User:Mr. Ibrahem/Fosphenytoin

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Mr. Ibrahem/Fosphenytoin
Clinical data
Trade namesCerebyx, others
Other namesFosphenytoin sodium[1]
AHFS/Drugs.comMonograph
MedlinePlusa604036
License data
Routes of
administration		Intravenous, intramuscular
Drug classAnticonvulsant
Legal status
Legal status
  • US: ℞-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability100% (IM)
Protein binding95–99%
MetabolismLiver
Elimination half-life15 minutes to convert to phenytoin
ExcretionKidney (as phenytoin)
Identifiers
  • (2,5-Dioxo-4,4-diphenyl-imidazolidin-1-yl)methoxyphosphonic acid
Chemical and physical data
FormulaC16H15N2O6P
Molar mass362.278 g·mol−1
3D model (JSmol)
  • O=C3N(C(=O)C(c1ccccc1)(c2ccccc2)N3)COP(=O)(O)O
  • InChI=1S/C16H15N2O6P/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23/h1-10H,11H2,(H,17,20)(H2,21,22,23) checkY
  • Key:XWLUWCNOOVRFPX-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Fosphenytoin, sold under the brand name Cerebyx among others, is a medication used to treat status epilepticus and prevent seizures.[1] It may be used instead of phenytoin in those who cannot take medication by mouth.[1] It is given by injection into a vein or muscle.[1]

Common side effects include dizziness, nystagmus, itchiness, numbness, sleepiness, and poor coordination.[2] Other side effects may include low blood pressure, QT prolongation, Stevens-Johnson syndrome, angioedema, and liver problems.[2] Use in pregnancy may harm the baby.[3] It is a prodrug of phenytoin and works by blocking sodium channels.[1][2]

Fosphenytoin was approved for medical use in the United States in 1996.[2] It is available as a generic medication.[2] In the United Kingdom a 750 mg vial costs the NHS about £40.[1] In the United States this amount costs about 24 USD.[4]

References[edit]

  1. ^ a b c d e f g BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 332. ISBN 978-0857114105.
  2. ^ a b c d e f "Fosphenytoin Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 13 December 2021.
  3. ^ "Fosphenytoin Use During Pregnancy". Drugs.com. Archived from the original on 24 November 2020. Retrieved 13 December 2021.
  4. ^ "Fosphenytoin Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 11 April 2021. Retrieved 13 December 2021.
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