taken by mouth.^[1]

Common side effects include nausea, abdominal pain, headache, and kidney stones.^[1] Other side effects may include liver problems, diabetes, and body fat redistribution.^[1] Safety in pregnancy is unclear.^[2] It is a protease inhibitor.^[1]

Indinavir was patented in 1991 and approved for medical use in the United States and Europe in 1996.^[3]^[1]^[4] In the United States it costs about 450 USD per month as of 2021.^[5]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Indinavir Monograph for Professionals". Drugs.com. Archived from the original on 24 August 2021. Retrieved 26 November 2021.
^ "Indinavir (Crixivan) Use During Pregnancy". Drugs.com. Archived from the original on 28 November 2020. Retrieved 26 November 2021.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 509. ISBN 9783527607495. Archived from the original on 2021-06-20. Retrieved 2021-08-05.
^ "Crixivan". Archived from the original on 15 April 2021. Retrieved 26 November 2021.
^ "Indinavir Sulfate Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 26 November 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Indinavir Monograph for Professionals". Drugs.com. Archived from the original on 24 August 2021. Retrieved 26 November 2021.

[2] "Indinavir (Crixivan) Use During Pregnancy". Drugs.com. Archived from the original on 28 November 2020. Retrieved 26 November 2021.

[Fis2006-3] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 509. ISBN 9783527607495. Archived from the original on 2021-06-20. Retrieved 2021-08-05.

[EPAR2021-4] "Crixivan". Archived from the original on 15 April 2021. Retrieved 26 November 2021.

[5] "Indinavir Sulfate Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 26 November 2021.

[1]

[2]

[3]

[4]

[5]