User:Mr. Ibrahem/Fludarabine
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| Clinical data | |
|---|---|
| Trade names | Fludara, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a692003 |
| Pregnancy category |
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| Routes of administration | intravenous, by mouth |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 55% |
| Protein binding | 19 to 29% |
| Elimination half-life | 20 hours |
| Excretion | kidney |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C10H13FN5O7P |
| Molar mass | 365.214 g·mol−1 |
| 3D model (JSmol) | |
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  (what is this?) (verify) | |
Fludarabine, sold under the brand name Fludara among others, is a chemotherapy medication used in the treatment of leukemia and lymphoma.[2] These include chronic lymphocytic leukemia, non-Hodgkin's lymphoma, acute myeloid leukemia, and acute lymphocytic leukemia.[2] It is given by injection into a vein or by mouth.[2][3]
Common side effects include nausea, diarrhea, fever, rash, shortness of breath, numbness, vision changes, and feeling tired.[2] Severe side effects include brain dysfunction, low blood cell counts, and lung inflammation.[2] Use in pregnancy will likely result in harm to the baby.[2] Fludarabine is in the purine analog family of medications and works by interfering with the duplication of DNA.[2][4]
Fludarabine was approved for medical use in the United States in 1991.[2] It is on the World Health Organization's List of Essential Medicines.[5] The wholesale cost in the developing world is about US$54.00 per 50 mg vial.[6] In the United Kingdom it costs about 155.00 pounds per 50 mg vial.[3]
References[edit]
- ^ Cite error: The named reference
who1was invoked but never defined (see the help page). - ^ a b c d e f g h "Fludarabine Phosphate". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
- ^ a b British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 590. ISBN 9780857111562.
- ^ Helms, Richard A.; Quan, David J. (2006). Textbook of Therapeutics: Drug and Disease Management. Lippincott Williams & Wilkins. p. 2309. ISBN 9780781757348. Archived from the original on 2016-12-20.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ "Fludarabine Phosphate". International Drug Price Indicator Guide. Retrieved 8 December 2016.