User:Mr. Ibrahem/Tapinarof

Mr. Ibrahem/Tapinarof
Clinical data
Trade names	Vtama
Other names	Benvitimod; GSK-2894512; (E)-3,5-Dihydroxy-4-isopropyl-trans-stilbene; 3,5-Dihydroxy-4-isopropylstilbene
License data	US DailyMed: Tapinarof;
Routes of; administration	Topical
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name 5-[(E)-2-Phenylethen-1-yl]-2-(propan-2-yl)benzene-1,3-diol;
Chemical and physical data
Formula	C17H18O2
Molar mass	254.329 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)c1c(cc(cc1O)/C=C/c2ccccc2)O;
	InChI InChI=1S/C17H18O2/c1-12(2)17-15(18)10-14(11-16(17)19)9-8-13-6-4-3-5-7-13/h3-12,18-19H,1-2H3/b9-8+; Key:ZISJNXNHJRQYJO-CMDGGOBGSA-N;

Tapinarof, also known as benvitimod and sold under the brand name Vtama, is a medication used to treat plaque psoriasis.^[1]^[2] It is applied to the skin.^[1]

Common side effects include folliculitis, itchiness, and contact dermatitis.^[1] It is an aryl hydrocarbon receptor activator.^[1]

Tapinarof was approved for medical use in the United States in 2022.^[1] It is not approved in either Europe or the United Kingdom as of 2022.^[3] In the United States 60 grams of 1% cream costs about 1,400 USD as of 2022.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h "Vtama- tapinarof cream". DailyMed. 23 May 2022. Archived from the original on 3 July 2022. Retrieved 19 June 2022.
^ Stein Gold, Linda; Rubenstein, David S.; Peist, Ken; Jain, Piyush; Tallman, Anna M. (September 2021). "Tapinarof cream 1% once daily and benvitimod 1% twice daily are 2 distinct topical medications". Journal of the American Academy of Dermatology. 85 (3): e201–e202. doi:10.1016/j.jaad.2021.04.103.
^ "Tapinarof". SPS - Specialist Pharmacy Service. 29 August 2020. Archived from the original on 26 January 2022. Retrieved 12 December 2022.
^ "Vtama Prices, Coupons, Copay & Patient Assistance". Drugs.com. Retrieved 12 December 2022.

[PI2022-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Vtama- tapinarof cream". DailyMed. 23 May 2022. Archived from the original on 3 July 2022. Retrieved 19 June 2022.

[2] Stein Gold, Linda; Rubenstein, David S.; Peist, Ken; Jain, Piyush; Tallman, Anna M. (September 2021). "Tapinarof cream 1% once daily and benvitimod 1% twice daily are 2 distinct topical medications". Journal of the American Academy of Dermatology. 85 (3): e201–e202. doi:10.1016/j.jaad.2021.04.103.

[SPS2022-3] "Tapinarof". SPS - Specialist Pharmacy Service. 29 August 2020. Archived from the original on 26 January 2022. Retrieved 12 December 2022.

[4] "Vtama Prices, Coupons, Copay & Patient Assistance". Drugs.com. Retrieved 12 December 2022.

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