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Takayasu arteritis
Left anterior oblique angiographic image of Takayasu's arteritis showing areas of stenosis in multiple great vessels.
Specialty	Immunology, rheumatology

Takayasu arteritis also reffered to as Martorell syndrome, occlusive thromboaortopathy, pulseless disease, aortic arch syndrome, idiopathic aortitis, aortoarteritis, and stenosing aortitis is a large-vessel, idiopathic, granulomatous arteritis that primarily affects the aorta, major branch arteries, and, less frequently, the pulmonary arteries.

Depending on where the disease is in its progression, Takayasu arteritis can present with a variety of clinical symptoms. Non-specific systemic symptoms predominate for weeks or months during the early, actively inflammatory phase, but they are often disregarded or mistaken for signs of more common, acute illnesses. The illness typically manifests in the second or third decade of life.

Although the exact cause of Takayasu arteritis is still unknown, evidence of a genetic component to the disease's pathogenesis is primarily provided by the condition's association with the HLA complex.

Blood vessel imaging is necessary for the diagnosis and ongoing treatment of Takayasu's arteritis. Angiography is the preferred method of diagnosis.

The goal of treating Takayasu's arteritis is to reduce vascular inflammation and shield organs from permanent harm. For the best chance of a positive result, early diagnosis and prompt, intensive treatment are crucial.

Signs and symptoms

The majority of patients have hypertension, and the following general features are most common at the beginning of the disease, headaches (31%) musculoskeletal symptoms (myalgia, arthralgia, or arthritis; 14%), fever (29%), dyspnea (23%), weight loss (22%), and vomiting (20%).