User:Mr. Ibrahem/Certolizumab pegol
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 Syringe with 200mg certolizumab pegol | |
| Monoclonal antibody | |
|---|---|
| Type | Fab' fragment |
| Source | Humanized (from mouse) |
| Target | TNF alpha |
| Clinical data | |
| Trade names | Cimzia |
| Other names | CDP870 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a608041 |
| License data |
|
| Pregnancy category |
|
| Routes of administration | Subcutaneous |
| Drug class | TNF inhibitor[1] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Elimination half-life | about 11 days |
| Excretion | Kidney (PEG only) |
| Chemical and physical data | |
| Formula | C2115H3252N556O673S16 |
| Molar mass | 47749.46 g·mol−1 |
  (what is this?) (verify) | |
Certolizumab pegol, sold under the brand name Cimzia, is a medication used to treat Crohn's disease, rheumatoid arthritis, psoriatic arthritis, plaque psoriasis, and ankylosing spondylitis.[1] It is given by injection under the skin.[3]
Common side effects include infections such as abscesses, low white blood cells, nausea, headache, numbness, high blood pressure, liver inflammation, rash, and pain at the site of injection.[2] Other side effects may include cancer, heart failure, and angioedema.[3] It is a fragment of a monoclonal antibody that binds to tumor necrosis factor alpha (TNF-α).[3]
Certolizumab pegol was approved for medical use in the United States in 2008 and Europe in 2009.[1][2] It is on the World Health Organization's List of Essential Medicines as an alternative to adalimumab.[4] In the United Kingdom 400 mg costs the NHS about £715 as of 2021.[5] This amount in the United States costs about 4,700 USD.[6]
References[edit]
- ^ a b c d "Cimzia- certolizumab pegol kit Cimzia- certolizumab pegol injection, solution". DailyMed. 24 April 2020. Archived from the original on 19 July 2020. Retrieved 18 July 2020.
- ^ a b c "Cimzia". Archived from the original on 30 December 2021. Retrieved 3 January 2022.
- ^ a b c "Certolizumab Monograph for Professionals". Drugs.com. Retrieved 3 January 2022. Cite error: The named reference "AHFS2022" was defined multiple times with different content (see the help page).
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1159. ISBN 978-0857114105.
- ^ "Cimzia Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 3 January 2022.