User talk:Zacmea

Welcome[edit]

Welcome...

Hello, Zacmea, and welcome to Wikipedia! Thank you for your contributions. I hope you like the place and decide to stay. Here are some pages that you might find helpful:

Please sign your name on talk pages using four tildes (~~~~); this will automatically produce your username and the date. If you need help, check out Wikipedia:Questions, ask me on my talk page, or place {{helpme}} on your talk page and ask your question there. Again, welcome! Sophus Bie ^(talk) 09:33, 23 March 2009 (UTC)[reply]

To whomever is hiding behind IP 70.137.137.134, please 1) create a username if you intend to make large changes or communicate with people. Having only an IP address makes it impossible to communicate back with you (which is, sadly, probably what you wanted), and 2)while I don't mean to be as rude to you as you were to me, your own English skills make me doubt how well you can assess the creditability of sources; however, your source is self-contradictory, stating in one breath that alprazolam is unlikely to produce dependance, but that withdrawal symptoms are common. Withdrawal happens only once physical dependance has been established; otherwise it is called a side effect instead. As for contradicting the rest of the article, yes, the Wikipedia article on alprazolam says in the same disputed paragraph that it is the most abused benzodiazepine in the US; yes, it has potential for abuse.

Neither your source nor your own argument stand up to very basic logic, and both contradict statements found elsewhere in the article. As well, you hide behind anonymity. I'm sorry, but I cannot accept that you are correct.

above unsigned by User:Zacmea ---

Please read what I explained to you below. IP edits and discussions are perfectly legitimate in Wikipedia. If the reference calls it like that, then that it is. It is unlikely that you know better than the author of this review article, and you are not yet teaching here. Please learn the basic rules first. Wikipedia articles should refer only to facts and interpretations that have been stated in print or on reputable websites or other forms of media. See above, in the introductory greeting given to you. So your interpretation is immaterial. For medical articles special rules apply, namely WP:MEDRS, please read them. Thank you. All your previous edits have been reverted for similar reasons, you constantly claim to know better than the other editors or the sources. Besides, my English skills are fine. 70.137.146.135 (talk) 18:22, 8 August 2011 (UTC)[reply]

re Alprazolam[edit]

You don't read the references before editing and removing "unsourced statements", do you? Here the text of the reference to which it was correctly cited:

Clinical pharmacology, clinical efficacy, and behavioral toxicity of alprazolam: a review of the literature. Verster JC, Volkerts ER. Source

Utrecht Institute for Pharmaceutical Sciences, Department of Psychopharmacology, University of Utrecht, P. O. Box 80082, 3508 TB, Utrecht, The Netherlands. j.c.verster@pharm.uu.nl. Abstract

Alprazolam is a benzodiazepine derivative that is currently used in the treatment of generalized anxiety, panic attacks with or without agoraphobia, and depression. Alprazolam has a fast onset of symptom relief (within the first week); it is unlikely to produce dependency or abuse. No tolerance to its therapeutic effect has been reported. At discontinuation of alprazolam treatment, withdrawal and rebound symptoms are common. Hence, alprazolam discontinuation must be tapered. An exhaustive review of the literature showed that alprazolam is significantly superior to placebo, and is at least equally effective in the relief of symptoms as tricyclic antidepressants (TCAs), such as imipramine. However, although alprazolam and imipramine are significantly more effective than placebo in the treatment of panic attacks, Selective Serotonin Reuptake Inhibitors (SSRIs) appear to be superior to either of the two drugs. Therefore, alprazolam is recommended as a second line treatment option, when SSRIs are not effective or well tolerated. In addition to its therapeutic effects, alprazolam produces adverse effects, such as drowsiness and sedation. Since alprazolam is widely used, many clinical studies investigated its cognitive and psychomotor effects. It is evident from these studies that alprazolam may impair performance in a variety of skills in healthy volunteers as well as in patients. Since the majority of alprazolam users are outpatients, this behavioral impairment limits the safe use of alprazolam in patients routinely engaged in potentially dangerous daily activities, such as driving a car.

PMID:

   14978513
   [PubMed - indexed for MEDLINE]

So this is by no means contradictory, unsourced and ill placed - it is what this ref says! I have bolded it above for you. In the future please open the ref by clicking on it, then on the PMID number, then you see.

It is not contradictory, as only very few of the people to whom it is prescribed become dependent. That it is the most abused in US is because it is also the most prescribed in the US, 44 millions presciptions per year. It is unlikely to produce dependency or abuse, except in people who become also easily dependent on alcohol. (alcoholics type people). Other people usually dislike the tired feeling it produces, drowsiness and the like. see above ref. A rebound and withdrawal effect, which needs tapering, is not indicative of dependency and abuse, like in addicts. Many blood pressure medications produce that on sudden discontinuation, then the blood pressure shoots up, but nobody is dependent on them or abuses them. I hope this explains it. And please open and read the references before editing. Please, as a teacher you should do this right and above all be able to do this right. How else would you be able to teach. 70.137.137.134 (talk) 02:21, 8 August 2011 (UTC)[reply]

Here the link to pubmed government site for the reference above.

http://www.ncbi.nlm.nih.gov/pubmed/14978513 70.137.137.134 (talk) 01:16, 8 August 2011 (UTC)[reply]

Please read WP:MEDRS, the rules about reliable medical sources. Thank you. 70.137.146.135 (talk) 18:07, 8 August 2011 (UTC)[reply]

For communications about an article, please use the discussion page, preferably do not intersperse your comments, preferably keep the discussion in one piece, such that it is readable, sign your contribution. And please read the guide for sources and medical sources. Wiki is not a platform for your own original thoughts and logic synthesis. Thank you. 70.137.146.135 (talk) 20:03, 8 August 2011 (UTC)[reply]

Your input is needed on the SOPA initiative[edit]

Hi Zacmea,

You are receiving this message either because you expressed an opinion about the proposed SOPA blackout before full blackout and soft blackout were adequately differentiated, or because you expressed general support without specifying a preference. Please ensure that your voice is heard by clarifying your position accordingly.

Thank you.

Message delivered as per request on ANI. -- The Helpful Bot 16:47, 14 January 2012 (UTC) [reply]