User:Mr. Ibrahem/Alemtuzumab
 | |
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized (from rat) |
| Target | CD52 |
| Clinical data | |
| Trade names | Campath, Mabcampath, Lemtrada, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a608053 |
| License data |
|
| Pregnancy category |
|
| Routes of administration | Intravenous infusion |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Elimination half-life | ~288 hrs |
| Chemical and physical data | |
| Formula | C6468H10066N1732O2005S40 |
| Molar mass | 145454.20 g·mol−1 |
  (what is this?) (verify) | |
Alemtuzumab, sold under the brand names Campath and Lemtrada among others, is a medication used to treat chronic lymphocytic leukemia (CLL) and multiple sclerosis.[1] In CLL, it has been used as both a first line and second line treatment.[1] In MS it is generally only recommended if other treatments have not worked.[1] It is given by injection into a vein or under the skin.[1]
Common side effects include low blood cells, infusion reactions, infection, nausea, diarrhea, and trouble sleeping.[2] People taking the medication should not get live vaccines.[2] Use in pregnancy may harm the baby.[2] It is a monoclonal antibody that binds to CD52, a protein present on lymphocytes, resulting in their destruction.[3]
Alemtuzumab was approved for medical use in the United States and Europe in 2001.[1][4] The brand approved for CLL in Europe; however, was withdrawn while a new brand was approved for MS.[4][3] In the United Kingdom a via of 12 mg costs the NHS about £7,000 as of 2021.[5] This amount in the United States is about 27,700 USD.[6]
References[edit]
- ^ a b c d e f "Alemtuzumab Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 January 2012. Retrieved 15 July 2019.
- ^ a b c d "DailyMed - CAMPATH- alemtuzumab injection". dailymed.nlm.nih.gov. Archived from the original on 25 March 2021. Retrieved 13 January 2022.
- ^ a b "Lemtrada". Archived from the original on 29 June 2021. Retrieved 13 January 2022.
- ^ a b "MabCampath". Archived from the original on 14 January 2022. Retrieved 13 January 2022.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 904. ISBN 978-0857114105.
- ^ "Lemtrada Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 21 January 2021. Retrieved 13 January 2022.