User:Mr. Ibrahem/Entacapone

Mr. Ibrahem/Entacapone
Clinical data
Pronunciation	/ˌɛntəkəˈpoʊn/ or /ɛnˈtækəpoʊn/
Trade names	Comtan, Comtess, others
AHFS/Drugs.com	Monograph
MedlinePlus	a601236
License data	EU EMA: by INN; US DailyMed: Entacapone;
Pregnancy; category	AU: B3; ;
Routes of; administration	By mouth
Drug class	COMT inhibitors
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	35%
Protein binding	98% (binds to serum albumin)
Metabolism	Liver
Elimination half-life	0.4–0.7 hours
Excretion	Feces (90%), urine (10%)
Identifiers
	IUPAC name (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide;
Chemical and physical data
Formula	C14H15N3O5
Molar mass	305.290 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [O-][N+](=O)c1cc(\C=C(/C#N)C(=O)N(CC)CC)cc(O)c1O;
	InChI InChI=1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5+ ; Key:JRURYQJSLYLRLN-BJMVGYQFSA-N ;
	(verify)

Entacapone, sold under the brand name Comtan among others, is a medication used to treat Parkinson's disease.^[1] It is used to prevent the wearing off of levodopa/carbidopa before the next dose is due.^[1] It is taken by mouth.^[3]

Common side effects include uncontrollable movements, nausea, and change in urine color.^[2] Other side effects may include abdominal pain, urge to gamble, falling asleep, prostate cancer, low blood pressure with standing, and hallucinations.^[1] It works by blocking the enzyme that breaks down levodopa, catechol-O-methyltransferase (COMT).^[2]

Entacapone was approved for medical use in Europe in 1998 and the United States in 1999.^[1]^[2] It is available as a generic medication.^[3] In the United Kingdom 100 tablets of 200 mg costs the NHS about £16 as of 2021.^[3] This amount in the United States costs about 40 USD.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f "Entacapone Monograph for Professionals". Drugs.com. Archived from the original on 8 May 2021. Retrieved 15 December 2021.
^ ^a ^b ^c ^d "Comtess". Archived from the original on 12 November 2020. Retrieved 15 December 2021.
^ ^a ^b ^c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 433. ISBN 978-0857114105.
^ "Entacapone Prices and Entacapone Coupons - GoodRx". GoodRx. Retrieved 15 December 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f "Entacapone Monograph for Professionals". Drugs.com. Archived from the original on 8 May 2021. Retrieved 15 December 2021.

[EPAR2021-2] "Comtess". Archived from the original on 12 November 2020. Retrieved 15 December 2021.

[BNF81-3] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 433. ISBN 978-0857114105.

[4] "Entacapone Prices and Entacapone Coupons - GoodRx". GoodRx. Retrieved 15 December 2021.

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