User:Mr. Ibrahem/Argatroban

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Mr. Ibrahem/Argatroban
Clinical data
AHFS/Drugs.comMonograph
License data
Routes of
administration		Intravenous
Drug classDirect thrombin inhibitor[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability100% (intravenous)
Protein binding54%
Metabolismhepatic
Elimination half-life39 and 51 minutes
Identifiers
  • (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-
    [[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]
    sulfonylamino]pentanoyl]-4-methyl-piperidine-2-
    carboxylic acid
Chemical and physical data
FormulaC23H36N6O5S
Molar mass508.64 g·mol−1
3D model (JSmol)
  • O=C(O)[C@@H]3N(C(=O)C(NS(=O)(=O)c1cccc2c1NCC(C2)C)CCC/N=C(\N)N)CC[C@@H](C)C3
  • InChI=1S/C23H36N6O5S/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26)/t14-,15?,17+,18-/m1/s1 ☒N
  • Key:KXNPVXPOPUZYGB-IOVMHBDKSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Argatroban is a medication used to prevent and treat blood clots in people who have heparin-induced thrombocytopenia (HIT).[1][3] It may also be used in people undergoing percutaneous coronary intervention (PCI) with HIT.[3] It is given by gradual injection into a vein.[1]

Common side effects include low blood pressure, fever, diarrhea, shortness of breath, and headache.[3] Other side effects may include bleeding.[3] It should not be used in people with severe liver problems.[3] Safety in pregnancy is unclear.[3] It is an anticoagulant, specifically a direct thrombin inhibitor.[1][4]

Argatroban was approved for medical use in the United States in 2000.[3] It is available as a generic medication.[1] In the United Kingdom 50 mg costs about £50 as of 2021.[1] This amount in the United States is about 110 USD.[5]

References[edit]

  1. ^ a b c d e f g BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 147. ISBN 978-0857114105.
  2. ^ "Argatroban injection, solution". DailyMed. Archived from the original on 10 June 2021. Retrieved 10 June 2021.
  3. ^ a b c d e f g h i "DailyMed - ARGATROBAN injection". dailymed.nlm.nih.gov. Archived from the original on 16 January 2022. Retrieved 16 January 2022.
  4. ^ Di Nisio M, Middeldorp S, Buller HR (2005). "Direct thrombin inhibitors". N Engl J Med. 353 (10): 1028–40. doi:10.1056/NEJMra044440. PMID 16148288. Archived from the original on 2021-11-05. Retrieved 2021-06-13.
  5. ^ "Argatroban Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 22 January 2021. Retrieved 16 January 2022.
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