User:Mr. Ibrahem/Doravirine

Mr. Ibrahem/Doravirine
Clinical data
Trade names	Pifeltro
Other names	MK-1439
AHFS/Drugs.com	Monograph
MedlinePlus	a618048
License data	US DailyMed: Doravirine;
Routes of; administration	By mouth
Drug class	Non-nucleoside reverse transcriptase inhibitor (NNRTI)
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only; EU: Rx-only;
Identifiers
	IUPAC name 3-Chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydro-3-pyridinyl}oxy)benzonitrile;
Chemical and physical data
Formula	C17H11ClF3N5O3
Molar mass	425.75 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cn1c(n[nH]c1=O)Cn2ccc(c(c2=O)Oc3cc(cc(c3)Cl)C#N)C(F)(F)F;
	InChI InChI=1S/C17H11ClF3N5O3/c1-25-13(23-24-16(25)28)8-26-3-2-12(17(19,20)21)14(15(26)27)29-11-5-9(7-22)4-10(18)6-11/h2-6H,8H2,1H3,(H,24,28); Key:ZIAOVIPSKUPPQW-UHFFFAOYSA-N;

Doravirine, sold under the brand name Pifeltro, is a medication used to treat HIV/AIDS.^[1] It is taken together with other HIV medicines.^[1] It is taken by mouth, generally once per day.^[1]

Common side effects include nausea, dizziness, headache, tiredness, diarrhea, and abnormal dreams.^[1] Other side effects may include immune reconstitution syndrome.^[1] Safety in pregnancy is unclear.^[4] It is a non-nucleoside reverse transcriptase inhibitor (NNRTI).^[1]

Doravirine was approved for medical use in the United States and Europe in 2018.^[3] In the United Kingdom a month of medication costs the NHS about £470 as of 2021.^[5] This amount in the United States is about 1,500 USD.^[6] It is also available as the combination doravirine/lamivudine/tenofovir.^[5]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Pifeltro- doravirine tablet, film coated". DailyMed. 10 October 2019. Archived from the original on 28 October 2020. Retrieved 22 September 2020.
^ "Pifeltro 100 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 26 September 2020. Retrieved 1 October 2020.
^ ^a ^b ^c "Pifeltro EPAR". European Medicines Agency (EMA). Archived from the original on 28 October 2020. Retrieved 1 October 2020.
^ "Doravirine (Pifeltro) Use During Pregnancy". Drugs.com. Archived from the original on 3 December 2020. Retrieved 27 December 2021.
^ ^a ^b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 683. ISBN 978-0857114105.
^ "Pifeltro Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 27 December 2021.

[PI2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Pifeltro- doravirine tablet, film coated". DailyMed. 10 October 2019. Archived from the original on 28 October 2020. Retrieved 22 September 2020.

[2] "Pifeltro 100 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 26 September 2020. Retrieved 1 October 2020.

[EPAR2021-3] "Pifeltro EPAR". European Medicines Agency (EMA). Archived from the original on 28 October 2020. Retrieved 1 October 2020.

[4] "Doravirine (Pifeltro) Use During Pregnancy". Drugs.com. Archived from the original on 3 December 2020. Retrieved 27 December 2021.

[BNF81-5] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 683. ISBN 978-0857114105.

[6] "Pifeltro Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 27 December 2021.

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