Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 18:26, 7 November 2007 (UTC)[edit]
Proteins without matches (16)[edit]
Proteins with a High Potential Match (9)[edit]
Created (8)[edit]
Manual Inspection (Page not found) (17)[edit]
Protein Status Grid - Date: 18:26, 7 November 2007 (UTC)[edit]
Vebose Log - Date: 18:26, 7 November 2007 (UTC)[edit]
- INFO: Beginning work on ADA... {November 7, 2007 2:31:13 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ADA image.jpg {November 7, 2007 2:32:07 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:32:15 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ADA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1krm.
| PDB = {{PDB2|1krm}}, {{PDB2|1ndv}}, {{PDB2|1ndw}}, {{PDB2|1ndy}}, {{PDB2|1ndz}}, {{PDB2|1o5r}}, {{PDB2|1qxl}}, {{PDB2|1uml}}, {{PDB2|1v79}}, {{PDB2|1v7a}}, {{PDB2|1vfl}}, {{PDB2|1w1i}}, {{PDB2|1wxy}}, {{PDB2|1wxz}}, {{PDB2|2bgn}}, {{PDB2|2e1w}}
| Name = Adenosine deaminase
| HGNCid = 186
| Symbol = ADA
| AltSymbols =;
| OMIM = 608958
| ECnumber =
| Homologene = 37249
| MGIid = 87916
| GeneAtlas_image1 = PBB_GE_ADA_204639_at_tn.png
| GeneAtlas_image2 = PBB_GE_ADA_216705_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004000 |text = adenosine deaminase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006163 |text = purine nucleotide metabolic process}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0009168 |text = purine ribonucleoside monophosphate biosynthetic process}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 100
| Hs_Ensembl = ENSG00000196839
| Hs_RefseqProtein = NP_000013
| Hs_RefseqmRNA = NM_000022
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 42681577
| Hs_GenLoc_end = 42713797
| Hs_Uniprot = P00813
| Mm_EntrezGene = 11486
| Mm_Ensembl = ENSMUSG00000017697
| Mm_RefseqmRNA = NM_007398
| Mm_RefseqProtein = NP_031424
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 163418025
| Mm_GenLoc_end = 163441618
| Mm_Uniprot = Q4FJZ7
}}
}}
'''Adenosine deaminase''', also known as '''ADA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Adenosine deaminase catalyzes the hydrolysis of adenosine to inosine. ADA deficiency causes one form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins.<ref>{{cite web | title = Entrez Gene: ADA adenosine deaminase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=100| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=da Cunha JG |title=[Adenosine deaminase. A pluridisciplinary enzyme] |journal=Acta médica portuguesa |volume=4 |issue= 6 |pages= 315-23 |year= 1992 |pmid= 1807098 |doi= }}
*{{cite journal | author=Franco R, Casadó V, Ciruela F, ''et al.'' |title=Cell surface adenosine deaminase: much more than an ectoenzyme. |journal=Prog. Neurobiol. |volume=52 |issue= 4 |pages= 283-94 |year= 1997 |pmid= 9247966 |doi= }}
*{{cite journal | author=Moriwaki Y, Yamamoto T, Higashino K |title=Enzymes involved in purine metabolism--a review of histochemical localization and functional implications. |journal=Histol. Histopathol. |volume=14 |issue= 4 |pages= 1321-40 |year= 1999 |pmid= 10506947 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ANG... {November 7, 2007 2:32:15 AM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:32:28 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:32:42 AM PST}
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{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ANG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a4y.
| PDB = {{PDB2|1a4y}}, {{PDB2|1ang}}, {{PDB2|1awz}}, {{PDB2|1b1e}}, {{PDB2|1b1i}}, {{PDB2|1b1j}}, {{PDB2|1h0d}}, {{PDB2|1h52}}, {{PDB2|1h53}}, {{PDB2|1hby}}, {{PDB2|1k58}}, {{PDB2|1k59}}, {{PDB2|1k5a}}, {{PDB2|1k5b}}, {{PDB2|1un3}}, {{PDB2|1un4}}, {{PDB2|1un5}}, {{PDB2|2ang}}
| Name = Angiogenin, ribonuclease, RNase A family, 5
| HGNCid = 483
| Symbol = ANG
| AltSymbols =; MGC71966; RNASE4; RNASE5
| OMIM = 105850
| ECnumber =
| Homologene = 74385
| MGIid = 88022
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0004522 |text = pancreatic ribonuclease activity}} {{GNF_GO|id=GO:0004540 |text = ribonuclease activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0008201 |text = heparin binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0019843 |text = rRNA binding}}
| Component = {{GNF_GO|id=GO:0005605 |text = basal lamina}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}} {{GNF_GO|id=GO:0032311 |text = angiogenin-PRI complex}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0001541 |text = ovarian follicle development}} {{GNF_GO|id=GO:0001666 |text = response to hypoxia}} {{GNF_GO|id=GO:0001890 |text = placenta development}} {{GNF_GO|id=GO:0001938 |text = positive regulation of endothelial cell proliferation}} {{GNF_GO|id=GO:0006651 |text = diacylglycerol biosynthetic process}} {{GNF_GO|id=GO:0007154 |text = cell communication}} {{GNF_GO|id=GO:0007202 |text = phospholipase C activation}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009303 |text = rRNA transcription}} {{GNF_GO|id=GO:0017148 |text = negative regulation of protein biosynthetic process}} {{GNF_GO|id=GO:0030041 |text = actin filament polymerization}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0032431 |text = activation of phospholipase A2}} {{GNF_GO|id=GO:0042592 |text = homeostatic process}} {{GNF_GO|id=GO:0048662 |text = negative regulation of smooth muscle cell proliferation}} {{GNF_GO|id=GO:0050714 |text = positive regulation of protein secretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 283
| Hs_Ensembl =
| Hs_RefseqProtein = NP_001136
| Hs_RefseqmRNA = NM_001145
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 11727
| Mm_Ensembl = ENSMUSG00000072115
| Mm_RefseqmRNA = NM_007447
| Mm_RefseqProtein = NP_031473
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 50018364
| Mm_GenLoc_end = 50023962
| Mm_Uniprot = Q3TBG7
}}
}}
'''Angiogenin, ribonuclease, RNase A family, 5''', also known as '''ANG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.<ref>{{cite web | title = Entrez Gene: ANG angiogenin, ribonuclease, RNase A family, 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=283| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ANXA1... {November 7, 2007 2:32:42 AM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:33:22 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:33:33 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ANXA1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ain.
| PDB = {{PDB2|1ain}}, {{PDB2|1bo9}}
| Name = Annexin A1
| HGNCid = 533
| Symbol = ANXA1
| AltSymbols =; ANX1; LPC1
| OMIM = 151690
| ECnumber =
| Homologene = 563
| MGIid = 96819
| GeneAtlas_image1 = PBB_GE_ANXA1_201012_at_tn.png
| Function = {{GNF_GO|id=GO:0004859 |text = phospholipase inhibitor activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005544 |text = calcium-dependent phospholipid binding}} {{GNF_GO|id=GO:0019834 |text = phospholipase A2 inhibitor activity}} {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}}
| Component = {{GNF_GO|id=GO:0001533 |text = cornified envelope}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0042383 |text = sarcolemma}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0018149 |text = peptide cross-linking}} {{GNF_GO|id=GO:0030216 |text = keratinocyte differentiation}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}} {{GNF_GO|id=GO:0050482 |text = arachidonic acid secretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 301
| Hs_Ensembl = ENSG00000135046
| Hs_RefseqProtein = NP_000691
| Hs_RefseqmRNA = NM_000700
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 74956493
| Hs_GenLoc_end = 74975129
| Hs_Uniprot = P04083
| Mm_EntrezGene = 16952
| Mm_Ensembl = ENSMUSG00000024659
| Mm_RefseqmRNA = NM_010730
| Mm_RefseqProtein = NP_034860
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 20440453
| Mm_GenLoc_end = 20457696
| Mm_Uniprot = Q3U5N9
}}
}}
'''Annexin A1''', also known as '''ANXA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.<ref>{{cite web | title = Entrez Gene: ANXA1 annexin A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=301| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Crompton MR, Moss SE, Crumpton MJ |title=Diversity in the lipocortin/calpactin family. |journal=Cell |volume=55 |issue= 1 |pages= 1-3 |year= 1988 |pmid= 2971450 |doi= }}
*{{cite journal | author=Lim LH, Pervaiz S |title=Annexin 1: the new face of an old molecule. |journal=FASEB J. |volume=21 |issue= 4 |pages= 968-75 |year= 2007 |pmid= 17215481 |doi= 10.1096/fj.06-7464rev }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AURKB... {November 7, 2007 10:17:15 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 10:18:01 AM PST}
- CREATED: Created new protein page: AURKB {November 7, 2007 10:18:10 AM PST}
- INFO: Beginning work on CASP6... {November 7, 2007 2:33:33 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:34:20 AM PST}
- CREATED: Created new protein page: CASP6 {November 7, 2007 2:34:27 AM PST}
- INFO: Beginning work on CD2... {November 7, 2007 2:34:27 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CD2 image.jpg {November 7, 2007 2:34:58 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:35:10 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cdb.
| PDB = {{PDB2|1cdb}}, {{PDB2|1gya}}, {{PDB2|1hnf}}, {{PDB2|1qa9}}
| Name = CD2 molecule
| HGNCid = 1639
| Symbol = CD2
| AltSymbols =; SRBC; T11
| OMIM = 186990
| ECnumber =
| Homologene = 1338
| MGIid = 88320
| GeneAtlas_image1 = PBB_GE_CD2_205831_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001766 |text = lipid raft polarization}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0016337 |text = cell-cell adhesion}} {{GNF_GO|id=GO:0030101 |text = natural killer cell activation}} {{GNF_GO|id=GO:0030887 |text = positive regulation of myeloid dendritic cell activation}} {{GNF_GO|id=GO:0042110 |text = T cell activation}} {{GNF_GO|id=GO:0045580 |text = regulation of T cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 914
| Hs_Ensembl = ENSG00000116824
| Hs_RefseqProtein = NP_001758
| Hs_RefseqmRNA = NM_001767
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 117098530
| Hs_GenLoc_end = 117113373
| Hs_Uniprot = P06729
| Mm_EntrezGene = 12481
| Mm_Ensembl = ENSMUSG00000027863
| Mm_RefseqmRNA = NM_013486
| Mm_RefseqProtein = NP_038514
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 101404969
| Mm_GenLoc_end = 101417000
| Mm_Uniprot = Q5SRC1
}}
}}
'''CD2 molecule''', also known as '''CD2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sayre PH, Reinherz EL |title=Structure and function of the erythrocyte receptor CD2 on human T lymphocytes: a review. |journal=Scand. J. Rheumatol. Suppl. |volume=76 |issue= |pages= 131-44 |year= 1989 |pmid= 2471997 |doi= }}
*{{cite journal | author=Rouleau M, Mollereau B, Bernard A, ''et al.'' |title=CD2 induced apoptosis of peripheral T cells. |journal=Transplant. Proc. |volume=29 |issue= 5 |pages= 2377-8 |year= 1997 |pmid= 9270771 |doi= }}
*{{cite journal | author=Lüscher B |title=Function and regulation of the transcription factors of the Myc/Max/Mad network. |journal=Gene |volume=277 |issue= 1-2 |pages= 1-14 |year= 2001 |pmid= 11602341 |doi= }}
*{{cite journal | author=Yang JJ, Ye Y, Carroll A, ''et al.'' |title=Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. |journal=Curr. Protein Pept. Sci. |volume=2 |issue= 1 |pages= 1-17 |year= 2002 |pmid= 12369898 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CDX2... {November 7, 2007 2:35:10 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:35:47 AM PST}
- CREATED: Created new protein page: CDX2 {November 7, 2007 2:35:54 AM PST}
- INFO: Beginning work on CPB2... {November 7, 2007 2:35:54 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 9:59:01 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Carboxypeptidase B2 (plasma)
| HGNCid = 2300
| Symbol = CPB2
| AltSymbols =; PCPB; CPU; TAFI
| OMIM = 603101
| ECnumber =
| Homologene = 55610
| MGIid = 1891837
| GeneAtlas_image1 = PBB_GE_CPB2_206651_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004182 |text = carboxypeptidase A activity}} {{GNF_GO|id=GO:0004184 |text = lysine carboxypeptidase activity}} {{GNF_GO|id=GO:0008237 |text = metallopeptidase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1361
| Hs_Ensembl = ENSG00000080618
| Hs_RefseqProtein = NP_001863
| Hs_RefseqmRNA = NM_001872
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 45525323
| Hs_GenLoc_end = 45577169
| Hs_Uniprot = Q96IY4
| Mm_EntrezGene = 56373
| Mm_Ensembl = ENSMUSG00000021999
| Mm_RefseqmRNA = NM_019775
| Mm_RefseqProtein = NP_062749
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 73976442
| Mm_GenLoc_end = 74017703
| Mm_Uniprot = Q9JHH6
}}
}}
'''Carboxypeptidase B2 (plasma)''', also known as '''CPB2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Available sequence data analyses indicate splice variants that encode different isoforms.<ref>{{cite web | title = Entrez Gene: CPB2 carboxypeptidase B2 (plasma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1361| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bouma BN, Mosnier LO |title=Thrombin activatable fibrinolysis inhibitor (TAFI) at the interface between coagulation and fibrinolysis. |journal=Pathophysiol. Haemost. Thromb. |volume=33 |issue= 5-6 |pages= 375-81 |year= 2005 |pmid= 15692247 |doi= 10.1159/000083832 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CSF3... {November 7, 2007 9:59:01 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CSF3 image.jpg {November 7, 2007 9:59:41 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 10:00:00 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CSF3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cd9.
| PDB = {{PDB2|1cd9}}, {{PDB2|1gnc}}, {{PDB2|1pgr}}, {{PDB2|1rhg}}, {{PDB2|2d9q}}
| Name = Colony stimulating factor 3 (granulocyte)
| HGNCid = 2438
| Symbol = CSF3
| AltSymbols =; G-CSF; GCSF; MGC45931
| OMIM = 138970
| ECnumber =
| Homologene = 7677
| MGIid = 1339751
| GeneAtlas_image1 = PBB_GE_CSF3_207442_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005130 |text = granulocyte colony-stimulating factor receptor binding}} {{GNF_GO|id=GO:0005138 |text = interleukin-6 receptor binding}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006953 |text = acute-phase response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}} {{GNF_GO|id=GO:0030851 |text = granulocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1440
| Hs_Ensembl = ENSG00000108342
| Hs_RefseqProtein = NP_000750
| Hs_RefseqmRNA = NM_000759
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 35425214
| Hs_GenLoc_end = 35427592
| Hs_Uniprot = P09919
| Mm_EntrezGene = 12985
| Mm_Ensembl = ENSMUSG00000038067
| Mm_RefseqmRNA = NM_009971
| Mm_RefseqProtein = NP_034101
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 98517403
| Mm_GenLoc_end = 98519719
| Mm_Uniprot = Q0VB73
}}
}}
'''Colony stimulating factor 3 (granulocyte)''', also known as '''CSF3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Three transcript variants encoding three different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: CSF3 colony stimulating factor 3 (granulocyte)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1440| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Duarte RF, Franf DA |title=The synergy between stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF): molecular basis and clinical relevance. |journal=Leuk. Lymphoma |volume=43 |issue= 6 |pages= 1179-87 |year= 2003 |pmid= 12152985 |doi= }}
*{{cite journal | author=Mroczko B, Szmitkowski M |title=Hematopoietic cytokines as tumor markers. |journal=Clin. Chem. Lab. Med. |volume=42 |issue= 12 |pages= 1347-54 |year= 2005 |pmid= 15576295 |doi= 10.1515/CCLM.2004.253 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CTBP1... {November 7, 2007 10:00:00 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CTBP1 image.jpg {November 7, 2007 10:01:14 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 10:01:27 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CTBP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hku.
| PDB = {{PDB2|1hku}}, {{PDB2|1hl3}}, {{PDB2|1mx3}}, {{PDB2|2hu2}}
| Name = C-terminal binding protein 1
| HGNCid = 2494
| Symbol = CTBP1
| AltSymbols =; BARS; MGC104684
| OMIM = 602618
| ECnumber =
| Homologene = 1015
| MGIid = 1201685
| GeneAtlas_image1 = PBB_GE_CTBP1_203392_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CTBP1_212863_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CTBP1_213980_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0016616 |text = oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor}} {{GNF_GO|id=GO:0051287 |text = NAD binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006564 |text = L-serine biosynthetic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0019079 |text = viral genome replication}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1487
| Hs_Ensembl = ENSG00000159692
| Hs_RefseqProtein = NP_001012632
| Hs_RefseqmRNA = NM_001012614
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 1195228
| Hs_GenLoc_end = 1232925
| Hs_Uniprot = Q13363
| Mm_EntrezGene = 13016
| Mm_Ensembl = ENSMUSG00000037373
| Mm_RefseqmRNA = XM_990134
| Mm_RefseqProtein = XP_995228
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 33564581
| Mm_GenLoc_end = 33591839
| Mm_Uniprot = Q3TAT1
}}
}}
'''C-terminal binding protein 1''', also known as '''CTBP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.<ref>{{cite web | title = Entrez Gene: CTBP1 C-terminal binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1487| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Chinnadurai G |title=CtBP, an unconventional transcriptional corepressor in development and oncogenesis. |journal=Mol. Cell |volume=9 |issue= 2 |pages= 213-24 |year= 2002 |pmid= 11864595 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CYP2A6... {November 7, 2007 10:01:27 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CYP2A6 image.jpg {November 7, 2007 10:01:41 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 10:02:06 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CYP2A6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1z10.
| PDB = {{PDB2|1z10}}, {{PDB2|1z11}}, {{PDB2|2fdu}}, {{PDB2|2fdv}}, {{PDB2|2fdw}}, {{PDB2|2fdy}}, {{PDB2|2p85}}
| Name = Cytochrome P450, family 2, subfamily A, polypeptide 6
| HGNCid = 2610
| Symbol = CYP2A6
| AltSymbols =; CYP2A; P450C2A; P450PB; CPA6; CYP2A3; CPA7; CPAD; CYPIIA7; P450-IIA4
| OMIM = 122720
| ECnumber =
| Homologene = 86656
| MGIid =
| Function = {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0008389 |text = coumarin 7-hydroxylase activity}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050381 |text = unspecific monooxygenase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1548
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000753
| Hs_RefseqmRNA = NM_000762
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Cytochrome P450, family 2, subfamily A, polypeptide 6''', also known as '''CYP2A6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.<ref>{{cite web | title = Entrez Gene: CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1548| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Fernandez-Salguero P, Gonzalez FJ |title=The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis. |journal=Pharmacogenetics |volume=5 Spec No |issue= |pages= S123-8 |year= 1995 |pmid= 7581481 |doi= }}
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=Pelkonen O, Rautio A, Raunio H, Pasanen M |title=CYP2A6: a human coumarin 7-hydroxylase. |journal=Toxicology |volume=144 |issue= 1-3 |pages= 139-47 |year= 2000 |pmid= 10781881 |doi= }}
*{{cite journal | author=Tyndale RF, Sellers EM |title=Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior. |journal=Therapeutic drug monitoring |volume=24 |issue= 1 |pages= 163-71 |year= 2002 |pmid= 11805739 |doi= }}
*{{cite journal | author=Xu C, Goodz S, Sellers EM, Tyndale RF |title=CYP2A6 genetic variation and potential consequences. |journal=Adv. Drug Deliv. Rev. |volume=54 |issue= 10 |pages= 1245-56 |year= 2003 |pmid= 12406643 |doi= }}
*{{cite journal | author=Kamataki T, Fujieda M, Kiyotani K, ''et al.'' |title=Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk. |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 1 |pages= 306-10 |year= 2005 |pmid= 16176798 |doi= 10.1016/j.bbrc.2005.08.268 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ELAVL1... {November 7, 2007 10:03:04 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 10:03:58 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
| HGNCid = 3312
| Symbol = ELAVL1
| AltSymbols =; ELAV1; HUR; Hua; MelG
| OMIM = 603466
| ECnumber =
| Homologene = 20367
| MGIid = 1100851
| GeneAtlas_image1 = PBB_GE_ELAVL1_201726_at_tn.png
| GeneAtlas_image2 = PBB_GE_ELAVL1_201727_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003730 |text = mRNA 3'-UTR binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006401 |text = RNA catabolic process}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0048255 |text = mRNA stabilization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1994
| Hs_Ensembl = ENSG00000066044
| Hs_RefseqProtein = NP_001410
| Hs_RefseqmRNA = NM_001419
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 7933159
| Hs_GenLoc_end = 8415925
| Hs_Uniprot = Q15717
| Mm_EntrezGene = 15568
| Mm_Ensembl = ENSMUSG00000040028
| Mm_RefseqmRNA = NM_010485
| Mm_RefseqProtein = NP_034615
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 4288343
| Mm_GenLoc_end = 4325086
| Mm_Uniprot = Q3TT05
}}
}}
'''ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)''', also known as '''ELAVL1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It destabilizes mRNAs and thereby regulates gene expression.<ref>{{cite web | title = Entrez Gene: ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1994| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Abdelmohsen K, Lal A, Kim HH, Gorospe M |title=Posttranscriptional orchestration of an anti-apoptotic program by HuR. |journal=Cell Cycle |volume=6 |issue= 11 |pages= 1288-92 |year= 2007 |pmid= 17534146 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FGFR4... {November 7, 2007 10:03:58 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 10:04:57 AM PST}
- CREATED: Created new protein page: FGFR4 {November 7, 2007 10:05:05 AM PST}
- INFO: Beginning work on FKBP1A... {November 7, 2007 10:05:05 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein FKBP1A image.jpg {November 7, 2007 10:06:38 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 10:07:02 AM PST}
- CREATED: Created new protein page: FKBP1A {November 7, 2007 10:07:09 AM PST}
- INFO: Beginning work on HBE1... {November 7, 2007 10:07:09 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HBE1 image.jpg {November 7, 2007 10:07:24 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 10:07:35 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HBE1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a9w.
| PDB = {{PDB2|1a9w}}
| Name = Hemoglobin, epsilon 1
| HGNCid = 4830
| Symbol = HBE1
| AltSymbols =; HBE
| OMIM = 142100
| ECnumber =
| Homologene = 74550
| MGIid = 96027
| Function = {{GNF_GO|id=GO:0005344 |text = oxygen transporter activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005833 |text = hemoglobin complex}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0015671 |text = oxygen transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3046
| Hs_Ensembl =
| Hs_RefseqProtein = NP_005321
| Hs_RefseqmRNA = NM_005330
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 15135
| Mm_Ensembl = ENSMUSG00000052187
| Mm_RefseqmRNA = XM_973830
| Mm_RefseqProtein = XP_978924
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 103725575
| Mm_GenLoc_end = 103727028
| Mm_Uniprot = Q9CR49
}}
}}
'''Hemoglobin, epsilon 1''', also known as '''HBE1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3'<ref>{{cite web | title = Entrez Gene: HBE1 hemoglobin, epsilon 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3046| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Higgs DR, Vickers MA, Wilkie AO, ''et al.'' |title=A review of the molecular genetics of the human alpha-globin gene cluster. |journal=Blood |volume=73 |issue= 5 |pages= 1081-104 |year= 1989 |pmid= 2649166 |doi= }}
*{{cite journal | author=Clegg JB |title=Embryonic hemoglobin: sequence of the epsilon and zeta chains. |journal=Tex. Rep. Biol. Med. |volume=40 |issue= |pages= 23-8 |year= 1982 |pmid= 6172865 |doi= }}
*{{cite journal | author=Giardina B, Messana I, Scatena R, Castagnola M |title=The multiple functions of hemoglobin. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=30 |issue= 3 |pages= 165-96 |year= 1995 |pmid= 7555018 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HNRPK... {November 7, 2007 10:09:00 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HNRPK image.jpg {November 7, 2007 10:09:37 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 10:09:57 AM PST}
- CREATED: Created new protein page: HNRPK {November 7, 2007 10:10:05 AM PST}
- INFO: Beginning work on IGF2R... {November 7, 2007 10:10:05 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein IGF2R image.jpg {November 7, 2007 10:11:00 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 10:11:19 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_IGF2R_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e6f.
| PDB = {{PDB2|1e6f}}, {{PDB2|1gp0}}, {{PDB2|1gp3}}, {{PDB2|1gqb}}, {{PDB2|2cnj}}
| Name = Insulin-like growth factor 2 receptor
| HGNCid = 5467
| Symbol = IGF2R
| AltSymbols =; CD222; CIMPR; M6P-R; MPRI
| OMIM = 147280
| ECnumber =
| Homologene = 676
| MGIid = 96435
| GeneAtlas_image1 = PBB_GE_IGF2R_201393_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_IGF2R_201392_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005010 |text = insulin-like growth factor receptor activity}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005520 |text = insulin-like growth factor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005641 |text = nuclear envelope lumen}} {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030140 |text = trans-Golgi network transport vesicle}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006898 |text = receptor-mediated endocytosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3482
| Hs_Ensembl = ENSG00000197081
| Hs_RefseqProtein = NP_000867
| Hs_RefseqmRNA = NM_000876
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 160310121
| Hs_GenLoc_end = 160447573
| Hs_Uniprot = P11717
| Mm_EntrezGene = 16004
| Mm_Ensembl = ENSMUSG00000023830
| Mm_RefseqmRNA = NM_010515
| Mm_RefseqProtein = NP_034645
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 12525771
| Mm_GenLoc_end = 12613022
| Mm_Uniprot = Q7TMR1
}}
}}
'''Insulin-like growth factor 2 receptor''', also known as '''IGF2R''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. In mice, the homologous gene is expressed only from the maternal chromosome.<ref>{{cite web | title = Entrez Gene: IGF2R insulin-like growth factor 2 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3482| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=O'Dell SD, Day IN |title=Insulin-like growth factor II (IGF-II). |journal=Int. J. Biochem. Cell Biol. |volume=30 |issue= 7 |pages= 767-71 |year= 1998 |pmid= 9722981 |doi= }}
*{{cite journal | author=Hawkes C, Kar S |title=The insulin-like growth factor-II/mannose-6-phosphate receptor: structure, distribution and function in the central nervous system. |journal=Brain Res. Brain Res. Rev. |volume=44 |issue= 2-3 |pages= 117-40 |year= 2004 |pmid= 15003389 |doi= 10.1016/j.brainresrev.2003.11.002 }}
*{{cite journal | author=Scott CD, Firth SM |title=The role of the M6P/IGF-II receptor in cancer: tumor suppression or garbage disposal? |journal=Horm. Metab. Res. |volume=36 |issue= 5 |pages= 261-71 |year= 2005 |pmid= 15156403 |doi= 10.1055/s-2004-814477 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ITPR1... {November 7, 2007 10:11:19 AM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 10:12:35 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 10:12:47 AM PST}
- CREATED: Created new protein page: ITPR1 {November 7, 2007 10:12:54 AM PST}
- INFO: Beginning work on MSN... {November 7, 2007 10:12:54 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MSN image.jpg {November 7, 2007 10:13:26 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 10:13:34 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MSN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e5w.
| PDB = {{PDB2|1e5w}}, {{PDB2|1ef1}}, {{PDB2|1j19}}, {{PDB2|1sgh}}, {{PDB2|2d10}}, {{PDB2|2d11}}, {{PDB2|2d2q}}, {{PDB2|2yvc}}
| Name = Moesin
| HGNCid = 7373
| Symbol = MSN
| AltSymbols =;
| OMIM = 309845
| ECnumber =
| Homologene = 1833
| MGIid = 97167
| GeneAtlas_image1 = PBB_GE_MSN_200600_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0008092 |text = cytoskeletal protein binding}}
| Component = {{GNF_GO|id=GO:0001931 |text = uropod}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}} {{GNF_GO|id=GO:0016324 |text = apical plasma membrane}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4478
| Hs_Ensembl = ENSG00000147065
| Hs_RefseqProtein = NP_002435
| Hs_RefseqmRNA = NM_002444
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 64804236
| Hs_GenLoc_end = 64878517
| Hs_Uniprot = P26038
| Mm_EntrezGene = 17698
| Mm_Ensembl = ENSMUSG00000031207
| Mm_RefseqmRNA = NM_010833
| Mm_RefseqProtein = NP_034963
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 92344584
| Mm_GenLoc_end = 92369353
| Mm_Uniprot = Q05DU4
}}
}}
'''Moesin''', also known as '''MSN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement.<ref>{{cite web | title = Entrez Gene: MSN moesin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4478| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tsukita S, Yonemura S |title=ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction. |journal=Curr. Opin. Cell Biol. |volume=9 |issue= 1 |pages= 70-5 |year= 1997 |pmid= 9013673 |doi= }}
*{{cite journal | author=Vaheri A, Carpén O, Heiska L, ''et al.'' |title=The ezrin protein family: membrane-cytoskeleton interactions and disease associations. |journal=Curr. Opin. Cell Biol. |volume=9 |issue= 5 |pages= 659-66 |year= 1997 |pmid= 9330869 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NR4A1... {November 7, 2007 10:07:35 AM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 10:08:27 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 10:09:00 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR4A1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cit.
| PDB = {{PDB2|1cit}}, {{PDB2|1yje}}, {{PDB2|2gbd}}
| Name = Nuclear receptor subfamily 4, group A, member 1
| HGNCid = 7980
| Symbol = NR4A1
| AltSymbols =; GFRP1; HMR; MGC9485; N10; NAK-1; NGFIB; NP10; NUR77; TR3
| OMIM = 139139
| ECnumber =
| Homologene = 1612
| MGIid = 1352454
| GeneAtlas_image1 = PBB_GE_NR4A1_202340_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_NR4A1_210226_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0004879 |text = ligand-dependent nuclear receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0043154 |text = negative regulation of caspase activity}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3164
| Hs_Ensembl = ENSG00000123358
| Hs_RefseqProtein = NP_002126
| Hs_RefseqmRNA = NM_002135
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 50717766
| Hs_GenLoc_end = 50739552
| Hs_Uniprot = P22736
| Mm_EntrezGene = 15370
| Mm_Ensembl = ENSMUSG00000023034
| Mm_RefseqmRNA = NM_010444
| Mm_RefseqProtein = NP_034574
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 101094887
| Mm_GenLoc_end = 101102826
| Mm_Uniprot = Q545Q1
}}
}}
'''Nuclear receptor subfamily 4, group A, member 1''', also known as '''NR4A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple alternatively spliced variants, encoding the same protein, have been identified.<ref>{{cite web | title = Entrez Gene: NR4A1 nuclear receptor subfamily 4, group A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3164| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Winoto A, Littman DR |title=Nuclear hormone receptors in T lymphocytes. |journal=Cell |volume=109 Suppl |issue= |pages= S57-66 |year= 2002 |pmid= 11983153 |doi= }}
*{{cite journal | author=Engelse MA, Arkenbout EK, Pannekoek H, de Vries CJ |title=Activin and TR3 orphan receptor: two 'atheroprotective' genes as evidenced in dedicated mouse models. |journal=Clin. Exp. Pharmacol. Physiol. |volume=30 |issue= 11 |pages= 894-9 |year= 2004 |pmid= 14678255 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OLR1... {November 7, 2007 10:13:34 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein OLR1 image.jpg {November 7, 2007 10:14:06 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 10:14:20 AM PST}
- CREATED: Created new protein page: OLR1 {November 7, 2007 10:14:27 AM PST}
- INFO: Beginning work on PLA2G2A... {November 7, 2007 10:14:27 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PLA2G2A image.jpg {November 7, 2007 10:15:01 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 10:15:24 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PLA2G2A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ayp.
| PDB = {{PDB2|1ayp}}, {{PDB2|1bbc}}, {{PDB2|1db4}}, {{PDB2|1db5}}, {{PDB2|1dcy}}, {{PDB2|1j1a}}, {{PDB2|1kqu}}, {{PDB2|1kvo}}, {{PDB2|1n28}}, {{PDB2|1n29}}, {{PDB2|1pod}}, {{PDB2|1poe}}
| Name = Phospholipase A2, group IIA (platelets, synovial fluid)
| HGNCid = 9031
| Symbol = PLA2G2A
| AltSymbols =; PLA2; MOM1; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2
| OMIM = 172411
| ECnumber =
| Homologene = 254
| MGIid =
| GeneAtlas_image1 = PBB_GE_PLA2G2A_203649_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0047498 |text = calcium-dependent phospholipase A2 activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006644 |text = phospholipid metabolic process}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5320
| Hs_Ensembl = ENSG00000188257
| Hs_RefseqProtein = NP_000291
| Hs_RefseqmRNA = NM_000300
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 20174518
| Hs_GenLoc_end = 20179496
| Hs_Uniprot = P14555
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Phospholipase A2, group IIA (platelets, synovial fluid)''', also known as '''PLA2G2A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kramer RM, Johansen B, Hession C, Pepinsky RB |title=Structure and properties of a secretable phospholipase A2 from human platelets. |journal=Adv. Exp. Med. Biol. |volume=275 |issue= |pages= 35-53 |year= 1990 |pmid= 2239446 |doi= }}
*{{cite journal | author=Law MH, Cotton RG, Berger GE |title=The role of phospholipases A2 in schizophrenia. |journal=Mol. Psychiatry |volume=11 |issue= 6 |pages= 547-56 |year= 2006 |pmid= 16585943 |doi= 10.1038/sj.mp.4001819 }}
*{{cite journal | author=Carlquist JF, Muhlestein JB, Anderson JL |title=Lipoprotein-associated phospholipase A2: a new biomarker for cardiovascular risk assessment and potential therapeutic target. |journal=Expert Rev. Mol. Diagn. |volume=7 |issue= 5 |pages= 511-7 |year= 2007 |pmid= 17892360 |doi= 10.1586/14737159.7.5.511 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PRSS1... {November 7, 2007 10:15:24 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PRSS1 image.jpg {November 7, 2007 10:15:55 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 10:16:15 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRSS1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1trn.
| PDB = {{PDB2|1trn}}
| Name = Protease, serine, 1 (trypsin 1)
| HGNCid = 9475
| Symbol = PRSS1
| AltSymbols =; MGC120175; MGC149362; TRP1; TRY1; TRY4; TRYP1
| OMIM = 276000
| ECnumber =
| Homologene = 68276
| MGIid = 3687012
| GeneAtlas_image1 = PBB_GE_PRSS1_205869_at_tn.png
| Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0004295 |text = trypsin activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007586 |text = digestion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5644
| Hs_Ensembl = ENSG00000173636
| Hs_RefseqProtein = NP_002760
| Hs_RefseqmRNA = NM_002769
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 142136904
| Hs_GenLoc_end = 142140495
| Hs_Uniprot = P07477
| Mm_EntrezGene = 386551
| Mm_Ensembl = ENSMUSG00000059014
| Mm_RefseqmRNA = NM_001003664
| Mm_RefseqProtein = NP_001003664
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 41344917
| Mm_GenLoc_end = 41430791
| Mm_Uniprot =
}}
}}
'''Protease, serine, 1 (trypsin 1)''', also known as '''PRSS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.<ref>{{cite web | title = Entrez Gene: PRSS1 protease, serine, 1 (trypsin 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5644| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Chen JM, Ferec C |title=Molecular basis of hereditary pancreatitis. |journal=Eur. J. Hum. Genet. |volume=8 |issue= 7 |pages= 473-9 |year= 2000 |pmid= 10909845 |doi= 10.1038/sj.ejhg.5200492 }}
*{{cite journal | author=Chen JM, Ferec C |title=Gene conversion-like missense mutations in the human cationic trypsinogen gene and insights into the molecular evolution of the human trypsinogen family. |journal=Mol. Genet. Metab. |volume=71 |issue= 3 |pages= 463-9 |year= 2000 |pmid= 11073713 |doi= 10.1006/mgme.2000.3086 }}
*{{cite journal | author=Chen JM, Montier T, Férec C |title=Molecular pathology and evolutionary and physiological implications of pancreatitis-associated cationic trypsinogen mutations. |journal=Hum. Genet. |volume=109 |issue= 3 |pages= 245-52 |year= 2001 |pmid= 11702203 |doi= 10.1007/s004390100580 }}
*{{cite journal | author=Howes N, Greenhalf W, Stocken DD, Neoptolemos JP |title=Cationic trypsinogen mutations and pancreatitis. |journal=Clin. Lab. Med. |volume=25 |issue= 1 |pages= 39-59 |year= 2005 |pmid= 15749231 |doi= 10.1016/j.cll.2004.12.004 }}
*{{cite journal | author=Kandula L, Whitcomb DC, Lowe ME |title=Genetic issues in pediatric pancreatitis. |journal=Current gastroenterology reports |volume=8 |issue= 3 |pages= 248-53 |year= 2006 |pmid= 16764792 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PRTN3... {November 7, 2007 10:16:15 AM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 10:16:50 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 10:17:15 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRTN3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fuj.
| PDB = {{PDB2|1fuj}}
| Name = Proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen)
| HGNCid = 9495
| Symbol = PRTN3
| AltSymbols =; ACPA; AGP7; C-ANCA; MBT; P29; PR-3
| OMIM = 177020
| ECnumber =
| Homologene = 20615
| MGIid = 893580
| GeneAtlas_image1 = PBB_GE_PRTN3_207341_at_tn.png
| Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0030574 |text = collagen catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5657
| Hs_Ensembl = ENSG00000196415
| Hs_RefseqProtein = NP_002768
| Hs_RefseqmRNA = NM_002777
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 791985
| Hs_GenLoc_end = 799175
| Hs_Uniprot = P24158
| Mm_EntrezGene = 19152
| Mm_Ensembl = ENSMUSG00000057729
| Mm_RefseqmRNA = NM_011178
| Mm_RefseqProtein = NP_035308
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 79282796
| Mm_GenLoc_end = 79286303
| Mm_Uniprot = Q61096
}}
}}
'''Proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen)''', also known as '''PRTN3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Watorek E, Boratyńska M, Klinger M |title=Wegener's granulomatosis--autoimmunity to neutrophil proteinase 3. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=51 |issue= 3 |pages= 157-67 |year= 2004 |pmid= 12894870 |doi= }}
*{{cite journal | author=van der Helm-van Mil AH, Huizinga TW, de Vries RR, Toes RE |title=Emerging patterns of risk factor make-up enable subclassification of rheumatoid arthritis. |journal=Arthritis Rheum. |volume=56 |issue= 6 |pages= 1728-35 |year= 2007 |pmid= 17534941 |doi= 10.1002/art.22716 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TOR1A... {November 7, 2007 10:02:06 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 10:03:04 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Torsin family 1, member A (torsin A)
| HGNCid = 3098
| Symbol = TOR1A
| AltSymbols =; DQ2; DYT1; torsin A
| OMIM = 605204
| ECnumber =
| Homologene = 37263
| MGIid = 1353568
| GeneAtlas_image1 = PBB_GE_TOR1A_202348_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TOR1A_202349_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008462 |text = endopeptidase Clp activity}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006986 |text = response to unfolded protein}} {{GNF_GO|id=GO:0051085 |text = chaperone cofactor-dependent protein folding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1861
| Hs_Ensembl = ENSG00000136827
| Hs_RefseqProtein = NP_000104
| Hs_RefseqmRNA = NM_000113
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 131615043
| Hs_GenLoc_end = 131626234
| Hs_Uniprot = O14656
| Mm_EntrezGene = 30931
| Mm_Ensembl = ENSMUSG00000026849
| Mm_RefseqmRNA = NM_144884
| Mm_RefseqProtein = NP_659133
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 30782636
| Mm_GenLoc_end = 30789942
| Mm_Uniprot = Q3TV62
}}
}}
'''Torsin family 1, member A (torsin A)''', also known as '''TOR1A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1.<ref>{{cite web | title = Entrez Gene: TOR1A torsin family 1, member A (torsin A)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1861| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ozelius LJ, Hewett JW, Page CE, ''et al.'' |title=The gene (DYT1) for early-onset torsion dystonia encodes a novel protein related to the Clp protease/heat shock family. |journal=Advances in neurology |volume=78 |issue= |pages= 93-105 |year= 1998 |pmid= 9750906 |doi= }}
*{{cite journal | author=Ferrari Toninelli G, Spano P, Memo M |title=TorsinA, microtubules and cell polarity. |journal=Funct. Neurol. |volume=18 |issue= 1 |pages= 7-10 |year= 2003 |pmid= 12760408 |doi= }}
*{{cite journal | author=Rothwell JC, Edwards M, Huang YZ, Bhatia KP |title=Physiological studies in carriers of the DYT1 gene mutation. |journal=Rev. Neurol. (Paris) |volume=159 |issue= 10 Pt 1 |pages= 880-4 |year= 2004 |pmid= 14615676 |doi= }}
}}
{{refend}}
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end log.
