User:Mr. Ibrahem/Didanosine
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| Clinical data | |
|---|---|
| Pronunciation | dye dan' oh seen[1] |
| Trade names | Videx |
| Other names | 2′,3′-dideoxyinosine |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a691006 |
| Pregnancy category |
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| Routes of administration | By mouth |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 30 to 54% |
| Protein binding | Less than 5% |
| Elimination half-life | 1.5 hours |
| Excretion | Kidney |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C10H12N4O3 |
| Molar mass | 236.231 g·mol−1 |
| 3D model (JSmol) | |
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| (verify) | |
Didanosine (ddI), sold under the brand name Videx, is a medication used to treat HIV/AIDS.[2] It is taken with other HIV medication.[2] It is not a first line treatment.[3] It is taken by mouth.[2]
Common side effects include diarrhea, peripheral neuropathy, nausea, headache, and rash.[1] Other side effects may include pancreatitis, liver problems, lactic acidosis, and optic neuritis.[1] Other medications are generally preferred in pregnancy.[3] It is a nucleoside reverse-transcriptase inhibitor (NRTI).[2]
Didanosine was first described in 1975 and approved for use in the United States in 1991.[4] In the United States 30 tablets of 400 mg costs about 270 USD as of 2021.[5] While previously commonly used, it is now rarely used due to better tolerated medicine.[6]
References[edit]
- ^ a b c d "DailyMed - DIDANOSINE capsule, delayed release pellets". dailymed.nlm.nih.gov. Archived from the original on 11 January 2022. Retrieved 24 December 2021.
- ^ a b c d "Didanosine Monograph for Professionals". Drugs.com. Archived from the original on 20 November 2021. Retrieved 24 December 2021.
- ^ a b "Didanosine Use During Pregnancy". Drugs.com. Archived from the original on 20 November 2021. Retrieved 24 December 2021.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 505. ISBN 9783527607495. Archived from the original on 2021-02-07. Retrieved 2021-04-27.
- ^ "Didanosine Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 23 January 2021. Retrieved 24 December 2021.
- ^ "Didanosine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 11 January 2022. Retrieved 24 December 2021.