Talk:SNP array

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Sentence issue[edit]

"As SNPs are highly conserved throughout evolution and within a population..."- an incorrect sentence. SNPs are not highly conserved, most SNPs fall outside coding sequences and outside regulatory regions, most SNPs are in nonfunctional DNA and evolving neutrally, only a small minority of SNPs are under selection. Also it makes little sense to say "SNPs are highly conserved throughout evolution" because SNPs are by definition intra-species variation (that's what a polymorphism is). If a SNP was "highly conserved" then it would be the same nucleotide in every individual of a species and across multiple species, but then it would no longer be classified as a SNP as it would be fixed in the population/species. The 2nd half of the sentence, "the map of SNPs serves as an excellent genotypic marker for research", has no clear meaning. I suggest the whole sentence is removed. -End of rant- — Preceding unsigned comment added by 131.111.176.16 (talk) 10:51, 4 February 2015 (UTC)[reply]

Probes <-> Targets[edit]

I think that probe and target are mixed up in the explanation (Section: Principles). Aren't the probes (SNP detection oligos) fixed to the array, and the and the target sequences (i.e. the fragmented and labled genome) are washed over? This would be supported by the picture of the DNA_microarray article.

134.99.165.175 (talk) 10:17, 4 November 2011 (UTC)[reply]

I agree that this is backwards, and will fix it. Mkkuhner (talk) 21:18, 2 February 2015 (UTC)[reply]

Pronunciation question[edit]

Do you say "S-N-P" or "snip"? — Preceding unsigned comment added by 92.213.30.142 (talk) 19:40, 20 May 2014 (UTC)[reply]

Researchers in the field say "snip." Mkkuhner (talk) 21:18, 2 February 2015 (UTC)[reply]