User:Mr. Ibrahem/Butenafine

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Mr. Ibrahem/Butenafine
Clinical data
Trade namesMentax, Lotrimin Ultra, others
Other namesButenafine hydrochloride
AHFS/Drugs.comMonograph
Routes of
administration
Topical (cream)
Drug classAntifungal[1]
Legal status
Legal status
  • OTC (Lotrimin Ultra), ℞-only (Mentax)
Pharmacokinetic data
MetabolismLiver
Elimination half-life35–100 hours
Identifiers
  • [(4-tert-butylphenyl)methyl](methyl)(naphthalen-1-ylmethyl)amine
Chemical and physical data
FormulaC23H27N
Molar mass317.47 g·mol−1
3D model (JSmol)
  • N(C)(Cc1ccc(cc1)C(C)(C)C)Cc3c2ccccc2ccc3
  • InChI=1S/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3 checkY
  • Key:ABJKWBDEJIDSJZ-UHFFFAOYSA-N checkY
  (verify)

Butenafine, sold under the brand names Mentax among others, is an antifungal used to treat ringworm and pityriasis versicolor.[1] It is applied to the skin.[1]

Common side effects include itchiness, and stinging.[1] Other side effects may include allergic reactions.[1] There is no evidence of harm in pregnancy; however, such use has not been well studied.[3] It is a benzylamine, which is similar to allylamines, such as terbinafine.[1] It is believed to work by affecting the cell membrane.[1]

Butenafine was approved for medical use in the United States in 1996.[1] It is available over the counter.[4] In the United States a 30 gram tube costs about 20 USD as of 2022.[4]

References[edit]

  1. ^ a b c d e f g h i j "Butenafine Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 12 January 2022.
  2. ^ Mylan Pharmaceuticals Inc. "Mentax (butenafine hydrochloride) Cream. Human Prescription Drug Label". dailymed.nlm.nih.gov. National Institutes of Health, U.S. National Library of Medicine, Health & Human Services. Archived from the original on 28 August 2016. Retrieved 24 August 2016.
  3. ^ "Butenafine topical Use During Pregnancy". Drugs.com. Archived from the original on 26 November 2020. Retrieved 12 January 2022.
  4. ^ a b "Butenafine topical Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 12 January 2022.