User:Dmarelius/sandbox

This is the user sandbox of Dmarelius. A user sandbox is a subpage of the user's user page. It serves as a testing spot and page development space for the user and is not an encyclopedia article. Create or edit your own sandbox here.

Other sandboxes: Main sandbox | Template sandbox

Finished writing a draft article? Are you ready to request review of it by an experienced editor for possible inclusion in Wikipedia? Submit your draft for review!

The biosynthesis of atropine starting from L-Phenylalanine first undergoes a transamination forming phenylpyruvic acid which is then reduced to phenyl-lactic acid ^[1]. Coenzyme A then couples phenyl-lactic acid with tropine forming littorine, which then undergoes a radical rearrangement initiated with a P450 enzyme forming hyoscyamine aldehyde^[2]. A dehydrogenase then reduces the aldehyde to a primary alcohol making (-)-hyoscamine, which upon racemization forms atropine^[3].

^ Dewick, Paul M. (2009). Medicinal natural products : A biosynthetic approach (3rd ed.). Chichester: A John Wiley & Sons. ISBN 978-0470741672
^ Dewick, Paul M. (2009). Medicinal natural products : A biosynthetic approach (3rd ed.). Chichester: A John Wiley & Sons. ISBN 978-0470741672
^ Dewick, Paul M. (2009). Medicinal natural products : A biosynthetic approach (3rd ed.). Chichester: A John Wiley & Sons. ISBN 978-0470741672

[1] Dewick, Paul M. (2009). Medicinal natural products : A biosynthetic approach (3rd ed.). Chichester: A John Wiley & Sons. ISBN 978-0470741672

[2] Dewick, Paul M. (2009). Medicinal natural products : A biosynthetic approach (3rd ed.). Chichester: A John Wiley & Sons. ISBN 978-0470741672

[3] Dewick, Paul M. (2009). Medicinal natural products : A biosynthetic approach (3rd ed.). Chichester: A John Wiley & Sons. ISBN 978-0470741672

[1]

[2]

[3]