User:Mr. Ibrahem/Bimatoprost

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Mr. Ibrahem/Bimatoprost
Clinical data
Trade namesLumigan, Latisse, others
AHFS/Drugs.comMonograph
MedlinePlusa602030
License data
Pregnancy
category
Routes of
administration		Topical (eye drops)
Drug classProstaglandin analog[2]
Legal status
Legal status
Pharmacokinetic data
BioavailabilityLow
Protein binding88%
Onset of action4 hrs
Elimination half-life45 min after IV application
Duration of action≥ 24 hrs
Excretion67% kidney, 25% fecal
Identifiers
  • 7-[3,5-dihydroxy-2- (3-hydroxy-5-phenyl-pent-1-enyl)- cyclopentyl]-N-ethyl-hept-5-enamide
Chemical and physical data
FormulaC25H37NO4
Molar mass415.574 g·mol−1
3D model (JSmol)
  • CCNC(=O)CCCC=CCC1C(CC(C1C=CC(CCC2=CC=CC=C2)O)O)O
  • InChI=1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1 checkY
  • Key:AQOKCDNYWBIDND-FTOWTWDKSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Bimatoprost, sold under the trade name Lumigan among others, is a medication used to treat high pressure inside the eye including glaucoma.[2] Specifically it is used for open angle glaucoma when other agents are not sufficient.[2][4] It may also be used to increase the size of the eyelashes.[6][3] It is used as an eye drop and effects generally occur within four hours.[2][3]

Common side effects include red eyes, dry eyes, change in color of the eyes, blurry vision, and cataracts.[2][3][4] Use during pregnancy or breastfeeding is generally not recommended.[1][3][4] It is a prostaglandin analog and works by increasing the outflow of aqueous fluid from the eyes.[2]

Bimatoprost was approved for medical use in the United States in 2001.[2] It is available as a generic medication.[7][6][4] A 3 milliliter bottle in the United Kingdom costs the NHS about £9.30 as of 2019.[4] In the United States the wholesale cost of this amount is about US$80.[8] In 2017, it was the 231st most commonly prescribed medication in the United States, with more than two million prescriptions.[9][10]

References[edit]

  1. ^ a b c "Bimatoprost ophthalmic (Lumigan) Use During Pregnancy". Drugs.com. 14 October 2019. Archived from the original on 21 June 2019. Retrieved 4 January 2020.
  2. ^ a b c d e f g h i "Bimatoprost Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 27 March 2019. Retrieved 26 March 2019.
  3. ^ a b c d e "Lumigan- bimatoprost solution/ drops". DailyMed. 31 July 2017. Archived from the original on 21 September 2020. Retrieved 4 January 2020.
  4. ^ a b c d e f British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1149. ISBN 9780857113382.
  5. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 20 September 2020. Retrieved 9 September 2020.
  6. ^ a b "Bimatoprost solution/ drops". DailyMed. 18 September 2019. Archived from the original on 21 September 2020. Retrieved 4 January 2020.
  7. ^ "Bimatoprost". Drugs.com. 2 December 2019. Archived from the original on 7 March 2016. Retrieved 4 January 2020.
  8. ^ "NADAC as of 2019-02-27". Centers for Medicare & Medicaid Services (CMS). Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  9. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  10. ^ "Bimatoprost - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.
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