User talk:Eda2y

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Welcome![edit]

Hello, Eda2y, and welcome to Wikipedia! My name is Ian and I work with the Wiki Education Foundation; I help support students who are editing as part of a class assignment.

I hope you enjoy editing here. If you haven't already done so, please check out the student training library, which introduces you to editing and Wikipedia's core principles. You may also want to check out the Teahouse, a community of Wikipedia editors dedicated to helping new users. Below are some resources to help you get started editing.

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  • You can find answers to many student questions on our Q&A site, ask.wikiedu.org

If you have any questions, please don't hesitate to contact me on my talk page. Ian (Wiki Ed) (talk) 18:49, 5 September 2018 (UTC)[reply]


Reverting[edit]

Hi. I noticed that you reverted an edit by Boghog on the Twinkle (protein) article. If someone removes your additions to a Wikipedia article, you can't just reinstate your work without first discussing things and figuring out what the problem was. Simply reinstating your edits is considered edit-warring, and is not acceptable. This is something that was covered in the training modules, and was even a question in the quiz you had to answer to finish the module. Ian (Wiki Ed) (talk)

Twinkle[edit]

@Eda2y, Daniel.Knorp, Jmarcellus713, Ks7n, Rma3t-mtsu, and Mona Kanakrieh: You seem to have run into problems with your contributions to the Twinkle (protein) article. I wanted to give you some feedback on some of the specific problems. If you look at the Discovery section:

In 2001, Spelbrink et al. were able to identify the gene C10ORF2 and named it Twinkle when they explored in a region to locate open reading frames, ORFs, that had linkage with PEOA3 (609286) located on 10q24. The discovered gene encodes for a protein that resembles T7 GP4 [1]. The team predicted the full length of the protein to be 684 units of amino acids and a 77 kD of molecular mass [1]. Twinkle has an N-terminus mitochondrial targeting sequence. In comparison, another protein, authors refer to as twinky, is encoded by a variant mRNA that has 582 amino acid polymers with 66 kD of molecular mass. The residues 579 to 684 are absent in the variant and has 4 different amino acids at the terminal side. Authors found that the production of Twinkle was relatively high amounts in cells of skeletal muscles and pancreas, but expressed at low amounts in cardiocytes. The approximate amount of Twinkle production in skeletal muscle was not estimated properly due to the strong cross-reacting alpha-actin mRNA type that is under the beta-actin mRNA [1] [2]. The location of the Twinkle gene is found in the mitochondrial nucleoids and appears with a unique localization pattern that is similar to twinkling stars, hence the name. It was noted that Twinkle is overexpressed in cells that have a relatively increased mtDNA helicase activity [1]. It was also discovered that that function of the gene is critical for the organization and maintenance of human mtDNA fidelity [1].

References

  1. ^ a b c d e Cite error: The named reference pmid11431692 was invoked but never defined (see the help page).
  2. ^ Van Hove, Johan L.K.; Cunningham, Vicki; Rice, Cathlin; Ringel, Steven P.; Zhang, Qing; Chou, Ping-Chieh; Truong, Cavatina K.; Wong, Lee-Jun C. (2009-04-07). "Finding twinkle in the eyes of a 71-year-old lady: A case report and review of the genotypic and phenotypic spectrum of TWINKLE-related dominant disease". American Journal of Medical Genetics Part A. 149A (5): 861–867. doi:10.1002/ajmg.a.32731. ISSN 1552-4825.
  • While this style is appropriate for research papers, this isn't the appropriate style for an encyclopedia article. Start with the most important information first, and follow it up with details. Don't go the chronological route - your readers want to have the story revealed bit by bit. Stick to the facts.
  • Use secondary sources. You shouldn't use Spelbrink et al. as a source to talk about their own work.
  • Use normal English, not jargon - don't say things like "Spelbrink et al. were..." Don't say things like "authors refer to" or "the team predicted".
  • Don't describe the experiment, or the methods, or the details. Something like "Samples were taken from muscle cells and blood." just isn't that important to the article about Twinkle. It's a detail of the experimental design, it's not a major finding. It unlikely that a textbook writing about this protein would include that kind of detail.
  • Make sure that what you're saying is comprehensible to the average person. For example, when you say something like "The residues 579 to 684 are absent in the variant and has 4 different amino acids at the terminal side" many of your readers aren't going to understand what you're talking about, or understand its significance.
  • Don't use passive voice. Don't say "It was noted that Twinkle is overexpressed..." People note things, they don't note themselves.
  • Make sure that there's some way for your readers to learn more - link terms that they're likely to be unfamiliar with to other articles that can discuss them in more depth.

Remember that Wikipedia uses a very spare style. Just the facts. Don't elaborate too much. Ian (Wiki Ed) (talk) 17:36, 19 November 2018 (UTC)[reply]

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