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The Empire at its greatest extent under Justinian in 550

The Byzantine Empire (or Byzantium) was the Eastern Roman Empire during the periods of Late Antiquity and the Middle Ages, centred on the capital of Constantinople. Known simply as the "Roman Empire" (Greek: Βασιλεία Ῥωμαίων, Basileia Rhōmaiōn) or Romania (Ῥωμανία) to its inhabitants and neighbours, it was the direct continuation of the Ancient Roman State and maintained Roman state traditions. Byzantium is today distinguished from ancient Rome proper insofar as it was oriented towards Greek culture, characterised by Christianity rather than Roman paganism and was predominantly Greek-speaking rather than Latin-speaking.

The Byzantine Empire existed for more than a thousand years, from its genesis in the 4th century to 1453. During most of its existence, it remained one of the most powerful economic, cultural, and military forces in Europe, despite setbacks and territorial losses, especially during the Arab–Byzantine wars. The Empire recovered during the Macedonian dynasty, rising again to become a preeminent power in the Eastern Mediterranean by the late 10th century, rivalling the Fatimid Caliphate.

After 1071, however, much of Asia Minor, the Empire's heartland, was lost to the Seljuq Turks. The Komnenian restoration regained some ground and briefly reestablished dominance in the 12th century, but following the death of Emperor Andronikos I Komnenos (r. 1183–85) and the end of the Komnenos dynasty in the late 12th century the Empire declined again. The Empire received a mortal blow in 1204 from the Fourth Crusade, when it was dissolved and divided into competing Byzantine Greek and Latin realms.

Successive civil wars in the 14th century further sapped the Empire's strength, and most of its remaining territories were lost in the Byzantine–Ottoman Wars, which culminated in the Fall of Constantinople and the conquest of remaining territories by the Ottoman Empire in the 15th century.