From Wikipedia, the free encyclopedia
Albumin I (PA1b) is a hormone-like peptide found in the seeds of legumes such as the pea plant (Pisum sativum )[2] or soya bean (Glycine max )[3] which have been shown to have insecticidal properties.[2]
It stimulates kinase activity upon binding a membrane bound 43 kDa receptor within the plant which affects cell proliferation.[3]
The structure reveals an inhibitor cystine knot (knottin)-like fold, comprising three beta strands .[1] [2]
References [ edit ]
^ a b Jouvensal, L.; Quillien, L.; Ferrasson, E.; Rahbé, Y.; Guéguen, J.; Vovelle, F. O. (2003). "PA1b, an Insecticidal Protein Extracted from Pea Seeds (Pisum sativum): 1H-2-D NMR Study and Molecular Modeling†,‡". Biochemistry . 42 (41): 11915–11923. doi :10.1021/bi034803l . PMID 14556622 .
^ a b c Da Silva, P.; Rahioui, I.; Laugier, C.; Jouvensal, L.; Meudal, H.; Chouabe, C.; Delmas, A. F.; Gressent, F. (2010). "Molecular Requirements for the Insecticidal Activity of the Plant Peptide Pea Albumin 1 Subunit b (PA1b)" . Journal of Biological Chemistry . 285 (43): 32689–32694. doi :10.1074/jbc.M110.147199 . PMC 2963353 . PMID 20660598 .
^ a b Yamazaki T, Takaoka M, Katoh E, Hanada K, Sakita M, Sakata K, Nishiuchi Y, Hirano H (March 2003). "A possible physiological function and the tertiary structure of a 4-kDa peptide in legumes" . Eur. J. Biochem . 270 (6): 1269–76. doi :10.1046/j.1432-1033.2003.03489.x . PMID 12631285 .