User:Mr. Ibrahem/Topiramate
Clinical data | |
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Trade names | Topamax, Trokendi XR, Qudexy XR, others |
Other names | Topiramic acid |
AHFS/Drugs.com | Monograph |
MedlinePlus | a697012 |
License data |
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Pregnancy category |
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Routes of administration | By mouth |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 80% |
Protein binding | 13–17%; 15–41% |
Metabolism | Liver (20–30%) |
Elimination half-life | 19–25 hours |
Excretion | Urine (70–80%) |
Identifiers | |
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Chemical and physical data | |
Formula | C12H21NO8S |
Molar mass | 339.36 g·mol−1 |
3D model (JSmol) | |
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Topiramate, sold under the brand name Topamax among others, is a medication used to treat epilepsy and prevent migraines.[2] It has also been used in alcohol dependence.[2] For epilepsy this includes treatment for generalized or focal seizures.[3] It is taken by mouth.[2]
Common side effects include tingling, loss of appetite, feeling tired, abdominal pain, hair loss, and trouble concentrating.[2][3] Serious side effects may include suicide, increased ammonia levels resulting in encephalopathy, and kidney stones.[2] Use in pregnancy may result in harm to the baby and use during breastfeeding is not recommended.[4] How it works is unclear.[2]
Topiramate was approved for medical use in the United States in 1996.[2] It is available as a generic medication.[3] A month supply in the United Kingdom costs the NHS about £1.40 per month as of 2019.[3] In the United States, the wholesale cost of this amount is about US$4.00.[5] In 2017, it was the 77th most commonly prescribed medication in the United States, with more than ten million prescriptions.[6][7]
References[edit]
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 7 August 2020. Retrieved 6 September 2020.
- ^ a b c d e f g "Topiramate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 6 March 2019. Retrieved 5 March 2019.
- ^ a b c d British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 328. ISBN 9780857113382.
- ^ "Topiramate Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 29 August 2021. Retrieved 3 March 2019.
- ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
- ^ "Topiramate - Drug Usage Statistics". ClinCalc. 23 December 2019. Archived from the original on 28 February 2020. Retrieved 11 April 2020.