Draft:Никитоны метаболизм

Никитоны метаболизм
	Дээд талд: Төвлөрсөн никотины шингэн Зүүн доод талд: никотины молекулын араг ясны дүрслэл Баруун доод талд: никотины молекулын бөмбөлөг хэлбэртэй загвар
Clinical data
Trade names	Никоретте, Никотрол
AHFS/Drugs.com	Monograph
Pregnancy; category	AU: D; ;
Dependence; liability	Physical: low–moderate; Psychological: moderate–high
Addiction; liability	Very high
Routes of; administration	Inhalation; insufflation; oral – buccal, sublingual, and ingestion; transdermal; rectal
ATC code	N07BA01 (WHO) QP53AX13 (WHO);
Legal status
Legal status	AU: S7 (Dangerous drug); BR: Unscheduled; CA: Unscheduled; DE: Unscheduled; NZ: Unscheduled; UK: General sales list (GSL, OTC); US: OTC and prescription; UN: Unscheduled; EU: Unscheduled; In general: Legal for recreational use in some form in all countries, except Bhutan;
Pharmacokinetic data
Protein binding	<5%
Metabolism	Primarily hepatic: CYP2A6, CYP2B6, FMO3, others
Metabolites	Cotinine
Elimination half-life	1-2 hours; 20 hours active metabolite
Excretion	Renal, urine pH-dependent;; 10–20% (gum), 30% (inhaled); 10–30% (intranasal)
Identifiers
	IUPAC name 3-[(2S)-1-метилпирролидин-2-ил]пиридин;
CAS Number	54-11-5 ;
PubChem CID	89594;
IUPHAR/BPS	2585;
DrugBank	DB00184 ;
ChemSpider	80863 ;
UNII	6M3C89ZY6R;
KEGG	D03365 ;
ChEBI	CHEBI:18723 ;
ChEMBL	ChEMBL3 ;
PDB ligand	NCT (PDBe, RCSB PDB);
Chemical and physical data
Formula	C10H14N2
Molar mass	162.236 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Chiral
Density	1.01 g/cm3
Melting point	−79 °C (−110 °F)
Boiling point	247 °C (477 °F)
	SMILES c1ncccc1[C@@H]2CCCN2C;
	InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 ; Key:SNICXCGAKADSCV-JTQLQIEISA-N ;

Submission declined on 27 November 2023 by Aviram7 (talk).

The submission appears to be written in Mangolian. This is the English language Wikipedia; we can only accept articles written in the English language. Please provide a high-quality English language translation of your submission. Have you visited the Wikipedia home page? You can probably find a version of Wikipedia in your language.

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Declined by Aviram7 5 months ago. Last edited by Aviram7 5 months ago. Reviewer: Inform author.

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Comment: Submission language is Mangolian. ~~ αvírαm|(tαlk) 04:01, 27 November 2023 (UTC)

Никотины метаболизм гэдэг нь тамхины донтуулагч бодис болох никотиныг бие махбодид задалж, гадагшлуулах үйл явц юм. Никотин нь элгэнд метаболизмд ордог бөгөөд энэ нь олон тооны идэвхгүй метаболит болж хувирдаг. Никотины хамгийн чухал метаболит нь котинин бөгөөд зүрхний цохилт, цусны даралтыг нэмэгдүүлдэг никотиноос 10 дахин илүү хүчтэй байдаг.

Никотин нь харьцангуй хурдан метаболизмд ордог бөгөөд тунгийн тал нь 2 цагийн дотор биеэс гадагшилдаг. Гэсэн хэдий ч никотины солилцооны хурд нь нас, хүйс, жин, элэгний үйл ажиллагаа зэрэг олон хүчин зүйлээс хамаарч өөр өөр байж болно. Удаан хугацаанд тамхи татдаг тамхичид тамхи татдаггүй хүмүүсээс илүү удаан никотины метаболизмд ордог.

Никотины задралын бүтээгдэхүүн нь биеэс шээс, ялгадасаар гадагшилдаг.

Никотины солилцооны үндсэн үе шатуудыг нэгтгэн харуулсан хүснэгт:

Step	Description
1. Никотин уушигнаас эсвэл арьсаар дамжин цусанд ордог.
2. Никотин нь элгэнд дамждаг.
3. Никотин нь элгэнд олон тооны идэвхгүй метаболит болж хувирдаг бөгөөд тэдгээрийн хамгийн чухал нь котинин юм.
4. Никотины задралын бүтээгдэхүүн нь биеэс шээс, ялгадасаар гадагшилдаг.

Никотины солилцооны хурд нь цусан дахь никотины түвшинд нөлөөлж, улмаар никотины донтолтын хүнд байдалд нөлөөлдөг. Никотиныг илүү удаан метаболизмд оруулдаг хүмүүс никотиныг хурдан метаболизмд оруулдаг хүмүүстэй харьцуулахад никотинд донтох магадлал өндөр байдаг.

References[edit]

^ Cite error: The named reference Dependence-withdrawal was invoked but never defined (see the help page).
^ Cosci F, Pistelli F, Lazzarini N, Carrozzi L (2011). "Nicotine dependence and psychological distress: outcomes and clinical implications in smoking cessation". Psychology Research and Behavior Management. 4: 119–28. doi:10.2147/prbm.s14243. PMC 3218785. PMID 22114542.
^ Hollinger MA (19 October 2007). Introduction to Pharmacology (Third ed.). Abingdon: CRC Press. pp. 222–223. ISBN 978-1-4200-4742-4.
^ "The Medicines (Products Other Than Veterinary Drugs) (General Sale List) Amendment Order 2001". legislation.gov.uk. Retrieved 2 August 2022.
^ Nicotine. United States National Library of Medicine – National Center for Biotechnology Information. 16 February 2019. Retrieved 12 May 2024. {{cite encyclopedia}}: |work= ignored (help)
^ Landoni JH. "Nicotine (PIM)". INCHEM. International Programme on Chemical Safety. Retrieved 29 January 2019.

[Dependence-withdrawal-1] Cite error: The named reference Dependence-withdrawal was invoked but never defined (see the help page).

[2] Cosci F, Pistelli F, Lazzarini N, Carrozzi L (2011). "Nicotine dependence and psychological distress: outcomes and clinical implications in smoking cessation". Psychology Research and Behavior Management. 4: 119–28. doi:10.2147/prbm.s14243. PMC 3218785. PMID 22114542.

[3] Hollinger MA (19 October 2007). Introduction to Pharmacology (Third ed.). Abingdon: CRC Press. pp. 222–223. ISBN 978-1-4200-4742-4.

[4] "The Medicines (Products Other Than Veterinary Drugs) (General Sale List) Amendment Order 2001". legislation.gov.uk. Retrieved 2 August 2022.

[PubChem_Nicotine-5] Nicotine. United States National Library of Medicine – National Center for Biotechnology Information. 16 February 2019. Retrieved 12 May 2024. {{cite encyclopedia}}: |work= ignored (help)

[inchem-6] Landoni JH. "Nicotine (PIM)". INCHEM. International Programme on Chemical Safety. Retrieved 29 January 2019.

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