User:Mr. Ibrahem/Fosamprenavir

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Mr. Ibrahem/Fosamprenavir
Clinical data
Trade namesLexiva, Telzir
AHFS/Drugs.comMonograph
MedlinePlusa604012
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth
Drug classProtease inhibitor[1]
Legal status
Legal status
Pharmacokinetic data
BioavailabilityUnknown
Protein binding90%
MetabolismHydrolysed to amprenavir and phosphate in GI tract epithelium
Elimination half-life7.7 hours
ExcretionFecal (as metabolites of amprenavir)
Identifiers
  • {[(2R,3S)-1-[N-(2-methylpropyl)(4-aminobenzene)sulfonamido]-3-({[(3S)-oxolan-3-yloxy]carbonyl}amino)-4-phenylbutan-2-yl]oxy}phosphonic acid
Chemical and physical data
FormulaC25H36N3O9PS
Molar mass585.608 g/mol
623.700 g/mol (calcium salt) g·mol−1
3D model (JSmol)
  • O=C(O[C@H]1CCOC1)N[C@@H](Cc2ccccc2)[C@H](OP(=O)(O)O)CN(CC(C)C)S(=O)(=O)c3ccc(N)cc3
  • InChI=1S/C25H36N3O9PS/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32)/t21-,23-,24+/m0/s1 checkY
  • Key:MLBVMOWEQCZNCC-OEMFJLHTSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Fosamprenavir, sold under the brand name Lexiva and Telzir, is a medication used to treat and prevent HIV/AIDS.[1] It is used together with other medications, including typically a low amount of ritonavir.[1][2] It is taken by mouth.[1]

Common side effects include diarrhea, vomiting, headache, and rash.[1] Other side effects may include Stevens-Johnson syndrome, sulfonamide allergy, high blood sugar, immune reconstitution syndrome, abnormal lipids, and kidney stones.[1] While it has been used in pregnancy, safety is unclear.[3] It is a protease inhibitor and pro-drug of amprenavir.[1][2]

Fosamprenavir was approved for medical use in the United States in 2003 and Europe in 2004.[1][4] It is available as a generic medication.[5] In the United Kingdom a month of medication costs the NHS about £260 as of 2021.[2] In the United States this amount costs about 300 USD.[5]

References[edit]

  1. ^ a b c d e f g h i j "Fosamprenavir Monograph for Professionals". Drugs.com. Archived from the original on 28 June 2021. Retrieved 13 December 2021.
  2. ^ a b c d BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 697. ISBN 978-0857114105.
  3. ^ "Fosamprenavir Use During Pregnancy". Drugs.com. Archived from the original on 27 June 2021. Retrieved 13 December 2021.
  4. ^ "Telzir". Archived from the original on 15 May 2021. Retrieved 13 December 2021.
  5. ^ a b "Fosamprenavir Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 13 December 2021.
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