User:Mr. Ibrahem/Vardenafil
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| Clinical data | |
|---|---|
| Trade names | Levitra, Staxyn, Vivanza, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a603035 |
| License data | |
| Pregnancy category |
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| Routes of administration | By mouth |
| Drug class | PDE5 inhibitor[1] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 15% |
| Protein binding | 95% |
| Metabolism | Liver (CYP3A4) |
| Onset of action | ~45 min[1] |
| Elimination half-life | 4–5 hours |
| Excretion | Biliary |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C23H32N6O4S |
| Molar mass | 488.61 g·mol−1 |
| 3D model (JSmol) | |
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| (verify) | |
Vardenafil, sold under the brand name Levitra among others, is a medication used to treat erectile dysfunction.[1] It is taken by mouth.[1] Onset is generally in 30 to 60 minutes.[1] There is no evidence of benefit of one agent, within this family, over another.[2]
Common side effects include headache.[1] Other side effects may include allergic reactions, low blood pressure, QT prolongation, and priapism.[2] A lower dose is recommended in those with moderate liver problems.[2] Use with nitrovasodilators is not recommended.[2] It is a PDE5 inhibitor and works by decreasing the breakdown of cyclic guanosine monophosphate (cGMP).[1]
Vardenafil was approved for medical use in Europe and the United States in 2003.[1][2] It is available as a generic medication.[3] In the United Kingdom it costs about 5 pounds per 10 mg dose.[3] In the United States this amount costs about 17 USD as of 2021.[4]
References[edit]
- ^ a b c d e f g h i j k "Levitra". Archived from the original on 4 March 2021. Retrieved 13 September 2021.
- ^ a b c d e f g "Vardenafil Monograph for Professionals". Drugs.com. Archived from the original on 6 May 2021. Retrieved 13 September 2021.
- ^ a b BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 862. ISBN 978-0-85711-369-6.
{{cite book}}: CS1 maint: date format (link) - ^ "Vardenafil Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 13 May 2021. Retrieved 13 September 2021.