Talk:Muscimol

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Structure 8[edit]

Structure 8 in the synthesis is wrong, it should be a chloromethylisoxazole, not a dichloroacetylamidomethyl-isoxazole. You mixed up two different synthesis routes here. The Dichloroacetamide was an intermediate in another synthesis route by the same author. 2001:9E8:32E2:2300:DD0D:3CCA:CA9:3E59 (talk) 14:03, 26 February 2023 (UTC)[reply]

Toxicity[edit]

Article writes "Human deaths are rare, mainly occurring in young children, the elderly, or those with serious chronic illnesses."

But this is pointless since it obviously refers to mushroom poisoning, not poisoning with muscimol. The sentence implies that many people have experienced muscimol poisoning when in fact the number of people to ever have ingested pure muscimol will be quite low and no fatal case is presumably known.

Poisoning with mushrooms is complex and cannot be limited to muscimol action. In any case it should be discussed in the relevant mushroom articles, not here. 2001:9E8:32E2:2300:DD0D:3CCA:CA9:3E59 (talk) 14:15, 26 February 2023 (UTC)[reply]

Pharmacology[edit]

In the pharmacology section, the dosage information is incorrect. I noticed there has been much back and forth in regards to what to list with respect to mg of active ingredient vs. g of carrier fungus. From a biochemical perspective, this would be easily resolved by stating "dosage of 10-15 mg of muscimol, which is present in 5-10 g of fresh mushroom... Author recommends 8.5 mg of muscimol, which is stated to be present in as little as 1 g of dried mushroom." etc. This adds clarity between the subject chemical dosage and the carrier food/fungus amount to be injested, and given that the subject of the article is the chemical itself, would provide better insight into dosing, whether the fungus is the carrier or otherwise. 2603:900A:1AF0:93D0:8A9:8721:58D9:40BE (talk) 20:41, 2 October 2023 (UTC)[reply]