User:JeanOhm/CASP

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This is Jean's CASP page

CASP[edit]

Model of tethering involving CASP.[1]

Tne CUX1 gene Alternatively Spliced Product was first reported in 1997.[2][a] The CUX1 gene has up to 33 exons. CASP mRNA includes exons 1 through 14 and 25 through 33.[4] The human CASP protein is predicted to contain 678 amino acids, of which 400 are shared with CUTL1.[2] CASP protein is approximately 80 kD.[2] It lacks the DNA binding region of CUTL1,[2][5] but instead contains a trans-membrane domain that allows it to insert into lipid bilayers.[5] It has been localized to the Golgi apparatus.[5]

CASP has been reported to be part of a complex with Golgin 84 that tethers COPI vesicles and is important for retrograde transport in the Golgi and between the Golgi and endoplasmic reticulum.[6] The targeting of vesicles involves tethers and SNAREs.[6]

Interactions[edit]

Cux1 (CUTL1, CDP, CDP/Cux) has been shown to interact with:

Notes[edit]

  1. ^ This CASP is not the same as the scaffolding protein called CASP[3] for Cytohesin/ARNO ... Scaffolding Protein

References[edit]

  1. ^ Sohda M, Misumi Y, Yamamoto A, Nakamura N, Ogata S, Sakisaka S, Hirose S, Ikehara Y, Oda K (2010). "Interaction of Golgin-84 with the COG complex mediates the intra-Golgi retrograde transport". Traffic (Copenhagen, Denmark). 11 (12): 1552–66. doi:10.1111/j.1600-0854.2010.01123.x. PMID 20874812.
  2. ^ a b c d Lievens PM, Tufarelli C, Donady JJ, Stagg A, Neufeld EJ (1997). "CASP, a novel, highly conserved alternative-splicing product of the CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains, and interacts with full-length CDP in vitro". Gene. 197 (1–2): 73–81. PMID 9332351.
  3. ^ Mansour M, Lee SY, Pohajdak B (2002). "The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP". The Journal of Biological Chemistry. 277 (35): 32302–9. doi:10.1074/jbc.M202898200. PMID 12052827.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  4. ^ Ramdzan ZM, Nepveu A (2014). "CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers". Nature Reviews. Cancer. 14 (10): 673–82. doi:10.1038/nrc3805. PMID 25190083.
  5. ^ a b c Gillingham AK, Pfeifer AC, Munro S (2002). "CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin". Molecular Biology of the Cell. 13 (11): 3761–74. doi:10.1091/mbc.E02-06-0349. PMC 133590. PMID 12429822.
  6. ^ a b Malsam J, Satoh A, Pelletier L, Warren G (2005). "Golgin tethers define subpopulations of COPI vesicles". Science (New York, N.Y.). 307 (5712): 1095–8. doi:10.1126/science.1108061. PMID 15718469.
  7. ^ Li S, Aufiero B, Schiltz RL, Walsh MJ (June 2000). "Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7166–71. doi:10.1073/pnas.130028697. PMC 16517. PMID 10852958.
  8. ^ Gupta S, Luong MX, Bleuming SA, Miele A, Luong M, Young D, Knudsen ES, Van Wijnen AJ, Stein JL, Stein GS (September 2003). "Tumor suppressor pRB functions as a co-repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled histone H4 transcription". J. Cell. Physiol. 196 (3): 541–56. doi:10.1002/jcp.10335. PMID 12891711.
  9. ^ Liu J, Barnett A, Neufeld EJ, Dudley JP (July 1999). "Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation". Mol. Cell. Biol. 19 (7): 4918–26. doi:10.1128/mcb.19.7.4918. PMC 84297. PMID 10373541.
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